The Clinical Significance of MicroRNAs in Colorectal Cancer Signaling Pathways: A Review
Colorectal carcinoma (colon and rectum) is currently considered among the most prevalent malignancies of Western societies. The pathogenesis and etiological mechanisms underlying colorectal cancer (CRC) development remain complex and heterogeneous. The homeostasis and function of normal human intest...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-12-01
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| Series: | Global Medical Genetics |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1777094 |
| _version_ | 1826994426027704320 |
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| author | Athanasios Michas Vasileios Michas Evangelos Anagnostou Michail Galanopoulos Maria Tolia Nikolaos Tsoukalas |
| author_facet | Athanasios Michas Vasileios Michas Evangelos Anagnostou Michail Galanopoulos Maria Tolia Nikolaos Tsoukalas |
| author_sort | Athanasios Michas |
| collection | DOAJ |
| description | Colorectal carcinoma (colon and rectum) is currently considered among the most prevalent malignancies of Western societies. The pathogenesis and etiological mechanisms underlying colorectal cancer (CRC) development remain complex and heterogeneous. The homeostasis and function of normal human intestinal cells is highly regulated by microRNAs. Therefore, it is not surprising that mutations and inactivation of these molecules appear to be linked with progression of colorectal tumors. Recent studies have reported significant alterations of microRNA expression in adenomas and CRCs compared with adjacent normal tissues. This observed deviation has been proposed to correlate with the progression and survival of disease as well as with choice of optimal treatment and drug resistance. MicroRNAs can adopt either oncogenic or tumor-suppressive roles during regulation of pathways that drive carcinogenesis. Typically, oncogenic microRNAs termed oncomirs, target and silence endogenous tumor-suppressor genes. On the other hand, tumor-suppressive microRNAs are critical in downregulating genes associated with cell growth and malignant capabilities. By extensively evaluating robust studies, we have emphasized and distinguished a discrete set of microRNAs that can modulate tumor progression by silencing specific driver genes crucial in signaling pathways including Wnt/b-catenin, epidermal growth factor receptor, P53, mismatch repair DNA repair, and transforming-growth factor beta. |
| first_indexed | 2024-03-10T05:20:20Z |
| format | Article |
| id | doaj.art-002ba2b503c440dc8e42daf5a598b46c |
| institution | Directory Open Access Journal |
| issn | 2699-9404 |
| language | English |
| last_indexed | 2025-02-18T09:18:29Z |
| publishDate | 2023-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Global Medical Genetics |
| spelling | doaj.art-002ba2b503c440dc8e42daf5a598b46c2024-11-02T22:03:06ZengKeAi Communications Co., Ltd.Global Medical Genetics2699-94042023-12-01100431532310.1055/s-0043-1777094The Clinical Significance of MicroRNAs in Colorectal Cancer Signaling Pathways: A ReviewAthanasios Michas0Vasileios Michas1Evangelos Anagnostou2Michail Galanopoulos3Maria Tolia4Nikolaos Tsoukalas5Department of Oncology, 401 General Military Hospital of Athens, Athens, GreeceDepartment of Radiology, Achepa General Hospital Thessaloniki, Thessaloniki, GreeceDepartment of Neurosurgery, Queen Elizabeth Hospital Birmingham, Birmingham, United KingdomDepartment of Oncology, 401 General Military Hospital of Athens, Athens, GreeceDepartment of Oncology, 401 General Military Hospital of Athens, Athens, GreeceDepartment of Oncology, 401 General Military Hospital of Athens, Athens, GreeceColorectal carcinoma (colon and rectum) is currently considered among the most prevalent malignancies of Western societies. The pathogenesis and etiological mechanisms underlying colorectal cancer (CRC) development remain complex and heterogeneous. The homeostasis and function of normal human intestinal cells is highly regulated by microRNAs. Therefore, it is not surprising that mutations and inactivation of these molecules appear to be linked with progression of colorectal tumors. Recent studies have reported significant alterations of microRNA expression in adenomas and CRCs compared with adjacent normal tissues. This observed deviation has been proposed to correlate with the progression and survival of disease as well as with choice of optimal treatment and drug resistance. MicroRNAs can adopt either oncogenic or tumor-suppressive roles during regulation of pathways that drive carcinogenesis. Typically, oncogenic microRNAs termed oncomirs, target and silence endogenous tumor-suppressor genes. On the other hand, tumor-suppressive microRNAs are critical in downregulating genes associated with cell growth and malignant capabilities. By extensively evaluating robust studies, we have emphasized and distinguished a discrete set of microRNAs that can modulate tumor progression by silencing specific driver genes crucial in signaling pathways including Wnt/b-catenin, epidermal growth factor receptor, P53, mismatch repair DNA repair, and transforming-growth factor beta.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1777094microRNAsgenomicscolorectal cancermolecular pathways |
| spellingShingle | Athanasios Michas Vasileios Michas Evangelos Anagnostou Michail Galanopoulos Maria Tolia Nikolaos Tsoukalas The Clinical Significance of MicroRNAs in Colorectal Cancer Signaling Pathways: A Review Global Medical Genetics microRNAs genomics colorectal cancer molecular pathways |
| title | The Clinical Significance of MicroRNAs in Colorectal Cancer Signaling Pathways: A Review |
| title_full | The Clinical Significance of MicroRNAs in Colorectal Cancer Signaling Pathways: A Review |
| title_fullStr | The Clinical Significance of MicroRNAs in Colorectal Cancer Signaling Pathways: A Review |
| title_full_unstemmed | The Clinical Significance of MicroRNAs in Colorectal Cancer Signaling Pathways: A Review |
| title_short | The Clinical Significance of MicroRNAs in Colorectal Cancer Signaling Pathways: A Review |
| title_sort | clinical significance of micrornas in colorectal cancer signaling pathways a review |
| topic | microRNAs genomics colorectal cancer molecular pathways |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0043-1777094 |
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