Oxidative stress promotes fibrosis in systemic sclerosis through stabilization of a kinase-phosphatase complex

Oxidative stress promotes fibrosis in systemic sclerosis through stabilization of a kinase-phosphatase complex

Systemic sclerosis (SSc) is a fibrotic autoimmune disease characterized by pathogenic activation of fibroblasts enhanced by local oxidative stress. The tyrosine phosphatase PTP4A1 was identified as a critical promoter of TGF-β signaling in SSc. Oxidative stress is known to functionally inactivate ty...

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Bibliographic Details
Main Authors: Ruiyuan Zhang, Ganesan Senthil Kumar, Uwe Hansen, Martina Zoccheddu, Cristiano Sacchetti, Zachary J. Holmes, Megan C. Lee, Denise Beckmann, Yutao Wen, Zbigniew Mikulski, Shen Yang, Eugenio Santelli, Rebecca Page, Francesco Boin, Wolfgang Peti, Nunzio Bottini
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-04-01
Series:JCI Insight
Subjects:
Inflammation
Online Access:https://doi.org/10.1172/jci.insight.155761

Internet

https://doi.org/10.1172/jci.insight.155761

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