Renal function and cardiovascular risk in rheumatoid arthritis
Aim. To study renal function and its association with cardiovascular risk factors in rheumatoid arthritis (RA). Material and methods. The study included 257 RA patients aged 29—69 years. Results. Reduced glomerular filtration rate (GFR) <60 ml/min was observed in 146 (56,8 %) RA patients. Ren...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2010-10-01
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| Series: | Кардиоваскулярная терапия и профилактика |
| Subjects: | |
| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/2123 |
| _version_ | 1827063933699096576 |
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| author | N. A. Khramtsova A. A. Dzizinsky |
| author_facet | N. A. Khramtsova A. A. Dzizinsky |
| author_sort | N. A. Khramtsova |
| collection | DOAJ |
| description | Aim. To study renal function and its association with cardiovascular risk factors in rheumatoid arthritis (RA). Material and methods. The study included 257 RA patients aged 29—69 years. Results. Reduced glomerular filtration rate (GFR) <60 ml/min was observed in 146 (56,8 %) RA patients. Renal dysfunction was associated with non-steroid anti-inflammatory drug (NSAID) therapy (OR 24,5; p<0,01), microalbuminuria (OR 17,8; p<0,01), high RA activity by DAS 28 (OR 6,1; p<0,01), pulse blood pressure (PBP) >55 mm Hg (OR 4,38; p<0,01), arterial hypertension (AH) (OR 3,15; p<0,01), atherogenic dyslipidemia (DLP) (OR 2,83; p<0,01), RA duration >10 years (OR 2,8; p<0,01), hyperglycaemia (OR 2,35; p<0,05), age >50 years (OR 2,17; p<0,01) and “non-dipper” BP profile (OR 1,85; p<0,05). GFR negatively correlated with vascular stiffness index (r=-0,23; p<0,01), LV myocardial mass index (r=-0,2; p<0,05), C-reactive protein level (r=-0,31; p<0,01), RA activity by DAS 28 (r=-0,29; p<0,01), age (r=-0,33; p<0,01), RA duration (r=-0,29; p<0,01), intima-media thickness (IMT) (r=-0,28; p<0,01), mean circadian systolic BP level (r=-0,19; p<0,05) and PBP level (r=-0,31; p<0,01), as well as SCORE-assessed cardiovascular risk level (r=-0,17; p<0,05). Conclusion. In RA, GFR reduction is a complication of chronic inflammation and long-term NSAID therapy. It is associated with AH, atherogenic DLP, and high cardiovascular risk. |
| first_indexed | 2024-04-10T03:37:56Z |
| format | Article |
| id | doaj.art-0025c00c42b149f69e92b09909242cd5 |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2025-03-19T22:39:07Z |
| publishDate | 2010-10-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-0025c00c42b149f69e92b09909242cd52024-10-17T12:21:29Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252010-10-019547521832Renal function and cardiovascular risk in rheumatoid arthritisN. A. Khramtsova0A. A. Dzizinsky1Irkutsk State Institute of Medical Post-Diploma Education. IrkutskIrkutsk State Institute of Medical Post-Diploma Education. IrkutskAim. To study renal function and its association with cardiovascular risk factors in rheumatoid arthritis (RA). Material and methods. The study included 257 RA patients aged 29—69 years. Results. Reduced glomerular filtration rate (GFR) <60 ml/min was observed in 146 (56,8 %) RA patients. Renal dysfunction was associated with non-steroid anti-inflammatory drug (NSAID) therapy (OR 24,5; p<0,01), microalbuminuria (OR 17,8; p<0,01), high RA activity by DAS 28 (OR 6,1; p<0,01), pulse blood pressure (PBP) >55 mm Hg (OR 4,38; p<0,01), arterial hypertension (AH) (OR 3,15; p<0,01), atherogenic dyslipidemia (DLP) (OR 2,83; p<0,01), RA duration >10 years (OR 2,8; p<0,01), hyperglycaemia (OR 2,35; p<0,05), age >50 years (OR 2,17; p<0,01) and “non-dipper” BP profile (OR 1,85; p<0,05). GFR negatively correlated with vascular stiffness index (r=-0,23; p<0,01), LV myocardial mass index (r=-0,2; p<0,05), C-reactive protein level (r=-0,31; p<0,01), RA activity by DAS 28 (r=-0,29; p<0,01), age (r=-0,33; p<0,01), RA duration (r=-0,29; p<0,01), intima-media thickness (IMT) (r=-0,28; p<0,01), mean circadian systolic BP level (r=-0,19; p<0,05) and PBP level (r=-0,31; p<0,01), as well as SCORE-assessed cardiovascular risk level (r=-0,17; p<0,05). Conclusion. In RA, GFR reduction is a complication of chronic inflammation and long-term NSAID therapy. It is associated with AH, atherogenic DLP, and high cardiovascular risk.https://cardiovascular.elpub.ru/jour/article/view/2123rheumatoid arthritisglomerular filtration ratecardiovascular risk |
| spellingShingle | N. A. Khramtsova A. A. Dzizinsky Renal function and cardiovascular risk in rheumatoid arthritis Кардиоваскулярная терапия и профилактика rheumatoid arthritis glomerular filtration rate cardiovascular risk |
| title | Renal function and cardiovascular risk in rheumatoid arthritis |
| title_full | Renal function and cardiovascular risk in rheumatoid arthritis |
| title_fullStr | Renal function and cardiovascular risk in rheumatoid arthritis |
| title_full_unstemmed | Renal function and cardiovascular risk in rheumatoid arthritis |
| title_short | Renal function and cardiovascular risk in rheumatoid arthritis |
| title_sort | renal function and cardiovascular risk in rheumatoid arthritis |
| topic | rheumatoid arthritis glomerular filtration rate cardiovascular risk |
| url | https://cardiovascular.elpub.ru/jour/article/view/2123 |
| work_keys_str_mv | AT nakhramtsova renalfunctionandcardiovascularriskinrheumatoidarthritis AT aadzizinsky renalfunctionandcardiovascularriskinrheumatoidarthritis |