Association between short-term blood pressure variability and target organ damage in non-dialysis patients with chronic kidney disease
Abstract Background It is unclear whether short-term blood pressure variability (BPV) is associated with target organ damage in patients with non-dialysis chronic kidney disease (CKD). Methods A cross-sectional, single-center study was conducted among 3442 non-dialysis CKD patients hospitalized in t...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-03-01
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| Series: | BMC Nephrology |
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| Online Access: | https://doi.org/10.1186/s12882-024-03541-x |
| _version_ | 1827310310363496448 |
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| author | Zhaoting Chen Xinying Jiang Jingcan Wu Lin Lin Zhengping Zhou Man Li Cheng Wang |
| author_facet | Zhaoting Chen Xinying Jiang Jingcan Wu Lin Lin Zhengping Zhou Man Li Cheng Wang |
| author_sort | Zhaoting Chen |
| collection | DOAJ |
| description | Abstract Background It is unclear whether short-term blood pressure variability (BPV) is associated with target organ damage in patients with non-dialysis chronic kidney disease (CKD). Methods A cross-sectional, single-center study was conducted among 3442 non-dialysis CKD patients hospitalized in the department of Nephrology of the Fifth Affiliated Hospital of Sun Yat-sen University from November 2017 to July 2022 and collected the demographic, laboratory, clinic blood pressure, ambulatory blood pressure data, and short-term BPV assessed by the weighted standard deviation (wSD) derived from ambulatory blood pressure monitoring (ABPM). Multivariate logistic analyses were used to evaluate the independent effects between short-term BPV and subclinical target organ damage, including left ventricular hypertrophy (LVH), abnormal carotid intima-media thickness (CIMT), low estimated glomerular filtration rate (eGFR), and albuminuria. Results The average age of the participants was 47.53 ± 14.06 years and 56% of participants were male. The baseline eGFR was 69 mL/min/1.73 m2. Based on the tertile distribution of wSD according to equal numbers, patients were divided into three categories with T1(< 9.66 mmHg), T2(9.66–12.23 mmHg), and T3(> 12.23 mmHg) of SBPV; T1(< 8.17 mmHg), T2(8.17–9.93 mmHg), and T3(> 9.93 mmHg) of DBPV. The participants with the higher wSD group had a higher prevalence of target organ damage than their counterparts (P-trend < 0.05). An increasing trend in short-term variability was present with advancing CKD stages (P-trend < 0.001). Multivariate logistic analyses results showed that the odds ratio (OR) of SBP wSD was (1.07 [1.03,1.11], P < 0.001) for LVH, (1.04 [1.01,1.07, P = 0.029) for abnormal CIMT, (1.05 [1.02,1.08], P = 0.002) for low eGFR, and (1.06 [1.02,1.09], P = 0.002) for albuminuria; The OR of DBP wSD was (1.07 [1.02,1.12], P = 0.005) for LVH, (1.05 [1.01,1.09], P = 0.028) for abnormal CIMT, (1.05 [1.01,1.09], P = 0.022) for low eGFR, and (1.05 [1.01,1.10], P = 0.025) for albuminuria when adjusted for confounding factors and mean BP. Conclusions In conclusion, short-term BPV is associated with target organ damage, and irresponsible of average blood pressure levels, in Chinese non-dialysis CKD participants. |
| first_indexed | 2024-04-24T19:57:42Z |
| format | Article |
| id | doaj.art-0028dd1dcd8d4fb19ec7371c86c63614 |
| institution | Directory Open Access Journal |
| issn | 1471-2369 |
| language | English |
| last_indexed | 2024-04-24T19:57:42Z |
| publishDate | 2024-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Nephrology |
| spelling | doaj.art-0028dd1dcd8d4fb19ec7371c86c636142024-03-24T12:13:05ZengBMCBMC Nephrology1471-23692024-03-0125111110.1186/s12882-024-03541-xAssociation between short-term blood pressure variability and target organ damage in non-dialysis patients with chronic kidney diseaseZhaoting Chen0Xinying Jiang1Jingcan Wu2Lin Lin3Zhengping Zhou4Man Li5Cheng Wang6Division of Nephrology, Department of Medicine, The Fifth Affiliated Hospital Sun Yat-Sen UniversityDivision of Nephrology, Department of Medicine, The Fifth Affiliated Hospital Sun Yat-Sen UniversityDivision of Nephrology, Department of Medicine, The Fifth Affiliated Hospital Sun Yat-Sen UniversityDivision of Nephrology, Department of Medicine, The Fifth Affiliated Hospital Sun Yat-Sen UniversityDivision of Nephrology, Department of Medicine, The Fifth Affiliated Hospital Sun Yat-Sen UniversityGuangdong Provincial Key Laboratory of Biomedical Imaging, The Fifth Affiliated Hospital Sun Yat-Sen UniversityDivision of Nephrology, Department of Medicine, The Fifth Affiliated Hospital Sun Yat-Sen UniversityAbstract Background It is unclear whether short-term blood pressure variability (BPV) is associated with target organ damage in patients with non-dialysis chronic kidney disease (CKD). Methods A cross-sectional, single-center study was conducted among 3442 non-dialysis CKD patients hospitalized in the department of Nephrology of the Fifth Affiliated Hospital of Sun Yat-sen University from November 2017 to July 2022 and collected the demographic, laboratory, clinic blood pressure, ambulatory blood pressure data, and short-term BPV assessed by the weighted standard deviation (wSD) derived from ambulatory blood pressure monitoring (ABPM). Multivariate logistic analyses were used to evaluate the independent effects between short-term BPV and subclinical target organ damage, including left ventricular hypertrophy (LVH), abnormal carotid intima-media thickness (CIMT), low estimated glomerular filtration rate (eGFR), and albuminuria. Results The average age of the participants was 47.53 ± 14.06 years and 56% of participants were male. The baseline eGFR was 69 mL/min/1.73 m2. Based on the tertile distribution of wSD according to equal numbers, patients were divided into three categories with T1(< 9.66 mmHg), T2(9.66–12.23 mmHg), and T3(> 12.23 mmHg) of SBPV; T1(< 8.17 mmHg), T2(8.17–9.93 mmHg), and T3(> 9.93 mmHg) of DBPV. The participants with the higher wSD group had a higher prevalence of target organ damage than their counterparts (P-trend < 0.05). An increasing trend in short-term variability was present with advancing CKD stages (P-trend < 0.001). Multivariate logistic analyses results showed that the odds ratio (OR) of SBP wSD was (1.07 [1.03,1.11], P < 0.001) for LVH, (1.04 [1.01,1.07, P = 0.029) for abnormal CIMT, (1.05 [1.02,1.08], P = 0.002) for low eGFR, and (1.06 [1.02,1.09], P = 0.002) for albuminuria; The OR of DBP wSD was (1.07 [1.02,1.12], P = 0.005) for LVH, (1.05 [1.01,1.09], P = 0.028) for abnormal CIMT, (1.05 [1.01,1.09], P = 0.022) for low eGFR, and (1.05 [1.01,1.10], P = 0.025) for albuminuria when adjusted for confounding factors and mean BP. Conclusions In conclusion, short-term BPV is associated with target organ damage, and irresponsible of average blood pressure levels, in Chinese non-dialysis CKD participants.https://doi.org/10.1186/s12882-024-03541-xAmbulatory blood pressure monitoringBlood pressure variabilityWeighted standard deviationChronic kidney diseaseTarget organ damage |
| spellingShingle | Zhaoting Chen Xinying Jiang Jingcan Wu Lin Lin Zhengping Zhou Man Li Cheng Wang Association between short-term blood pressure variability and target organ damage in non-dialysis patients with chronic kidney disease BMC Nephrology Ambulatory blood pressure monitoring Blood pressure variability Weighted standard deviation Chronic kidney disease Target organ damage |
| title | Association between short-term blood pressure variability and target organ damage in non-dialysis patients with chronic kidney disease |
| title_full | Association between short-term blood pressure variability and target organ damage in non-dialysis patients with chronic kidney disease |
| title_fullStr | Association between short-term blood pressure variability and target organ damage in non-dialysis patients with chronic kidney disease |
| title_full_unstemmed | Association between short-term blood pressure variability and target organ damage in non-dialysis patients with chronic kidney disease |
| title_short | Association between short-term blood pressure variability and target organ damage in non-dialysis patients with chronic kidney disease |
| title_sort | association between short term blood pressure variability and target organ damage in non dialysis patients with chronic kidney disease |
| topic | Ambulatory blood pressure monitoring Blood pressure variability Weighted standard deviation Chronic kidney disease Target organ damage |
| url | https://doi.org/10.1186/s12882-024-03541-x |
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