Expression of sodium-iodide symporter in thyroid gland tumors: immunohistochemical study
One of the key moments of radioiodine therapy, and also radioisotope diagnostics of cancers of a thyroid gland is ability of their cells to accumulate iodide. This ability is provided with activity of the specific transporter – sodium-iodide symporter. Our research has shown disorders of sodium-iodi...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy
2009-01-01
|
| Series: | Морфологія |
| Subjects: | |
| Online Access: | http://www.morphology.dp.ua/_pub/MORPHO-2009-03-01/09boozid.pdf |
| Summary: | One of the key moments of radioiodine therapy, and also radioisotope diagnostics of cancers of a thyroid gland is ability of their cells to accumulate iodide. This ability is provided with activity of the specific transporter – sodium-iodide symporter. Our research has shown disorders of sodium-iodide symporter immunoexpression in all tumors of thyroid gland: from overexpression and absence of plasma membrane expression in differentiated carcinomas, up to weak or actually absent in low differentiated cancers and Hurtle-cells tumors. Thus, there is a prospect of application of the sodium-iodide symporter, as the prognostic marker of thyroid cancers. |
|---|---|
| ISSN: | 1997-9665 |