Pan-Cancer Analysis Shows Enrichment of Macrophages, Overexpression of Checkpoint Molecules, Inhibitory Cytokines, and Immune Exhaustion Signatures in EMT-High Tumors

Pan-Cancer Analysis Shows Enrichment of Macrophages, Overexpression of Checkpoint Molecules, Inhibitory Cytokines, and Immune Exhaustion Signatures in EMT-High Tumors

Epithelial–mesenchymal transition (EMT) is a highly dynamic process that occurs under normal circumstances; however, EMT is also known to play a central role in tumor progression and metastasis. Furthermore, role of tumor immune microenvironment (TIME) in shaping anticancer immunity and inducing the...

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Bibliographic Details
Main Authors: Jayesh Kumar Tiwari, Shloka Negi, Manju Kashyap, Sheikh Nizamuddin, Amar Singh, Arun Khattri
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Oncology
Subjects:
epithelial–mesenchymal transition (EMT)
The Cancer Genome Atlas (TCGA)
tumor immune microenvironment (TIME)
immune checkpoints
cytokines
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.793881/full

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