Thoracic pain in patients with chronic interstitial lung disease—an underestimated symptom
IntroductionPrevalence and predisposing factors for the development of thoracic pain (TP) in patients with chronic interstitial lung disease (cILD) are largely unknown. Underestimation and insufficient therapy of pain can lead to worsened ventilatory function. Quantitative sensory testing is an esta...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1147555/full |
| _version_ | 1797833013928656896 |
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| author | Manuela J. Scherer Sandra Kampe Sandra Kampe Jonas Fredebeul-Beverungen Gerhard Weinreich Ulrich Costabel Francesco Bonella |
| author_facet | Manuela J. Scherer Sandra Kampe Sandra Kampe Jonas Fredebeul-Beverungen Gerhard Weinreich Ulrich Costabel Francesco Bonella |
| author_sort | Manuela J. Scherer |
| collection | DOAJ |
| description | IntroductionPrevalence and predisposing factors for the development of thoracic pain (TP) in patients with chronic interstitial lung disease (cILD) are largely unknown. Underestimation and insufficient therapy of pain can lead to worsened ventilatory function. Quantitative sensory testing is an established tool for characterization of chronic pain and its neuropathic components. We investigated frequency and intensity of TP in cILD patients and the potential association with lung function and quality of life.Materials and methodsWe prospectively investigated patients with chronic interstitial lung disease to analyze risk factors for the development of thoracic pain and quantify thoracic pain through quantitative sensory testing. In addition, we studied the relationship between pain sensitivity and lung function impairment.ResultsSeventy-eight patients with chronic interstitial lung disease and 36 healthy controls (HCs) were included. Thoracic pain occurred in 38 of 78 patients (49%), most frequently in 13 of 18 (72%, p = 0.02) patients with pulmonary sarcoidosis. The occurrence was mostly spontaneous and not related to thoracic surgical interventions (76%, p = 0.48). Patients with thoracic pain showed a significant impairment of mental well-being (p = 0.004). A higher sensitivity to pinprick stimulation during QST can be observed in patients with thoracic pain (p < 0.001). Steroid treatment was associated with lower sensitivity within thermal (p = 0.034 and p = 0.032) and pressure pain testing (p = 0.046). We observed a significant correlation between total lung capacity and thermal (p = 0.019 and p = 0.03) or pressure pain sensitivity (p = 0.006 and p = 0.024).ConclusionThis study was performed to investigate prevalence, risk factors and thoracic pain in patients with chronic interstitial lung disease. Thoracic pain mostly occurs spontaneous as a frequent symptom, and seems to be an underestimated symptom in patients with chronic interstitial lung disease, especially those with pulmonary sarcoidosis. Timely identification of thoracic pain may allow starting symptomatic treatment at early stage, before impairment in quality of life occurs.Clinical Trial Registrationhttps://www.drks.de/drks_web/, Deutsches Register Klinischer Studien (DRKS) DRKS00022978. |
| first_indexed | 2024-04-09T14:18:01Z |
| format | Article |
| id | doaj.art-00253786ace64fb39673e068f70533b5 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-09T14:18:01Z |
| publishDate | 2023-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-00253786ace64fb39673e068f70533b52023-05-05T05:41:31ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-05-011010.3389/fmed.2023.11475551147555Thoracic pain in patients with chronic interstitial lung disease—an underestimated symptomManuela J. Scherer0Sandra Kampe1Sandra Kampe2Jonas Fredebeul-Beverungen3Gerhard Weinreich4Ulrich Costabel5Francesco Bonella6Department of Anaesthesiology and Pain Medicine, University Medicine Essen—Ruhrlandklinik, University Duisburg-Essen, Essen, GermanyDepartment of Anaesthesiology and Pain Medicine, University Medicine Essen—Ruhrlandklinik, University Duisburg-Essen, Essen, GermanyDepartment of Anaesthesiology and Intensive Care Medicine, University Hospital Magdeburg, Otto von Guericke University Magdeburg, Magdeburg, GermanyDepartment of Anaesthesiology and Pain Medicine, University Medicine Essen—Ruhrlandklinik, University Duisburg-Essen, Essen, GermanyPneumology Department, University Medicine Essen—Ruhrlandklinik, University Duisburg-Essen, Essen, GermanyPneumology Department, Center for Interstitial and Rare Lung Diseases, University Medicine Essen—Ruhrlandklinik, University Duisburg-Essen, Essen, GermanyPneumology Department, Center for Interstitial and Rare Lung Diseases, University Medicine Essen—Ruhrlandklinik, University Duisburg-Essen, Essen, GermanyIntroductionPrevalence and predisposing factors for the development of thoracic pain (TP) in patients with chronic interstitial lung disease (cILD) are largely unknown. Underestimation and insufficient therapy of pain can lead to worsened ventilatory function. Quantitative sensory testing is an established tool for characterization of chronic pain and its neuropathic components. We investigated frequency and intensity of TP in cILD patients and the potential association with lung function and quality of life.Materials and methodsWe prospectively investigated patients with chronic interstitial lung disease to analyze risk factors for the development of thoracic pain and quantify thoracic pain through quantitative sensory testing. In addition, we studied the relationship between pain sensitivity and lung function impairment.ResultsSeventy-eight patients with chronic interstitial lung disease and 36 healthy controls (HCs) were included. Thoracic pain occurred in 38 of 78 patients (49%), most frequently in 13 of 18 (72%, p = 0.02) patients with pulmonary sarcoidosis. The occurrence was mostly spontaneous and not related to thoracic surgical interventions (76%, p = 0.48). Patients with thoracic pain showed a significant impairment of mental well-being (p = 0.004). A higher sensitivity to pinprick stimulation during QST can be observed in patients with thoracic pain (p < 0.001). Steroid treatment was associated with lower sensitivity within thermal (p = 0.034 and p = 0.032) and pressure pain testing (p = 0.046). We observed a significant correlation between total lung capacity and thermal (p = 0.019 and p = 0.03) or pressure pain sensitivity (p = 0.006 and p = 0.024).ConclusionThis study was performed to investigate prevalence, risk factors and thoracic pain in patients with chronic interstitial lung disease. Thoracic pain mostly occurs spontaneous as a frequent symptom, and seems to be an underestimated symptom in patients with chronic interstitial lung disease, especially those with pulmonary sarcoidosis. Timely identification of thoracic pain may allow starting symptomatic treatment at early stage, before impairment in quality of life occurs.Clinical Trial Registrationhttps://www.drks.de/drks_web/, Deutsches Register Klinischer Studien (DRKS) DRKS00022978.https://www.frontiersin.org/articles/10.3389/fmed.2023.1147555/fullchronic interstitial lung diseasethoracic painprevalence of thoracic painrisk factorsquantitative sensory testing |
| spellingShingle | Manuela J. Scherer Sandra Kampe Sandra Kampe Jonas Fredebeul-Beverungen Gerhard Weinreich Ulrich Costabel Francesco Bonella Thoracic pain in patients with chronic interstitial lung disease—an underestimated symptom Frontiers in Medicine chronic interstitial lung disease thoracic pain prevalence of thoracic pain risk factors quantitative sensory testing |
| title | Thoracic pain in patients with chronic interstitial lung disease—an underestimated symptom |
| title_full | Thoracic pain in patients with chronic interstitial lung disease—an underestimated symptom |
| title_fullStr | Thoracic pain in patients with chronic interstitial lung disease—an underestimated symptom |
| title_full_unstemmed | Thoracic pain in patients with chronic interstitial lung disease—an underestimated symptom |
| title_short | Thoracic pain in patients with chronic interstitial lung disease—an underestimated symptom |
| title_sort | thoracic pain in patients with chronic interstitial lung disease an underestimated symptom |
| topic | chronic interstitial lung disease thoracic pain prevalence of thoracic pain risk factors quantitative sensory testing |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1147555/full |
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