Sensitive extraction spectrophotometric methods for the determination of trazodone hydrochloride in pure and pharmaceutical formulations
Two simple, rapid and sensitive extraction spectrophotometric methods have been developed for the assay of trazodone hydrochloride (TRH) in pure and pharmaceutical formulations. These methods are based on the formation of chloroform soluble ion-association complexes of TRH with bromocresol green (BC...
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| Format: | Article |
| Language: | English |
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Serbian Chemical Society
2006-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2006/0352-51390607829H.pdf |
| _version_ | 1818293415247347712 |
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| author | Harikrishna K. Kumar Sudhir R. Seetharamappa J. Manjunatha D.H. |
| author_facet | Harikrishna K. Kumar Sudhir R. Seetharamappa J. Manjunatha D.H. |
| author_sort | Harikrishna K. |
| collection | DOAJ |
| description | Two simple, rapid and sensitive extraction spectrophotometric methods have been developed for the assay of trazodone hydrochloride (TRH) in pure and pharmaceutical formulations. These methods are based on the formation of chloroform soluble ion-association complexes of TRH with bromocresol green (BCG) and with methyl orange (MO) in a KCl-HCl buffer of pH 1.5 (for BCG) and in a NaOAc-HCl buffer of pH 3.29 (for MO) with absorption maximum at 415 nm and at 422 nm for BCG and MO, respectively. The reaction conditions were optimized to obtain the maximum color intensity. The absorbance was found to increase linearly with increasing concentration of TRH, which was corroborated by the calculated correlation coefficient values (0.9992 and 0.9994). The systems obeyed the Beer law in the range of 0.9-17 and 1-20 μg/ml for BCG and MO, respectively. Various analytical parameters were evaluated and the results were validated by statistical data. No interference was observed from common excipients present in pharmaceutical formulations. The proposed methods are simple, accurate and suitable for quality control applications. |
| first_indexed | 2024-12-13T03:15:29Z |
| format | Article |
| id | doaj.art-0025fc5b371b4915959e6b2f69efd7ae |
| institution | Directory Open Access Journal |
| issn | 0352-5139 1820-7421 |
| language | English |
| last_indexed | 2024-12-13T03:15:29Z |
| publishDate | 2006-01-01 |
| publisher | Serbian Chemical Society |
| record_format | Article |
| series | Journal of the Serbian Chemical Society |
| spelling | doaj.art-0025fc5b371b4915959e6b2f69efd7ae2022-12-22T00:01:29ZengSerbian Chemical SocietyJournal of the Serbian Chemical Society0352-51391820-74212006-01-0171782983710.2298/JSC0607829H0352-51390607829HSensitive extraction spectrophotometric methods for the determination of trazodone hydrochloride in pure and pharmaceutical formulationsHarikrishna K.0Kumar Sudhir R.1Seetharamappa J.2Manjunatha D.H.3Department of Chemistry, Karnatak University, DharwadDepartment of Chemistry, Karnatak University, DharwadDepartment of Chemistry, Karnatak University, DharwadDepartment of Chemistry, Karnatak University, DharwadTwo simple, rapid and sensitive extraction spectrophotometric methods have been developed for the assay of trazodone hydrochloride (TRH) in pure and pharmaceutical formulations. These methods are based on the formation of chloroform soluble ion-association complexes of TRH with bromocresol green (BCG) and with methyl orange (MO) in a KCl-HCl buffer of pH 1.5 (for BCG) and in a NaOAc-HCl buffer of pH 3.29 (for MO) with absorption maximum at 415 nm and at 422 nm for BCG and MO, respectively. The reaction conditions were optimized to obtain the maximum color intensity. The absorbance was found to increase linearly with increasing concentration of TRH, which was corroborated by the calculated correlation coefficient values (0.9992 and 0.9994). The systems obeyed the Beer law in the range of 0.9-17 and 1-20 μg/ml for BCG and MO, respectively. Various analytical parameters were evaluated and the results were validated by statistical data. No interference was observed from common excipients present in pharmaceutical formulations. The proposed methods are simple, accurate and suitable for quality control applications.http://www.doiserbia.nb.rs/img/doi/0352-5139/2006/0352-51390607829H.pdfsprectrophotometric determinationtrazodone hydrochloride |
| spellingShingle | Harikrishna K. Kumar Sudhir R. Seetharamappa J. Manjunatha D.H. Sensitive extraction spectrophotometric methods for the determination of trazodone hydrochloride in pure and pharmaceutical formulations Journal of the Serbian Chemical Society sprectrophotometric determination trazodone hydrochloride |
| title | Sensitive extraction spectrophotometric methods for the determination of trazodone hydrochloride in pure and pharmaceutical formulations |
| title_full | Sensitive extraction spectrophotometric methods for the determination of trazodone hydrochloride in pure and pharmaceutical formulations |
| title_fullStr | Sensitive extraction spectrophotometric methods for the determination of trazodone hydrochloride in pure and pharmaceutical formulations |
| title_full_unstemmed | Sensitive extraction spectrophotometric methods for the determination of trazodone hydrochloride in pure and pharmaceutical formulations |
| title_short | Sensitive extraction spectrophotometric methods for the determination of trazodone hydrochloride in pure and pharmaceutical formulations |
| title_sort | sensitive extraction spectrophotometric methods for the determination of trazodone hydrochloride in pure and pharmaceutical formulations |
| topic | sprectrophotometric determination trazodone hydrochloride |
| url | http://www.doiserbia.nb.rs/img/doi/0352-5139/2006/0352-51390607829H.pdf |
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