Modulation of calcium-binding proteins expression and cisplatin chemosensitivity by calcium chelation in human breast cancer MCF-7 cells

Modulation of calcium-binding proteins expression and cisplatin chemosensitivity by calcium chelation in human breast cancer MCF-7 cells

Cisplatin (CDDP) is currently one of the most effective FDA-approved treatments for breast cancer. Previous studies have shown that CDDP-induced cell death in human breast cancer (MCF-7) cells is associated with disruption of calcium homeostasis. However, whether the sensitivity of breast cancer cel...

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Bibliographic Details
Main Authors: Rawad Hodeify, Shoib Sarwar Siddiqui, Rachel Matar, Cijo George Vazhappilly, Maxime Merheb, Hussain Al Zouabi, John Marton
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Heliyon
Subjects:
Cisplatin
Calcium-binding proteins
BAPTA-AM
Intracellular calcium
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844021001468

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