Sex-specific frontal-striatal connectivity differences among adolescents with externalizing disorders
Background: Sex-specific neurobiological underpinnings of impulsivity in youth with externalizing disorders have not been well studied. The only report of functional connectivity (FC) findings in this area demonstrated sex differences in fronto-subcortical connectivity in youth with attention-defici...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-01-01
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| Series: | NeuroImage: Clinical |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213158221002333 |
| _version_ | 1818462028233179136 |
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| author | Ya Chai José R. Chimelis-Santiago Kristy A. Bixler Matthew Aalsma Meichen Yu Leslie A. Hulvershorn |
| author_facet | Ya Chai José R. Chimelis-Santiago Kristy A. Bixler Matthew Aalsma Meichen Yu Leslie A. Hulvershorn |
| author_sort | Ya Chai |
| collection | DOAJ |
| description | Background: Sex-specific neurobiological underpinnings of impulsivity in youth with externalizing disorders have not been well studied. The only report of functional connectivity (FC) findings in this area demonstrated sex differences in fronto-subcortical connectivity in youth with attention-deficit/hyperactivity disorder (ADHD). Methods: The current study used functional magnetic resonance imaging (fMRI) to examine sex differences in resting-state seed-based FC, self-rated impulsivity, and their interactions in 11-12-year-old boys (n = 43) and girls (n = 43) with externalizing disorders. Generalized linear models controlling for pubertal development were used. Seeds were chosen in the ventral striatum, medial prefrontal cortex, middle frontal gyrus and amygdala. Results: Impulsivity scores were greater in boys than girls (p < 0.05). Boys showed greater positive connectivity within a ventromedial prefrontal-ventral striatal network. In addition, boys demonstrated weaker connectivity than girls within two medial–lateral prefrontal cortical networks. However, only boys showed greater medial–lateral prefrontal connectivity correlated with greater impulsivity. Conclusions: The findings provide evidence supporting sex differences in both ventral striatal-ventromedial prefrontal and medial–lateral prefrontal functional networks in youth with externalizing disorders. These important networks are thought to be implicated in impulse control. Medial-lateral prefrontal connectivity may represent a male-specific biomarker of impulsivity. |
| first_indexed | 2024-12-14T23:55:31Z |
| format | Article |
| id | doaj.art-001da1d5e10748ad81bb91e0a5efcbd9 |
| institution | Directory Open Access Journal |
| issn | 2213-1582 |
| language | English |
| last_indexed | 2024-12-14T23:55:31Z |
| publishDate | 2021-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage: Clinical |
| spelling | doaj.art-001da1d5e10748ad81bb91e0a5efcbd92022-12-21T22:43:08ZengElsevierNeuroImage: Clinical2213-15822021-01-0132102789Sex-specific frontal-striatal connectivity differences among adolescents with externalizing disordersYa Chai0José R. Chimelis-Santiago1Kristy A. Bixler2Matthew Aalsma3Meichen Yu4Leslie A. Hulvershorn5Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USADepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USADepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USADepartment of Pediatrics, Indiana University School of Medicine, Indianapolis, IN, USAIndiana Alzheimer Disease Research Center, Indiana University School of Medicine, Indianapolis, IN, USA; Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN, USA; Indiana University Network Science Institute, Bloomington, IN, USADepartment of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA; Corresponding author at: Adolescent Behavioral Health Research Program, Department of Psychiatry, Indiana University School of Medicine, 410 W. 10th Street, Suite 2000, Indianapolis, IN 46202, USA.Background: Sex-specific neurobiological underpinnings of impulsivity in youth with externalizing disorders have not been well studied. The only report of functional connectivity (FC) findings in this area demonstrated sex differences in fronto-subcortical connectivity in youth with attention-deficit/hyperactivity disorder (ADHD). Methods: The current study used functional magnetic resonance imaging (fMRI) to examine sex differences in resting-state seed-based FC, self-rated impulsivity, and their interactions in 11-12-year-old boys (n = 43) and girls (n = 43) with externalizing disorders. Generalized linear models controlling for pubertal development were used. Seeds were chosen in the ventral striatum, medial prefrontal cortex, middle frontal gyrus and amygdala. Results: Impulsivity scores were greater in boys than girls (p < 0.05). Boys showed greater positive connectivity within a ventromedial prefrontal-ventral striatal network. In addition, boys demonstrated weaker connectivity than girls within two medial–lateral prefrontal cortical networks. However, only boys showed greater medial–lateral prefrontal connectivity correlated with greater impulsivity. Conclusions: The findings provide evidence supporting sex differences in both ventral striatal-ventromedial prefrontal and medial–lateral prefrontal functional networks in youth with externalizing disorders. These important networks are thought to be implicated in impulse control. Medial-lateral prefrontal connectivity may represent a male-specific biomarker of impulsivity.http://www.sciencedirect.com/science/article/pii/S2213158221002333Externalizing disordersImpulsivityAdolescenceSex DifferencesResting-state Functional ConnectivityFrontal-striatal Connectivity |
| spellingShingle | Ya Chai José R. Chimelis-Santiago Kristy A. Bixler Matthew Aalsma Meichen Yu Leslie A. Hulvershorn Sex-specific frontal-striatal connectivity differences among adolescents with externalizing disorders NeuroImage: Clinical Externalizing disorders Impulsivity Adolescence Sex Differences Resting-state Functional Connectivity Frontal-striatal Connectivity |
| title | Sex-specific frontal-striatal connectivity differences among adolescents with externalizing disorders |
| title_full | Sex-specific frontal-striatal connectivity differences among adolescents with externalizing disorders |
| title_fullStr | Sex-specific frontal-striatal connectivity differences among adolescents with externalizing disorders |
| title_full_unstemmed | Sex-specific frontal-striatal connectivity differences among adolescents with externalizing disorders |
| title_short | Sex-specific frontal-striatal connectivity differences among adolescents with externalizing disorders |
| title_sort | sex specific frontal striatal connectivity differences among adolescents with externalizing disorders |
| topic | Externalizing disorders Impulsivity Adolescence Sex Differences Resting-state Functional Connectivity Frontal-striatal Connectivity |
| url | http://www.sciencedirect.com/science/article/pii/S2213158221002333 |
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