Therapeutic Effect of Dupilumab on Systemic and Vascular Inflammation in Adults with Severe Atopic Dermatitis: Feasibility Study Using 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography
Atopic dermatitis (AD) is an inflammatory skin disease associated with increased systemic and vascular inflammation. Although dupilumab has been proven to be effective against severe AD, imaging studies analysing its inflammation-reducing effect have rarely been reported. The aim of this study was t...
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| Format: | Article |
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Medical Journals Sweden
2023-05-01
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| Series: | Acta Dermato-Venereologica |
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| Online Access: | https://medicaljournalssweden.se/actadv/article/view/5320 |
| _version_ | 1797822304904806400 |
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| author | Gi-Wook Lee Keunyoung Kim Seong-Jang Kim Kihyuk Shin Hoonsoo Kim Hyun-Chang Ko Moon-Bum Kim Byungsoo Kim |
| author_facet | Gi-Wook Lee Keunyoung Kim Seong-Jang Kim Kihyuk Shin Hoonsoo Kim Hyun-Chang Ko Moon-Bum Kim Byungsoo Kim |
| author_sort | Gi-Wook Lee |
| collection | DOAJ |
| description | Atopic dermatitis (AD) is an inflammatory skin disease associated with increased systemic and vascular inflammation. Although dupilumab has been proven to be effective against severe AD, imaging studies analysing its inflammation-reducing effect have rarely been reported. The aim of this study was to evaluate the effect of dupilumab on systemic and vascular inflammation in adult patients with severe AD, using 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT). A total of 33 adult patients with severe AD and 25 healthy controls underwent 18F-FDG PET/CT at baseline. Patients on dupilumab treatment underwent 18F-FDG PET/CT again after achieving a 75% reduction from baseline on the Eczema Area and Severity Index (EASI-75). Patients with AD exhibited increased 18F-FDG uptake values in the liver, spleen, pancreas, and carotid artery compared with healthy controls. However, compared with baseline, there was no statistically significant difference in 18F-FDG uptake in major organs and arteries after achieving EASI-75 with dupilumab treatment. In conclusion, while dupilumab treatment resulted in a significant clinical improvement and reduced serum inflammatory markers in adult patients with severe AD, no changes in systemic and vascular inflammation were observed on 18F-FDG PET/CT imaging.
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| first_indexed | 2024-03-13T10:06:02Z |
| format | Article |
| id | doaj.art-00251b98f2dc4c4580c2fa8bba228356 |
| institution | Directory Open Access Journal |
| issn | 0001-5555 1651-2057 |
| language | English |
| last_indexed | 2024-03-13T10:06:02Z |
| publishDate | 2023-05-01 |
| publisher | Medical Journals Sweden |
| record_format | Article |
| series | Acta Dermato-Venereologica |
| spelling | doaj.art-00251b98f2dc4c4580c2fa8bba2283562023-05-22T12:03:58ZengMedical Journals SwedenActa Dermato-Venereologica0001-55551651-20572023-05-0110310.2340/actadv.v103.5320Therapeutic Effect of Dupilumab on Systemic and Vascular Inflammation in Adults with Severe Atopic Dermatitis: Feasibility Study Using 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed TomographyGi-Wook Lee0Keunyoung Kim1Seong-Jang Kim2Kihyuk Shin3Hoonsoo Kim4Hyun-Chang Ko5Moon-Bum Kim6Byungsoo Kim7Department of Dermatology, School of Medicine, Pusan National University Hospital, Busan, KoreaDepartment of Nuclear Medicine, Pusan National University Hospital, Busan, KoreaDepartment of Nuclear Medicine, Pusan National University Hospital, Busan, KoreaDepartment of Dermatology, School of Medicine, Pusan National University Hospital, Busan, KoreaDepartment of Dermatology, School of Medicine, Pusan National University Hospital, Busan, KoreaDepartment of Dermatology, School of Medicine, Pusan National University Hospital, Busan, KoreaDepartment of Dermatology, School of Medicine, Pusan National University Hospital, Busan, KoreaDepartment of Dermatology, School of Medicine, Pusan National University, Busan, KoreaAtopic dermatitis (AD) is an inflammatory skin disease associated with increased systemic and vascular inflammation. Although dupilumab has been proven to be effective against severe AD, imaging studies analysing its inflammation-reducing effect have rarely been reported. The aim of this study was to evaluate the effect of dupilumab on systemic and vascular inflammation in adult patients with severe AD, using 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET/CT). A total of 33 adult patients with severe AD and 25 healthy controls underwent 18F-FDG PET/CT at baseline. Patients on dupilumab treatment underwent 18F-FDG PET/CT again after achieving a 75% reduction from baseline on the Eczema Area and Severity Index (EASI-75). Patients with AD exhibited increased 18F-FDG uptake values in the liver, spleen, pancreas, and carotid artery compared with healthy controls. However, compared with baseline, there was no statistically significant difference in 18F-FDG uptake in major organs and arteries after achieving EASI-75 with dupilumab treatment. In conclusion, while dupilumab treatment resulted in a significant clinical improvement and reduced serum inflammatory markers in adult patients with severe AD, no changes in systemic and vascular inflammation were observed on 18F-FDG PET/CT imaging. https://medicaljournalssweden.se/actadv/article/view/5320Atopic dermatitisCardiovascular diseaseComorbidityDupilumabInflammationPET/CT: positron emission tomography-computed tomography |
| spellingShingle | Gi-Wook Lee Keunyoung Kim Seong-Jang Kim Kihyuk Shin Hoonsoo Kim Hyun-Chang Ko Moon-Bum Kim Byungsoo Kim Therapeutic Effect of Dupilumab on Systemic and Vascular Inflammation in Adults with Severe Atopic Dermatitis: Feasibility Study Using 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography Acta Dermato-Venereologica Atopic dermatitis Cardiovascular disease Comorbidity Dupilumab Inflammation PET/CT: positron emission tomography-computed tomography |
| title | Therapeutic Effect of Dupilumab on Systemic and Vascular Inflammation in Adults with Severe Atopic Dermatitis: Feasibility Study Using 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography |
| title_full | Therapeutic Effect of Dupilumab on Systemic and Vascular Inflammation in Adults with Severe Atopic Dermatitis: Feasibility Study Using 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography |
| title_fullStr | Therapeutic Effect of Dupilumab on Systemic and Vascular Inflammation in Adults with Severe Atopic Dermatitis: Feasibility Study Using 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography |
| title_full_unstemmed | Therapeutic Effect of Dupilumab on Systemic and Vascular Inflammation in Adults with Severe Atopic Dermatitis: Feasibility Study Using 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography |
| title_short | Therapeutic Effect of Dupilumab on Systemic and Vascular Inflammation in Adults with Severe Atopic Dermatitis: Feasibility Study Using 18F-Fluorodeoxyglucose Positron Emission Tomography-Computed Tomography |
| title_sort | therapeutic effect of dupilumab on systemic and vascular inflammation in adults with severe atopic dermatitis feasibility study using 18f fluorodeoxyglucose positron emission tomography computed tomography |
| topic | Atopic dermatitis Cardiovascular disease Comorbidity Dupilumab Inflammation PET/CT: positron emission tomography-computed tomography |
| url | https://medicaljournalssweden.se/actadv/article/view/5320 |
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