Oxidative stress promotes fibrosis in systemic sclerosis through stabilization of a kinase-phosphatase complex

Oxidative stress promotes fibrosis in systemic sclerosis through stabilization of a kinase-phosphatase complex

Systemic sclerosis (SSc) is a fibrotic autoimmune disease characterized by pathogenic activation of fibroblasts enhanced by local oxidative stress. The tyrosine phosphatase PTP4A1 was identified as a critical promoter of TGF-β signaling in SSc. Oxidative stress is known to functionally inactivate ty...

Full description

Bibliographic Details
Main Authors:	Ruiyuan Zhang, Ganesan Senthil Kumar, Uwe Hansen, Martina Zoccheddu, Cristiano Sacchetti, Zachary J. Holmes, Megan C. Lee, Denise Beckmann, Yutao Wen, Zbigniew Mikulski, Shen Yang, Eugenio Santelli, Rebecca Page, Francesco Boin, Wolfgang Peti, Nunzio Bottini
Format:	Article
Language:	English
Published:	American Society for Clinical investigation 2022-04-01
Series:	JCI Insight
Subjects:	Inflammation
Online Access:	https://doi.org/10.1172/jci.insight.155761

Similar Items

The mode of action of the Protein tyrosine phosphatase 1B inhibitor Ertiprotafib.
by: Ganesan Senthil Kumar, et al.
Published: (2020-01-01)

The Ki-67 and RepoMan mitotic phosphatases assemble via an identical, yet novel mechanism
by: Ganesan Senthil Kumar, et al.
Published: (2016-08-01)

Interaction of kinase-interaction-motif protein tyrosine phosphatases with the mitogen-activated protein kinase ERK2.
by: Dana M Francis, et al.
Published: (2014-01-01)

Inhibitor-3 inhibits Protein Phosphatase 1 via a metal binding dynamic protein–protein interaction
by: Gautam Srivastava, et al.
Published: (2023-03-01)

Structural and Functional Analysis of the GADD34:PP1 eIF2α Phosphatase
by: Meng S. Choy, et al.
Published: (2015-06-01)

Tomo II: La valutazione come riferimento per la pianificazione: Cagliari e il suo contesto - Il P.O.R.. Percorsi meccanizzati: innovazione nella mobilità urbana
by: Paolo Zoccheddu
Published: (2009-06-01)

Tomo II: La valutazione come riferimento per la pianificazione: Cagliari e il suo contesto - I progetti integrati territoriali. Ricerca delle sinergie pubblico-privato
by: Paolo Zoccheddu
Published: (2009-06-01)

Calcitonin Peptide Family Members Are Differentially Regulated by LPS and Inhibit Functions of Rat Alveolar NR8383 Macrophages.
by: Aichurek Soultanova, et al.
Published: (2016-01-01)

The genetics of feto-placental development: A study of acid phosphatase locus 1 and adenosine deaminase polymorphisms in a consecutive series of newborn infants
by: Bergamaschi Antonio, et al.
Published: (2008-09-01)

Targeting the C-Terminal Domain Small Phosphatase 1
by: Harikrishna Reddy Rallabandi, et al.
Published: (2020-05-01)

Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity
by: Peter Szodoray, et al.
Published: (2021-08-01)

Extreme elevations of alkaline phosphatase in pregnancy: A case report
by: Zachary Stanley, et al.
Published: (2020-07-01)

Redox Regulation of a Gain-of-Function Mutation (N308D) in SHP2 Noonan Syndrome
by: Luciana E. S. F. Machado, et al.
Published: (2017-11-01)

Targeting the Non-catalytic RVxF Site of Protein Phosphatase-1 With Small Molecules for Ebola Virus Inhibition
by: Xionghao Lin, et al.
Published: (2019-09-01)

Protein phosphatases /
by: Arino, Joaquin, et al.
Published: (2004)

Molecular basis of β-lactam antibiotic resistance of ESKAPE bacterium E. faecium Penicillin Binding Protein PBP5
by: Yamanappa Hunashal, et al.
Published: (2023-07-01)

Effect of andrographolide on phosphatases activity and cytotoxicity against Spodoptera litura
by: E Edwin, et al.
Published: (2016-05-01)

Immunomodulatory Microparticles Epigenetically Modulate T Cells and Systemically Ameliorate Autoimmune Arthritis
by: David A. McBride, et al.
Published: (2023-04-01)

Nicotinic receptors on rat alveolar macrophages dampen ATP-induced increase in cytosolic calcium concentration
by: Lohmeyer Jürgen, et al.
Published: (2010-09-01)

The Phosphatase PP2A Interacts With ArnA and ArnB to Regulate the Oligomeric State and the Stability of the ArnA/B Complex
by: Xing Ye, et al.
Published: (2020-08-01)

BdcA, a protein important for Escherichia coli biofilm dispersal, is a short-chain dehydrogenase/reductase that binds specifically to NADPH.
by: Dana M Lord, et al.
Published: (2014-01-01)

Phosphatase Inhibitors Function as Novel, Broad Spectrum Botulinum Neurotoxin Antagonists in Mouse and Human Embryonic Stem Cell-Derived Motor Neuron-Based Assays.
by: Erkan Kiris, et al.
Published: (2015-01-01)

Corrigendum: The Phosphatase PP2A Interacts With ArnA and ArnB to Regulate the Oligomeric State and the Stability of the ArnA/B Complex
by: Xing Ye, et al.
Published: (2020-10-01)

The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1.
by: Eswaran, J, et al.
Published: (2006)

Pan-cancer analyses of classical protein tyrosine phosphatases and phosphatase-targeted therapy in cancer
by: Tao Wang, et al.
Published: (2022-10-01)

Phosphatase activity of Poa pratensis seeds. I. Preliminary studies on acid phosphatase II
by: I. Lorenc-Kubis, et al.
Published: (2015-01-01)

Protein phosphatase 1 β paralogs encode the zebrafish myosin phosphatase catalytic subunit.
by: Vaishali Jayashankar, et al.
Published: (2013-01-01)

Protein phosphatases and the regulation of mitosis.
by: Barr, F, et al.
Published: (2011)

Lipid Phosphate Phosphatases and Cancer
by: Xiaoyun Tang, et al.
Published: (2020-09-01)

CPR: cardiac phosphatase in resuscitation
by: Arjun Deb
Published: (2023-05-01)

Multiple Myeloma and Alkaline Phosphatase
by: İrfan Yavaşoğlu, et al.
Published: (2015-05-01)

Glucose-6-phosphatase deficiency
by: Labrune Philippe, et al.
Published: (2011-05-01)

Lipid phosphate phosphatases and signaling
by: David N. Brindley, et al.
Published: (2009-01-01)

Protein phosphatases in TLR signaling
by: Clovis H. T. Seumen, et al.
Published: (2021-04-01)

Protein Phosphatase 2A Improves Cardiac Functional Response to Ischemia and Sepsis
by: Ulrich Gergs, et al.
Published: (2022-04-01)

Effect of scaling and root planing on salivary alkaline phosphatase and acid phosphatase in patients with chronic periodontitis
by: Chenar Anwar Mohammad, et al.
Published: (2018-01-01)

Regulation of the Human Phosphatase PTPN4 by the inter-domain linker connecting the PDZ and the phosphatase domains
by: Célia Caillet-Saguy, et al.
Published: (2017-08-01)

Acetylcholine content and viability of cholinergic neurons are influenced by the activity of protein histidine phosphatase
by: Eißing Anna, et al.
Published: (2012-03-01)

Ecological Importance of Alkaline Phosphatase Activity and Acid Phosphatase Activity in Lakes with Different Catchment Use Structures
by: Ewelina Janicka, et al.
Published: (2024-01-01)

Phosphoglycolate phosphatase homologs act as glycerol-3-phosphate phosphatase to control stress and healthspan in C. elegans
by: Elite Possik, et al.
Published: (2022-01-01)