Vascular Inflammatory Diseases and Endothelial Phenotypes
The physiological functions of endothelial cells control vascular tone, permeability, inflammation, and angiogenesis, which significantly help to maintain a healthy vascular system. Several cardiovascular diseases are characterized by endothelial cell activation or dysfunction triggered by external...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/12/1640 |
| _version_ | 1797595568676012032 |
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| author | Jenita Immanuel Sanguk Yun |
| author_facet | Jenita Immanuel Sanguk Yun |
| author_sort | Jenita Immanuel |
| collection | DOAJ |
| description | The physiological functions of endothelial cells control vascular tone, permeability, inflammation, and angiogenesis, which significantly help to maintain a healthy vascular system. Several cardiovascular diseases are characterized by endothelial cell activation or dysfunction triggered by external stimuli such as disturbed flow, hypoxia, growth factors, and cytokines in response to high levels of low-density lipoprotein and cholesterol, hypertension, diabetes, aging, drugs, and smoking. Increasing evidence suggests that uncontrolled proinflammatory signaling and further alteration in endothelial cell phenotypes such as barrier disruption, increased permeability, endothelial to mesenchymal transition (EndMT), and metabolic reprogramming further induce vascular diseases, and multiple studies are focusing on finding the pathways and mechanisms involved in it. This review highlights the main proinflammatory stimuli and their effects on endothelial cell function. In order to provide a rational direction for future research, we also compiled the most recent data regarding the impact of endothelial cell dysfunction on vascular diseases and potential targets that impede the pathogenic process. |
| first_indexed | 2024-03-11T02:38:25Z |
| format | Article |
| id | doaj.art-0027a03b41154847b4eed0124ceab61d |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T02:38:25Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-0027a03b41154847b4eed0124ceab61d2023-11-18T09:43:49ZengMDPI AGCells2073-44092023-06-011212164010.3390/cells12121640Vascular Inflammatory Diseases and Endothelial PhenotypesJenita Immanuel0Sanguk Yun1Department of Biotechnology, Inje University, Gimhae-si 50834, Republic of KoreaDepartment of Biotechnology, Inje University, Gimhae-si 50834, Republic of KoreaThe physiological functions of endothelial cells control vascular tone, permeability, inflammation, and angiogenesis, which significantly help to maintain a healthy vascular system. Several cardiovascular diseases are characterized by endothelial cell activation or dysfunction triggered by external stimuli such as disturbed flow, hypoxia, growth factors, and cytokines in response to high levels of low-density lipoprotein and cholesterol, hypertension, diabetes, aging, drugs, and smoking. Increasing evidence suggests that uncontrolled proinflammatory signaling and further alteration in endothelial cell phenotypes such as barrier disruption, increased permeability, endothelial to mesenchymal transition (EndMT), and metabolic reprogramming further induce vascular diseases, and multiple studies are focusing on finding the pathways and mechanisms involved in it. This review highlights the main proinflammatory stimuli and their effects on endothelial cell function. In order to provide a rational direction for future research, we also compiled the most recent data regarding the impact of endothelial cell dysfunction on vascular diseases and potential targets that impede the pathogenic process.https://www.mdpi.com/2073-4409/12/12/1640endothelial cellinflammationEC phenotypesvascular diseases |
| spellingShingle | Jenita Immanuel Sanguk Yun Vascular Inflammatory Diseases and Endothelial Phenotypes Cells endothelial cell inflammation EC phenotypes vascular diseases |
| title | Vascular Inflammatory Diseases and Endothelial Phenotypes |
| title_full | Vascular Inflammatory Diseases and Endothelial Phenotypes |
| title_fullStr | Vascular Inflammatory Diseases and Endothelial Phenotypes |
| title_full_unstemmed | Vascular Inflammatory Diseases and Endothelial Phenotypes |
| title_short | Vascular Inflammatory Diseases and Endothelial Phenotypes |
| title_sort | vascular inflammatory diseases and endothelial phenotypes |
| topic | endothelial cell inflammation EC phenotypes vascular diseases |
| url | https://www.mdpi.com/2073-4409/12/12/1640 |
| work_keys_str_mv | AT jenitaimmanuel vascularinflammatorydiseasesandendothelialphenotypes AT sangukyun vascularinflammatorydiseasesandendothelialphenotypes |