Association between sleep duration and antibody acquisition after mRNA vaccination against SARS-CoV-2
IntroductionSleep enhances the antibody response to vaccination, but the relationship between sleep and mRNA vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is not fully understood.MethodsIn this prospective observational study, we investigated the influence of sleep...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-12-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1242302/full |
| _version_ | 1797397454126055424 |
|---|---|
| author | Muneto Izuhara Muneto Izuhara Kentaro Matsui Kentaro Matsui Takuya Yoshiike Aoi Kawamura Tomohiro Utsumi Tomohiro Utsumi Kentaro Nagao Kentaro Nagao Ayumi Tsuru Ayumi Tsuru Rei Otsuki Shingo Kitamura Kenichi Kuriyama |
| author_facet | Muneto Izuhara Muneto Izuhara Kentaro Matsui Kentaro Matsui Takuya Yoshiike Aoi Kawamura Tomohiro Utsumi Tomohiro Utsumi Kentaro Nagao Kentaro Nagao Ayumi Tsuru Ayumi Tsuru Rei Otsuki Shingo Kitamura Kenichi Kuriyama |
| author_sort | Muneto Izuhara |
| collection | DOAJ |
| description | IntroductionSleep enhances the antibody response to vaccination, but the relationship between sleep and mRNA vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is not fully understood.MethodsIn this prospective observational study, we investigated the influence of sleep habits on immune acquisition induced by mRNA vaccines against SARS-CoV-2 in 48 healthy adults (BNT-162b2, n=34; mRNA-1273, n=14; female, n=30, 62.5%; male, n=18, 37.5%; median age, 39.5 years; interquartile range, 33.0–44.0 years) from June 2021 to January 2022. The study measured sleep duration using actigraphy and sleep diaries, which covered the periods of the initial and booster vaccinations.ResultsMultivariable linear regression analysis showed that actigraphy-measured objective sleep duration 3 and 7 days after the booster vaccination was independently and significantly correlated with higher antibody titers (B=0.003; 95% confidence interval, 0.000–0.005; Beta=0.337; p=0.02), even after controlling for covariates, including age, sex, the type of vaccine, and reactogenicity to the vaccination. Associations between acquired antibody titer and average objective sleep duration before vaccination, and any period of subjective sleep duration measured by sleep diary were negligible.DiscussionLonger objective, but not subjective, sleep duration after booster vaccination enhances antibody response. Hence, encouraging citizens to sleep longer after mRNA vaccination, especially after a booster dose, may increase protection against SARS-CoV-2.Study registrationThis study is registered at the University Hospital Medical Information Network Center (UMIN: https://www.umin.ac.jp) on July 30, 2021, #UMIN000045009. |
| first_indexed | 2024-03-09T01:10:14Z |
| format | Article |
| id | doaj.art-0016e507f8a64fe981362c777632de9b |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-03-09T01:10:14Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-0016e507f8a64fe981362c777632de9b2023-12-11T06:01:07ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-12-011410.3389/fimmu.2023.12423021242302Association between sleep duration and antibody acquisition after mRNA vaccination against SARS-CoV-2Muneto Izuhara0Muneto Izuhara1Kentaro Matsui2Kentaro Matsui3Takuya Yoshiike4Aoi Kawamura5Tomohiro Utsumi6Tomohiro Utsumi7Kentaro Nagao8Kentaro Nagao9Ayumi Tsuru10Ayumi Tsuru11Rei Otsuki12Shingo Kitamura13Kenichi Kuriyama14Department of Sleep-Wake Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, JapanDepartment of Clinical Laboratory, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo, JapanDepartment of Sleep-Wake Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, JapanDepartment of Clinical Laboratory, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo, JapanDepartment of Sleep-Wake Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, JapanDepartment of Sleep-Wake Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, JapanDepartment of Sleep-Wake Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, JapanDepartment of Psychiatry, The Jikei University School of Medicine, Minato-ku, Tokyo, JapanDepartment of Sleep-Wake Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, JapanDepartment of Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo, JapanDepartment of Sleep-Wake Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, JapanDepartment of Clinical Laboratory, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo, JapanDepartment of Psychiatry, Nihon University School of Medicine, Itabashi-ku, Tokyo, JapanDepartment of Sleep-Wake Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, JapanDepartment of Sleep-Wake Disorders, National Institute of Mental Health, National Center of Neurology and Psychiatry, Kodaira, Tokyo, JapanIntroductionSleep enhances the antibody response to vaccination, but the relationship between sleep and mRNA vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is not fully understood.MethodsIn this prospective observational study, we investigated the influence of sleep habits on immune acquisition induced by mRNA vaccines against SARS-CoV-2 in 48 healthy adults (BNT-162b2, n=34; mRNA-1273, n=14; female, n=30, 62.5%; male, n=18, 37.5%; median age, 39.5 years; interquartile range, 33.0–44.0 years) from June 2021 to January 2022. The study measured sleep duration using actigraphy and sleep diaries, which covered the periods of the initial and booster vaccinations.ResultsMultivariable linear regression analysis showed that actigraphy-measured objective sleep duration 3 and 7 days after the booster vaccination was independently and significantly correlated with higher antibody titers (B=0.003; 95% confidence interval, 0.000–0.005; Beta=0.337; p=0.02), even after controlling for covariates, including age, sex, the type of vaccine, and reactogenicity to the vaccination. Associations between acquired antibody titer and average objective sleep duration before vaccination, and any period of subjective sleep duration measured by sleep diary were negligible.DiscussionLonger objective, but not subjective, sleep duration after booster vaccination enhances antibody response. Hence, encouraging citizens to sleep longer after mRNA vaccination, especially after a booster dose, may increase protection against SARS-CoV-2.Study registrationThis study is registered at the University Hospital Medical Information Network Center (UMIN: https://www.umin.ac.jp) on July 30, 2021, #UMIN000045009.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1242302/fullmRNA SARS-CoV-2 vaccinesleep and immunitylonger objective sleep durationantibody titerBNT-162b2mRNA-1273 |
| spellingShingle | Muneto Izuhara Muneto Izuhara Kentaro Matsui Kentaro Matsui Takuya Yoshiike Aoi Kawamura Tomohiro Utsumi Tomohiro Utsumi Kentaro Nagao Kentaro Nagao Ayumi Tsuru Ayumi Tsuru Rei Otsuki Shingo Kitamura Kenichi Kuriyama Association between sleep duration and antibody acquisition after mRNA vaccination against SARS-CoV-2 Frontiers in Immunology mRNA SARS-CoV-2 vaccine sleep and immunity longer objective sleep duration antibody titer BNT-162b2 mRNA-1273 |
| title | Association between sleep duration and antibody acquisition after mRNA vaccination against SARS-CoV-2 |
| title_full | Association between sleep duration and antibody acquisition after mRNA vaccination against SARS-CoV-2 |
| title_fullStr | Association between sleep duration and antibody acquisition after mRNA vaccination against SARS-CoV-2 |
| title_full_unstemmed | Association between sleep duration and antibody acquisition after mRNA vaccination against SARS-CoV-2 |
| title_short | Association between sleep duration and antibody acquisition after mRNA vaccination against SARS-CoV-2 |
| title_sort | association between sleep duration and antibody acquisition after mrna vaccination against sars cov 2 |
| topic | mRNA SARS-CoV-2 vaccine sleep and immunity longer objective sleep duration antibody titer BNT-162b2 mRNA-1273 |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1242302/full |
| work_keys_str_mv | AT munetoizuhara associationbetweensleepdurationandantibodyacquisitionaftermrnavaccinationagainstsarscov2 AT munetoizuhara associationbetweensleepdurationandantibodyacquisitionaftermrnavaccinationagainstsarscov2 AT kentaromatsui associationbetweensleepdurationandantibodyacquisitionaftermrnavaccinationagainstsarscov2 AT kentaromatsui associationbetweensleepdurationandantibodyacquisitionaftermrnavaccinationagainstsarscov2 AT takuyayoshiike associationbetweensleepdurationandantibodyacquisitionaftermrnavaccinationagainstsarscov2 AT aoikawamura associationbetweensleepdurationandantibodyacquisitionaftermrnavaccinationagainstsarscov2 AT tomohiroutsumi associationbetweensleepdurationandantibodyacquisitionaftermrnavaccinationagainstsarscov2 AT tomohiroutsumi associationbetweensleepdurationandantibodyacquisitionaftermrnavaccinationagainstsarscov2 AT kentaronagao associationbetweensleepdurationandantibodyacquisitionaftermrnavaccinationagainstsarscov2 AT kentaronagao associationbetweensleepdurationandantibodyacquisitionaftermrnavaccinationagainstsarscov2 AT ayumitsuru associationbetweensleepdurationandantibodyacquisitionaftermrnavaccinationagainstsarscov2 AT ayumitsuru associationbetweensleepdurationandantibodyacquisitionaftermrnavaccinationagainstsarscov2 AT reiotsuki associationbetweensleepdurationandantibodyacquisitionaftermrnavaccinationagainstsarscov2 AT shingokitamura associationbetweensleepdurationandantibodyacquisitionaftermrnavaccinationagainstsarscov2 AT kenichikuriyama associationbetweensleepdurationandantibodyacquisitionaftermrnavaccinationagainstsarscov2 |