Hypoxia and Macrophages Act in Concert Towards a Beneficial Outcome in Colon Cancer

Hypoxia and Macrophages Act in Concert Towards a Beneficial Outcome in Colon Cancer

In colon cancer, the prognostic value of macrophages is controversial, and it is still unknown how hypoxia modulates macrophage–cancer cell crosstalk. To unravel this, co-cultures of human primary macrophages and colon cancer cells were performed at 20% and 1% O<sub>2</sub>, followed by...

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Bibliographic Details
Main Authors: Flávia Martins, Rosa Oliveira, Bruno Cavadas, Filipe Pinto, Ana Patrícia Cardoso, Flávia Castro, Bárbara Sousa, Marta Laranjeiro Pinto, Ana João Silva, Diogo Adão, José Pedro Loureiro, Nicole Pedro, Rui Manuel Reis, Luísa Pereira, Maria José Oliveira, Angela Margarida Costa
Format: Article
Language:English
Published: MDPI AG 2020-03-01
Series:Cancers
Subjects:
hypoxia
macrophages
colon cancer
tumor microenvironment
immune cell infiltration
prognosis
Online Access:https://www.mdpi.com/2072-6694/12/4/818

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