Evolutionary origin of vertebrate OCT4/POU5 functions in supporting pluripotency
By constructing an evolutionary trajectory of the cyclostome-gnathostome Pou5 gene family and comparing the structural and phenotypic protein variations, the authors uncover the origin of functional characteristics for the pluripotency factor Oct4.
Bibliographic Details
| Main Authors: |
Woranop Sukparangsi,
Elena Morganti,
Molly Lowndes,
Hélène Mayeur,
Melanie Weisser,
Fella Hammachi,
Hanna Peradziryi,
Fabian Roske,
Jurriaan Hölzenspies,
Alessandra Livigni,
Benoit Gilbert Godard,
Fumiaki Sugahara,
Shigeru Kuratani,
Guillermo Montoya,
Stephen R. Frankenberg,
Sylvie Mazan,
Joshua M. Brickman |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-09-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-32481-z
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