Sarcopenia Diagnosis: Reliability of the Ultrasound Assessment of the Tibialis Anterior Muscle as an Alternative Evaluation Tool
Sarcopenia is a skeletal muscle disorder characterized by reduced muscle mass, strength, and performance. Muscle ultrasound can be helpful in assessing muscle mass, quality, and architecture, and thus possibly useful for diagnosing or screening sarcopenia. The objective of this study was to evaluate...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-11-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/11/2158 |
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| author | Massimiliano Leigheb Alessandro de Sire Matteo Colangelo Domenico Zagaria Federico Alberto Grassi Ottavio Rena Patrizio Conte Pierluigi Neri Alessandro Carriero Gian Mauro Sacchetti Fabio Penna Giuseppina Caretti Elisabetta Ferraro |
| author_facet | Massimiliano Leigheb Alessandro de Sire Matteo Colangelo Domenico Zagaria Federico Alberto Grassi Ottavio Rena Patrizio Conte Pierluigi Neri Alessandro Carriero Gian Mauro Sacchetti Fabio Penna Giuseppina Caretti Elisabetta Ferraro |
| author_sort | Massimiliano Leigheb |
| collection | DOAJ |
| description | Sarcopenia is a skeletal muscle disorder characterized by reduced muscle mass, strength, and performance. Muscle ultrasound can be helpful in assessing muscle mass, quality, and architecture, and thus possibly useful for diagnosing or screening sarcopenia. The objective of this study was to evaluate the reliability of ultrasound assessment of tibialis anterior muscle in sarcopenia diagnosis. We included subjects undergoing total or partial hip replacement, comparing measures with a healthy control group. We measured the following parameters: tibialis anterior muscle thickness, echogenicity, architecture, stiffness, skeletal muscle index (SMI), hand grip strength, and sarcopenia related quality of life evaluated through the SarQoL questionnaire. We included 33 participants with a mean age of 54.97 ± 23.91 years. In the study group we found reduced tibialis anterior muscle thickness compared to the healthy control group (19.49 ± 4.92 vs. 28.94 ± 3.63 mm, <i>p</i> < 0.05) with significant correlation with SarQoL values (r = 0.80, <i>p</i> < 0.05), dynamometer hand strength (r = 0.72, <i>p</i> < 0.05) and SMI (r = 0.76, <i>p</i> < 0.05). Moreover, we found reduced stiffness (32.21 ± 12.31 vs. 27.07 ± 8.04 Kpa, <i>p</i> < 0.05). AUC measures of ROC curves were 0.89 predicting reduced muscle strength, and 0.97 predicting reduced SMI for tibialis anterior muscle thickness, while they were 0.73 and 0.85, respectively, for muscle stiffness. Our findings showed that ultrasound assessment of tibialis anterior muscle might be considered a reliable measurement tool to evaluate sarcopenia. |
| first_indexed | 2024-03-10T05:34:01Z |
| format | Article |
| id | doaj.art-001ae096e7824884835b0f699ea67503 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T05:34:01Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-001ae096e7824884835b0f699ea675032023-11-22T23:03:12ZengMDPI AGDiagnostics2075-44182021-11-011111215810.3390/diagnostics11112158Sarcopenia Diagnosis: Reliability of the Ultrasound Assessment of the Tibialis Anterior Muscle as an Alternative Evaluation ToolMassimiliano Leigheb0Alessandro de Sire1Matteo Colangelo2Domenico Zagaria3Federico Alberto Grassi4Ottavio Rena5Patrizio Conte6Pierluigi Neri7Alessandro Carriero8Gian Mauro Sacchetti9Fabio Penna10Giuseppina Caretti11Elisabetta Ferraro12Orthopaedics and Traumatology Unit, “Maggiore della Carità” Hospital, Department of Health Sciences, University of Piemonte Orientale, 28100 Novara, ItalyDepartment of Medical and Surgical Sciences, University of Catanzaro “Magna Graecia”, 88100 Catanzaro, ItalyOrthopaedics and Traumatology Unit, “Maggiore della Carità” Hospital, Department of Health Sciences, University of Piemonte Orientale, 28100 Novara, ItalyRadiology Unit, “Maggiore della Carità” Hospital, Department of Translational Medicine, University of Piemonte Orientale, 28100 Novara, ItalyOrthopaedics and Traumatology Unit, IRCCS Policlinico San Matteo, Department of Clinical-Surgical, Diagnostics and Pediatrics Sciences, University of Pavia, 27100 Pavia, ItalyThoracic Surgery Unit, “Maggiore della Carità” Hospital, Department of Health Sciences, University of Piemonte Orientale, 28100 Novara, ItalyRadiology Unit, “Maggiore della Carità” Hospital, Department of Translational Medicine, University of Piemonte Orientale, 28100 Novara, ItalyRadiology Unit, “Maggiore della Carità” Hospital, Department of Translational Medicine, University of Piemonte Orientale, 28100 Novara, ItalyRadiology Unit, “Maggiore della Carità” Hospital, Department of Translational Medicine, University of Piemonte Orientale, 28100 Novara, ItalyNuclear Medicine Unit, “Maggiore della Carità” Hospital, 28100 Novara, ItalyDepartment of Clinical and Biological Sciences, University of Torino, 10125 Torino, ItalyDepartment of Biosciences, University of Milan, 20133 Milan, ItalyCell and Developmental Biology Unit, Department of Biology, University of Pisa, 56127 Pisa, ItalySarcopenia is a skeletal muscle disorder characterized by reduced muscle mass, strength, and performance. Muscle ultrasound can be helpful in assessing muscle mass, quality, and architecture, and thus possibly useful for diagnosing or screening sarcopenia. The objective of this study was to evaluate the reliability of ultrasound assessment of tibialis anterior muscle in sarcopenia diagnosis. We included subjects undergoing total or partial hip replacement, comparing measures with a healthy control group. We measured the following parameters: tibialis anterior muscle thickness, echogenicity, architecture, stiffness, skeletal muscle index (SMI), hand grip strength, and sarcopenia related quality of life evaluated through the SarQoL questionnaire. We included 33 participants with a mean age of 54.97 ± 23.91 years. In the study group we found reduced tibialis anterior muscle thickness compared to the healthy control group (19.49 ± 4.92 vs. 28.94 ± 3.63 mm, <i>p</i> < 0.05) with significant correlation with SarQoL values (r = 0.80, <i>p</i> < 0.05), dynamometer hand strength (r = 0.72, <i>p</i> < 0.05) and SMI (r = 0.76, <i>p</i> < 0.05). Moreover, we found reduced stiffness (32.21 ± 12.31 vs. 27.07 ± 8.04 Kpa, <i>p</i> < 0.05). AUC measures of ROC curves were 0.89 predicting reduced muscle strength, and 0.97 predicting reduced SMI for tibialis anterior muscle thickness, while they were 0.73 and 0.85, respectively, for muscle stiffness. Our findings showed that ultrasound assessment of tibialis anterior muscle might be considered a reliable measurement tool to evaluate sarcopenia.https://www.mdpi.com/2075-4418/11/11/2158sarcopeniaultrasonographymusclemuscle thicknessmuscle stiffness |
| spellingShingle | Massimiliano Leigheb Alessandro de Sire Matteo Colangelo Domenico Zagaria Federico Alberto Grassi Ottavio Rena Patrizio Conte Pierluigi Neri Alessandro Carriero Gian Mauro Sacchetti Fabio Penna Giuseppina Caretti Elisabetta Ferraro Sarcopenia Diagnosis: Reliability of the Ultrasound Assessment of the Tibialis Anterior Muscle as an Alternative Evaluation Tool Diagnostics sarcopenia ultrasonography muscle muscle thickness muscle stiffness |
| title | Sarcopenia Diagnosis: Reliability of the Ultrasound Assessment of the Tibialis Anterior Muscle as an Alternative Evaluation Tool |
| title_full | Sarcopenia Diagnosis: Reliability of the Ultrasound Assessment of the Tibialis Anterior Muscle as an Alternative Evaluation Tool |
| title_fullStr | Sarcopenia Diagnosis: Reliability of the Ultrasound Assessment of the Tibialis Anterior Muscle as an Alternative Evaluation Tool |
| title_full_unstemmed | Sarcopenia Diagnosis: Reliability of the Ultrasound Assessment of the Tibialis Anterior Muscle as an Alternative Evaluation Tool |
| title_short | Sarcopenia Diagnosis: Reliability of the Ultrasound Assessment of the Tibialis Anterior Muscle as an Alternative Evaluation Tool |
| title_sort | sarcopenia diagnosis reliability of the ultrasound assessment of the tibialis anterior muscle as an alternative evaluation tool |
| topic | sarcopenia ultrasonography muscle muscle thickness muscle stiffness |
| url | https://www.mdpi.com/2075-4418/11/11/2158 |
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