Anticancer and anti-angiogenic activities of mannooligosaccharides extracted from coconut meal on colorectal carcinoma cells in vitro
Colorectal carcinoma (CRC) is one of the most common malignancies, though there are no effective therapeutic regimens at present. This study aimed to investigate the inhibitory effects of mannooligosaccharides extracted from coconut meal (CMOSs) on the proliferation and migration of human colorectal...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Toxicology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750023001488 |
| _version_ | 1827215670180315136 |
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| author | Patthra Pason Chakrit Tachaapaikoon Waralee Suyama Rattiya Waeonukul Rong Shao Molin Wongwattanakul Temduang Limpaiboon Chirapond Chonanant Nipaporn Ngernyuang |
| author_facet | Patthra Pason Chakrit Tachaapaikoon Waralee Suyama Rattiya Waeonukul Rong Shao Molin Wongwattanakul Temduang Limpaiboon Chirapond Chonanant Nipaporn Ngernyuang |
| author_sort | Patthra Pason |
| collection | DOAJ |
| description | Colorectal carcinoma (CRC) is one of the most common malignancies, though there are no effective therapeutic regimens at present. This study aimed to investigate the inhibitory effects of mannooligosaccharides extracted from coconut meal (CMOSs) on the proliferation and migration of human colorectal cancer HCT116 cells in vitro. The results showed that CMOSs exhibited significant inhibitory activity against HCT116 cell proliferation in a concentration-dependent manner with less cytotoxic effects on the Vero normal cells. CMOSs displayed the ability to increase the activation of caspase-8, –9, and –3/7, as well as the generation of reactive oxygen species (ROS). Moreover, CMOSs suppressed HCT116 cell migration in vitro. Interestingly, treatment of human microvascular endothelial cells (HMVECs) with CMOSs resulted in the inhibition of cell proliferation, cell migration, and capillary-like tube formation, suggesting its anti-vascular angiogenesis. In summary, the results of this study indicate that CMOSs could be a valuable therapeutic candidate for CRC treatment. |
| first_indexed | 2024-03-08T16:50:38Z |
| format | Article |
| id | doaj.art-0019e2e1c2164ec8b7bd6754597f83a9 |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2025-03-21T14:50:55Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-0019e2e1c2164ec8b7bd6754597f83a92024-06-21T07:40:55ZengElsevierToxicology Reports2214-75002024-06-01128290Anticancer and anti-angiogenic activities of mannooligosaccharides extracted from coconut meal on colorectal carcinoma cells in vitroPatthra Pason0Chakrit Tachaapaikoon1Waralee Suyama2Rattiya Waeonukul3Rong Shao4Molin Wongwattanakul5Temduang Limpaiboon6Chirapond Chonanant7Nipaporn Ngernyuang8School of Bioresources and Technology, King Mongkut’s University of Technology Thonburi, Bangkok 10150, Thailand; Pilot Plant Development and Training Institute, King Mongkut’s University of Technology Thonburi, Bangkok 10150, ThailandSchool of Bioresources and Technology, King Mongkut’s University of Technology Thonburi, Bangkok 10150, Thailand; Pilot Plant Development and Training Institute, King Mongkut’s University of Technology Thonburi, Bangkok 10150, ThailandSchool of Bioresources and Technology, King Mongkut’s University of Technology Thonburi, Bangkok 10150, Thailand; Pilot Plant Development and Training Institute, King Mongkut’s University of Technology Thonburi, Bangkok 10150, ThailandSchool of Bioresources and Technology, King Mongkut’s University of Technology Thonburi, Bangkok 10150, Thailand; Pilot Plant Development and Training Institute, King Mongkut’s University of Technology Thonburi, Bangkok 10150, ThailandShanghai Key Laboratory for Gallbladder Cancer-Related Gastroenterological Diseases, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200089, ChinaCentre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Science, Khon Kaen University, Khon Kaen 40002, ThailandCentre for Research and Development of Medical Diagnostic Laboratories, Faculty of Associated Medical Science, Khon Kaen University, Khon Kaen 40002, ThailandDepartment of Medical Technology, Faculty of Allied Health Science, Burapha University, Chonburi 20131, ThailandChulabhorn International College of Medicine, Thammasat University, Pathum Thani 12120, Thailand; Corresponding author.Colorectal carcinoma (CRC) is one of the most common malignancies, though there are no effective therapeutic regimens at present. This study aimed to investigate the inhibitory effects of mannooligosaccharides extracted from coconut meal (CMOSs) on the proliferation and migration of human colorectal cancer HCT116 cells in vitro. The results showed that CMOSs exhibited significant inhibitory activity against HCT116 cell proliferation in a concentration-dependent manner with less cytotoxic effects on the Vero normal cells. CMOSs displayed the ability to increase the activation of caspase-8, –9, and –3/7, as well as the generation of reactive oxygen species (ROS). Moreover, CMOSs suppressed HCT116 cell migration in vitro. Interestingly, treatment of human microvascular endothelial cells (HMVECs) with CMOSs resulted in the inhibition of cell proliferation, cell migration, and capillary-like tube formation, suggesting its anti-vascular angiogenesis. In summary, the results of this study indicate that CMOSs could be a valuable therapeutic candidate for CRC treatment.http://www.sciencedirect.com/science/article/pii/S2214750023001488MannooligosaccharidesAnti-cancerAnti-angiogenesis |
| spellingShingle | Patthra Pason Chakrit Tachaapaikoon Waralee Suyama Rattiya Waeonukul Rong Shao Molin Wongwattanakul Temduang Limpaiboon Chirapond Chonanant Nipaporn Ngernyuang Anticancer and anti-angiogenic activities of mannooligosaccharides extracted from coconut meal on colorectal carcinoma cells in vitro Toxicology Reports Mannooligosaccharides Anti-cancer Anti-angiogenesis |
| title | Anticancer and anti-angiogenic activities of mannooligosaccharides extracted from coconut meal on colorectal carcinoma cells in vitro |
| title_full | Anticancer and anti-angiogenic activities of mannooligosaccharides extracted from coconut meal on colorectal carcinoma cells in vitro |
| title_fullStr | Anticancer and anti-angiogenic activities of mannooligosaccharides extracted from coconut meal on colorectal carcinoma cells in vitro |
| title_full_unstemmed | Anticancer and anti-angiogenic activities of mannooligosaccharides extracted from coconut meal on colorectal carcinoma cells in vitro |
| title_short | Anticancer and anti-angiogenic activities of mannooligosaccharides extracted from coconut meal on colorectal carcinoma cells in vitro |
| title_sort | anticancer and anti angiogenic activities of mannooligosaccharides extracted from coconut meal on colorectal carcinoma cells in vitro |
| topic | Mannooligosaccharides Anti-cancer Anti-angiogenesis |
| url | http://www.sciencedirect.com/science/article/pii/S2214750023001488 |
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