Evolutionary origin of vertebrate OCT4/POU5 functions in supporting pluripotency
By constructing an evolutionary trajectory of the cyclostome-gnathostome Pou5 gene family and comparing the structural and phenotypic protein variations, the authors uncover the origin of functional characteristics for the pluripotency factor Oct4.
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32481-z |
| _version_ | 1811258816705069056 |
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| author | Woranop Sukparangsi Elena Morganti Molly Lowndes Hélène Mayeur Melanie Weisser Fella Hammachi Hanna Peradziryi Fabian Roske Jurriaan Hölzenspies Alessandra Livigni Benoit Gilbert Godard Fumiaki Sugahara Shigeru Kuratani Guillermo Montoya Stephen R. Frankenberg Sylvie Mazan Joshua M. Brickman |
| author_facet | Woranop Sukparangsi Elena Morganti Molly Lowndes Hélène Mayeur Melanie Weisser Fella Hammachi Hanna Peradziryi Fabian Roske Jurriaan Hölzenspies Alessandra Livigni Benoit Gilbert Godard Fumiaki Sugahara Shigeru Kuratani Guillermo Montoya Stephen R. Frankenberg Sylvie Mazan Joshua M. Brickman |
| author_sort | Woranop Sukparangsi |
| collection | DOAJ |
| description | By constructing an evolutionary trajectory of the cyclostome-gnathostome Pou5 gene family and comparing the structural and phenotypic protein variations, the authors uncover the origin of functional characteristics for the pluripotency factor Oct4. |
| first_indexed | 2024-04-12T18:20:18Z |
| format | Article |
| id | doaj.art-0023e003376840899894a0cfbae7cb43 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T18:20:18Z |
| publishDate | 2022-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-0023e003376840899894a0cfbae7cb432022-12-22T03:21:27ZengNature PortfolioNature Communications2041-17232022-09-0113112110.1038/s41467-022-32481-zEvolutionary origin of vertebrate OCT4/POU5 functions in supporting pluripotencyWoranop Sukparangsi0Elena Morganti1Molly Lowndes2Hélène Mayeur3Melanie Weisser4Fella Hammachi5Hanna Peradziryi6Fabian Roske7Jurriaan Hölzenspies8Alessandra Livigni9Benoit Gilbert Godard10Fumiaki Sugahara11Shigeru Kuratani12Guillermo Montoya13Stephen R. Frankenberg14Sylvie Mazan15Joshua M. Brickman16Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), University of CopenhagenNovo Nordisk Foundation Center for Stem Cell Medicine (reNEW), University of CopenhagenNovo Nordisk Foundation Center for Stem Cell Medicine (reNEW), University of CopenhagenCNRS, Sorbonne Université, Biologie Intégrative des Organismes Marins, UMR7232Structural Molecular Biology Group, Novo Nordisk Foundation Center for Protein Research, University of CopenhagenMRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, 5 Little France Drive, University of EdinburghNovo Nordisk Foundation Center for Stem Cell Medicine (reNEW), University of CopenhagenNovo Nordisk Foundation Center for Stem Cell Medicine (reNEW), University of CopenhagenNovo Nordisk Foundation Center for Stem Cell Medicine (reNEW), University of CopenhagenMRC Centre for Regenerative Medicine, Institute for Stem Cell Research, School of Biological Sciences, 5 Little France Drive, University of EdinburghCNRS, Sorbonne Université, UPMC Univ Paris 06, FR2424, Development and Evolution of Vertebrates Group, Station BiologiqueDivision of Biology, Hyogo College of MedicineLaboratory for Evolutionary Morphology, RIKEN Center for Biosystems Dynamics Research (BDR)Structural Molecular Biology Group, Novo Nordisk Foundation Center for Protein Research, University of CopenhagenDepartment of Zoology, University of MelbourneCNRS, Sorbonne Université, Biologie Intégrative des Organismes Marins, UMR7232Novo Nordisk Foundation Center for Stem Cell Medicine (reNEW), University of CopenhagenBy constructing an evolutionary trajectory of the cyclostome-gnathostome Pou5 gene family and comparing the structural and phenotypic protein variations, the authors uncover the origin of functional characteristics for the pluripotency factor Oct4.https://doi.org/10.1038/s41467-022-32481-z |
| spellingShingle | Woranop Sukparangsi Elena Morganti Molly Lowndes Hélène Mayeur Melanie Weisser Fella Hammachi Hanna Peradziryi Fabian Roske Jurriaan Hölzenspies Alessandra Livigni Benoit Gilbert Godard Fumiaki Sugahara Shigeru Kuratani Guillermo Montoya Stephen R. Frankenberg Sylvie Mazan Joshua M. Brickman Evolutionary origin of vertebrate OCT4/POU5 functions in supporting pluripotency Nature Communications |
| title | Evolutionary origin of vertebrate OCT4/POU5 functions in supporting pluripotency |
| title_full | Evolutionary origin of vertebrate OCT4/POU5 functions in supporting pluripotency |
| title_fullStr | Evolutionary origin of vertebrate OCT4/POU5 functions in supporting pluripotency |
| title_full_unstemmed | Evolutionary origin of vertebrate OCT4/POU5 functions in supporting pluripotency |
| title_short | Evolutionary origin of vertebrate OCT4/POU5 functions in supporting pluripotency |
| title_sort | evolutionary origin of vertebrate oct4 pou5 functions in supporting pluripotency |
| url | https://doi.org/10.1038/s41467-022-32481-z |
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