B cell receptor signaling pathway involved in benign lymphoepithelial lesions of the lacrimal gland
AIM: To detect the expression of B cell receptor signaling pathway (BCRSP) in lacrimal gland benign lymphoepithelial lesions (LGBLEL). METHODS: Gene microarray was used to compare whole-genome expression in lacrimal gland tissues from LGBLEL patients to tissues from orbital cavernous hemangioma (co...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2017-05-01
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| Series: | International Journal of Ophthalmology |
| Subjects: | |
| Online Access: | http://www.ijo.cn/en_publish/2017/5/20170501.pdf |
| _version_ | 1828514829237747712 |
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| author | Xiao-Na Wang Xin Ge Jing Li Xiao Liu Jian-Min Ma |
| author_facet | Xiao-Na Wang Xin Ge Jing Li Xiao Liu Jian-Min Ma |
| author_sort | Xiao-Na Wang |
| collection | DOAJ |
| description | AIM: To detect the expression of B cell receptor signaling pathway (BCRSP) in lacrimal gland benign lymphoepithelial lesions (LGBLEL).
METHODS: Gene microarray was used to compare whole-genome expression in lacrimal gland tissues from LGBLEL patients to tissues from orbital cavernous hemangioma (control tissues). Expression of BCRSP was confirmed by polymerase chain reaction (PCR) and immunohistochemistry.
RESULTS: The expression of 22 genes of the BCRSP increased significantly in LGBLEL patients. PCR analysis showed that CD22, CR2, and BTK were all highly expressed in LGBLEL tissues. Immunohistochemical analysis showed that CR2 protein was present in LGBLEL, but CD22 and BTK proteins were negative. CR2, CD22, and BTK were not observed in the orbital cavernous hemangiomas with either PCR or immunohistochemistry.
CONCLUSION: BCRSP might be involved in the pathogenesis of LGBLEL. |
| first_indexed | 2024-12-11T18:05:18Z |
| format | Article |
| id | doaj.art-002675980dc64664a8586c5d6764ed86 |
| institution | Directory Open Access Journal |
| issn | 2222-3959 2227-4898 |
| language | English |
| last_indexed | 2024-12-11T18:05:18Z |
| publishDate | 2017-05-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | International Journal of Ophthalmology |
| spelling | doaj.art-002675980dc64664a8586c5d6764ed862022-12-22T00:55:45ZengPress of International Journal of Ophthalmology (IJO PRESS)International Journal of Ophthalmology2222-39592227-48982017-05-0110566566910.18240/ijo.2017.05.01B cell receptor signaling pathway involved in benign lymphoepithelial lesions of the lacrimal glandXiao-Na Wang0Xin Ge1Jing Li2Xiao Liu3Jian-Min Ma4Beijing Tongren Eye Center, Beijing Institute of Ophthal-mology, Beijing Tongren Hospital, Beijing Ophthalmology &Vision Science Key Lab, Capital Medical University, Beijing 100730, ChinaBeijing Tongren Eye Center, Beijing Institute of Ophthal-mology, Beijing Tongren Hospital, Beijing Ophthalmology &Vision Science Key Lab, Capital Medical University, Beijing 100730, ChinaBeijing Tongren Eye Center, Beijing Institute of Ophthal-mology, Beijing Tongren Hospital, Beijing Ophthalmology &Vision Science Key Lab, Capital Medical University, Beijing 100730, ChinaBeijing Tongren Eye Center, Beijing Institute of Ophthal-mology, Beijing Tongren Hospital, Beijing Ophthalmology &Vision Science Key Lab, Capital Medical University, Beijing 100730, ChinaBeijing Tongren Eye Center, Beijing Institute of Ophthal-mology, Beijing Tongren Hospital, Beijing Ophthalmology &Vision Science Key Lab, Capital Medical University, Beijing 100730, ChinaAIM: To detect the expression of B cell receptor signaling pathway (BCRSP) in lacrimal gland benign lymphoepithelial lesions (LGBLEL). METHODS: Gene microarray was used to compare whole-genome expression in lacrimal gland tissues from LGBLEL patients to tissues from orbital cavernous hemangioma (control tissues). Expression of BCRSP was confirmed by polymerase chain reaction (PCR) and immunohistochemistry. RESULTS: The expression of 22 genes of the BCRSP increased significantly in LGBLEL patients. PCR analysis showed that CD22, CR2, and BTK were all highly expressed in LGBLEL tissues. Immunohistochemical analysis showed that CR2 protein was present in LGBLEL, but CD22 and BTK proteins were negative. CR2, CD22, and BTK were not observed in the orbital cavernous hemangiomas with either PCR or immunohistochemistry. CONCLUSION: BCRSP might be involved in the pathogenesis of LGBLEL.http://www.ijo.cn/en_publish/2017/5/20170501.pdf669lacrimal glandbenign lymphoepithelial lesionB cell receptor signaling pathwaypathogenesis |
| spellingShingle | Xiao-Na Wang Xin Ge Jing Li Xiao Liu Jian-Min Ma B cell receptor signaling pathway involved in benign lymphoepithelial lesions of the lacrimal gland International Journal of Ophthalmology 669 lacrimal gland benign lymphoepithelial lesion B cell receptor signaling pathway pathogenesis |
| title | B cell receptor signaling pathway involved in benign lymphoepithelial lesions of the lacrimal gland |
| title_full | B cell receptor signaling pathway involved in benign lymphoepithelial lesions of the lacrimal gland |
| title_fullStr | B cell receptor signaling pathway involved in benign lymphoepithelial lesions of the lacrimal gland |
| title_full_unstemmed | B cell receptor signaling pathway involved in benign lymphoepithelial lesions of the lacrimal gland |
| title_short | B cell receptor signaling pathway involved in benign lymphoepithelial lesions of the lacrimal gland |
| title_sort | b cell receptor signaling pathway involved in benign lymphoepithelial lesions of the lacrimal gland |
| topic | 669 lacrimal gland benign lymphoepithelial lesion B cell receptor signaling pathway pathogenesis |
| url | http://www.ijo.cn/en_publish/2017/5/20170501.pdf |
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