Caenorhabditis elegans Neurotoxicity Testing: Novel Applications in the Adverse Outcome Pathway Framework

Caenorhabditis elegans Neurotoxicity Testing: Novel Applications in the Adverse Outcome Pathway Framework

Neurological hazard assessment of industrial and pesticidal chemicals demands a substantial amount of time and resources. Caenorhabditis elegans is an established model organism in developmental biology and neuroscience. It presents an ideal test system with relatively fewer neurons (302 in hermaphr...

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Bibliographic Details
Main Authors:	Shreesh Raj Sammi, Laura E. Jameson, Kendra D. Conrow, Maxwell C. K. Leung, Jason R. Cannon
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-03-01
Series:	Frontiers in Toxicology
Subjects:	pesticides adverse outcome pathway chlorpyrifos dopamine acetylcholine new approach methodologies (NAM)
Online Access:	https://www.frontiersin.org/articles/10.3389/ftox.2022.826488/full

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