The Impact of Efflux Pump Inhibitors on the Activity of Selected Non-Antibiotic Medicinal Products against Gram-Negative Bacteria

The Impact of Efflux Pump Inhibitors on the Activity of Selected Non-Antibiotic Medicinal Products against Gram-Negative Bacteria

The potential role of non-antibiotic medicinal products in the treatment of multidrug-resistant Gram-negative bacteria has recently been investigated. It is highly likely that the presence of efflux pumps may be one of the reasons for the weak activity of non-antibiotics, as in the case of some non-...

Full description

Bibliographic Details
Main Authors:	Agnieszka E. Laudy, Ewa Kulińska, Stefan Tyski
Format:	Article
Language:	English
Published:	MDPI AG 2017-01-01
Series:	Molecules
Subjects:	efflux efflux pump inhibitor non-antibiotics medicinal products Gram-negative bacteria MDR PAβN drugs quinolones
Online Access:	http://www.mdpi.com/1420-3049/22/1/114

Similar Items

Non-antibiotics, Efflux Pumps and Drug Resistance of Gram-negative Rods
by: AGNIESZKA EWA LAUDY
Published: (2018-06-01)

Update on the Discovery of Efflux Pump Inhibitors against Critical Priority Gram-Negative Bacteria
by: Nina Compagne, et al.
Published: (2023-01-01)

Efflux pump blockers in Gram-negative bacteria:The new generation of hydantoin based-modulators to improve antibiotic activity
by: Ewa eOtrębska-Machaj, et al.
Published: (2016-05-01)

Multidrug Efflux Pumps in Bacteria and Efflux Pump Inhibitors
by: Sreekantan Abhirami P., et al.
Published: (2022-10-01)

The Contribution of Efflux Systems to Levofloxacin Resistance in <i>Stenotrophomonas maltophilia</i> Clinical Strains Isolated in Warsaw, Poland
by: Olga M. Zając, et al.
Published: (2022-07-01)

Effectiveness of Efflux Pump Inhibitors as Biofilm Disruptors and Resistance Breakers in Gram-Negative (ESKAPEE) Bacteria
by: Akif Reza, et al.
Published: (2019-11-01)

Efflux Pumps of Gram-negative bacteria: What they do, how they do it, with what and how to deal with them
by: Leonard eAmaral, et al.
Published: (2014-01-01)

The culmination of multidrug-resistant efflux pumps vs. meager antibiotic arsenal era: Urgent need for an improved new generation of EPIs
by: Shiela Chetri
Published: (2023-04-01)

The Role of Efflux Pumps in the Transition from Low-Level to Clinical Antibiotic Resistance
by: Anna Elisabeth Ebbensgaard, et al.
Published: (2020-11-01)

Clinical Status of Efflux Resistance Mechanisms in Gram-Negative Bacteria
by: Anne Davin-Regli, et al.
Published: (2021-09-01)

RND-type Drug Efflux Pumps from Gram-negative bacteria: Molecular Mechanism and Inhibition
by: Henrietta eVenter, et al.
Published: (2015-04-01)

Recent Advances in Multi-Drug Resistance (MDR) Efflux Pump Inhibitors of Gram-Positive Bacteria S. aureus
by: Katarzyna Kieć-Kononowicz, et al.
Published: (2013-02-01)

Antibacterial activities and ciprofloxacin potentiation of Melissa officinalis extracts against some gram negative pathogenic bacteria
by: Azizollah Ebrahimi, et al.
Published: (2019-03-01)

Function and Inhibitory Mechanisms of Multidrug Efflux Pumps
by: Kunihiko Nishino, et al.
Published: (2021-12-01)

Quinolone resistance: much more than predicted
by: Alvaro eHernandez, et al.
Published: (2011-02-01)

Phenotypic and Genotypic Efflux Pumps in Resistance to Fluoroquinolones in E.coli Isolated from Inpatients in Kermanshah Hospitals in 2013
by: Maryam Doosti Mohajer, et al.
Published: (2017-12-01)

The Properties of Linezolid, Rifampicin, and Vancomycin, as Well as the Mechanism of Action of Pentamidine, Determine Their Synergy against Gram-Negative Bacteria
by: Miran Tang, et al.
Published: (2023-09-01)

The nature and epidemiology of OqxAB, a multidrug efflux pump
by: Jun Li, et al.
Published: (2019-02-01)

What Approaches to Thwart Bacterial Efflux Pumps-Mediated Resistance?
by: Armel Jackson Seukep, et al.
Published: (2022-09-01)

Chlorpromazine and Amitriptyline Are Substrates and Inhibitors of the AcrB Multidrug Efflux Pump
by: Elizabeth M. Grimsey, et al.
Published: (2020-06-01)

Acinetobacter baumannii Efflux Pumps and Antibiotic Resistance
by: Abdi SN, et al.
Published: (2020-02-01)

Tigecycline Resistance-Associated Mutations in the MepA Efflux Pump in Staphylococcus aureus
by: Honghao Huang, et al.
Published: (2023-08-01)

Microbial Efflux Pump Inhibitors: A Journey around Quinoline and Indole Derivatives
by: Giada Cernicchi, et al.
Published: (2021-11-01)

Efflux pumps as potential targets for biofilm inhibition
by: Jingyi Ren, et al.
Published: (2024-02-01)

Bacterial Multidrug Efflux Pumps: Much More Than Antibiotic Resistance Determinants
by: Paula Blanco, et al.
Published: (2016-02-01)

Investigation of the Rv3065, Rv2942, Rv1258c, Rv1410c, and Rv2459 efflux pump genes expression among multidrug-resistant Mycobacterium tuberculosis clinical isolates
by: Fatemeh Shahi, et al.
Published: (2021-07-01)

Types and Mechanisms of Efflux Pump Systems and the Potential of Efflux Pump Inhibitors in the Restoration of Antimicrobial Susceptibility, with a Special Reference to <i>Acinetobacter baumannii</i>
by: Kira M. Zack, et al.
Published: (2024-02-01)

Antibiotic resistance in Salmonella: Targeting multidrug resistance by understanding efflux pumps, regulators and the inhibitors
by: Rawaf Alenazy
Published: (2022-10-01)

Advances in the Discovery of Efflux Pump Inhibitors as Novel Potentiators to Control Antimicrobial-Resistant Pathogens
by: Song Zhang, et al.
Published: (2023-09-01)

Bad bugs in the XXIst century: resistance mediated by multi-drug efflux pumps in Gram-negative bacteria
by: Attilio Vittorio Vargiu, et al.
Published: (2016-05-01)

Efflux pump activity, biofilm formation and antibiotic resistance profile of Klebsiella spp. isolated from clinical samples at Lagos University Teaching Hospital
by: Sharon Akinpelu, et al.
Published: (2020-05-01)

Reducing bacterial antibiotic resistance by targeting bacterial metabolic pathways and disrupting RND efflux pump activity
by: Tatiana Hillman
Published: (2022-01-01)

EmrR-Dependent Upregulation of the Efflux Pump EmrCAB Contributes to Antibiotic Resistance in Chromobacterium violaceum
by: Kelly C. M. Barroso, et al.
Published: (2018-11-01)

Drug Efflux Pump Inhibitors: A Promising Approach to Counter Multidrug Resistance in Gram-Negative Pathogens by Targeting AcrB Protein from AcrAB-TolC Multidrug Efflux Pump from <i>Escherichia coli</i>
by: Rawaf Alenazy
Published: (2022-09-01)

Characterization and Molecular Determinants for β-Lactam Specificity of the Multidrug Efflux Pump AcrD from <i>Salmonella typhimurium</i>
by: Jenifer Cuesta Bernal, et al.
Published: (2021-12-01)

Scrutinizing the drug resistance mechanism of multi- and extensively-drug resistant Mycobacterium tuberculosis: mutations versus efflux pumps
by: Hasan Ghajavand, et al.
Published: (2019-05-01)

Molecular determinants of avoidance and inhibition of Pseudomonas aeruginosa MexB efflux pump
by: Silvia Gervasoni, et al.
Published: (2023-08-01)

Efflux pump inhibitors (EPIs) as new antimicrobial agents against Pseudomonas aeruginosa
by: Momen Askoura, et al.
Published: (2011-05-01)

Unraveling antibiotic resistance mechanisms in Mycobacterium abscessus: the potential role of efflux pumps
by: Saskia E. Mudde, et al.
Published: (2022-12-01)

Mutations in the TolC Periplasmic Domain Affect Substrate Specificity of the AcrAB-TolC Pump
by: Robert L. Marshall, et al.
Published: (2020-07-01)