Hydroxyapatite and a New Fibrin Sealant Derived from Snake Venom as Scaffold to Treatment of Cranial Defects in Rats
Biomaterials are used as a promising alternative to bone grafts, including bioceramics whose composition resembles that of bone and fibrin sealants due to their hemostatic properties. The objective was to evaluate the repair of cranial defects in 40 rats, grafted with hydroxyapatite and a new fibrin...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol)
2015-02-01
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| Series: | Materials Research |
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| Online Access: | http://www.scielo.br/pdf/mr/v18n1/1516-1439-mr-18-01-00196.pdf |
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| author | Marcelo Rodrigues da Cunha Fernanda Araujo Menezes Geovane Ribeiro dos Santos Clóvis Antônio Lopes Pinto Benedito Barraviera Virginia da Conceição Amaro Martins Ana Maria de Guzzi Plepis Rui Seabra Ferreira Junior |
| author_facet | Marcelo Rodrigues da Cunha Fernanda Araujo Menezes Geovane Ribeiro dos Santos Clóvis Antônio Lopes Pinto Benedito Barraviera Virginia da Conceição Amaro Martins Ana Maria de Guzzi Plepis Rui Seabra Ferreira Junior |
| author_sort | Marcelo Rodrigues da Cunha |
| collection | DOAJ |
| description | Biomaterials are used as a promising alternative to bone grafts, including bioceramics whose composition resembles that of bone and fibrin sealants due to their hemostatic properties. The objective was to evaluate the repair of cranial defects in 40 rats, grafted with hydroxyapatite and a new fibrin sealant derived from snake venom. The animals were divided into four groups: C (control, no graft); Ha (hydroxyapatite); FS (fibrin sealant), and HaFS (hydroxyapatite and fibrin sealant). The animals were euthanized 2 and 6 weeks after surgery and wound area were submitted to analysis. After 2 weeks, immature bone was formed from the borders of the defect and in groups Ha and HaFS, few hydroxyapatite particles were surrounded by new bone. After 6 weeks, the new bone was mature and surrounded several hydroxyapatite particles, without connective tissue interposition and the volume of new bone was higher in HaFS group. The hydroxyapatite in combination with the new fibrin sealant accelerates bone repair. |
| first_indexed | 2024-12-18T02:28:57Z |
| format | Article |
| id | doaj.art-001de8fc061142bcb2dc4152a3666d97 |
| institution | Directory Open Access Journal |
| issn | 1516-1439 |
| language | English |
| last_indexed | 2024-12-18T02:28:57Z |
| publishDate | 2015-02-01 |
| publisher | Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol) |
| record_format | Article |
| series | Materials Research |
| spelling | doaj.art-001de8fc061142bcb2dc4152a3666d972022-12-21T21:23:57ZengAssociação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímeros (ABPol)Materials Research1516-14392015-02-0118119620310.1590/1516-1439.316014Hydroxyapatite and a New Fibrin Sealant Derived from Snake Venom as Scaffold to Treatment of Cranial Defects in RatsMarcelo Rodrigues da CunhaFernanda Araujo MenezesGeovane Ribeiro dos SantosClóvis Antônio Lopes PintoBenedito BarravieraVirginia da Conceição Amaro MartinsAna Maria de Guzzi PlepisRui Seabra Ferreira JuniorBiomaterials are used as a promising alternative to bone grafts, including bioceramics whose composition resembles that of bone and fibrin sealants due to their hemostatic properties. The objective was to evaluate the repair of cranial defects in 40 rats, grafted with hydroxyapatite and a new fibrin sealant derived from snake venom. The animals were divided into four groups: C (control, no graft); Ha (hydroxyapatite); FS (fibrin sealant), and HaFS (hydroxyapatite and fibrin sealant). The animals were euthanized 2 and 6 weeks after surgery and wound area were submitted to analysis. After 2 weeks, immature bone was formed from the borders of the defect and in groups Ha and HaFS, few hydroxyapatite particles were surrounded by new bone. After 6 weeks, the new bone was mature and surrounded several hydroxyapatite particles, without connective tissue interposition and the volume of new bone was higher in HaFS group. The hydroxyapatite in combination with the new fibrin sealant accelerates bone repair.http://www.scielo.br/pdf/mr/v18n1/1516-1439-mr-18-01-00196.pdfbioceramicfibrin sealantbone regeneration |
| spellingShingle | Marcelo Rodrigues da Cunha Fernanda Araujo Menezes Geovane Ribeiro dos Santos Clóvis Antônio Lopes Pinto Benedito Barraviera Virginia da Conceição Amaro Martins Ana Maria de Guzzi Plepis Rui Seabra Ferreira Junior Hydroxyapatite and a New Fibrin Sealant Derived from Snake Venom as Scaffold to Treatment of Cranial Defects in Rats Materials Research bioceramic fibrin sealant bone regeneration |
| title | Hydroxyapatite and a New Fibrin Sealant Derived from Snake Venom as Scaffold to Treatment of Cranial Defects in Rats |
| title_full | Hydroxyapatite and a New Fibrin Sealant Derived from Snake Venom as Scaffold to Treatment of Cranial Defects in Rats |
| title_fullStr | Hydroxyapatite and a New Fibrin Sealant Derived from Snake Venom as Scaffold to Treatment of Cranial Defects in Rats |
| title_full_unstemmed | Hydroxyapatite and a New Fibrin Sealant Derived from Snake Venom as Scaffold to Treatment of Cranial Defects in Rats |
| title_short | Hydroxyapatite and a New Fibrin Sealant Derived from Snake Venom as Scaffold to Treatment of Cranial Defects in Rats |
| title_sort | hydroxyapatite and a new fibrin sealant derived from snake venom as scaffold to treatment of cranial defects in rats |
| topic | bioceramic fibrin sealant bone regeneration |
| url | http://www.scielo.br/pdf/mr/v18n1/1516-1439-mr-18-01-00196.pdf |
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