Measurement of human abdominal and femoral intravascular adipose tissue blood flow using percutaneous Doppler ultrasound
Adipose tissue blood flow (ATBF) is an important determinant of adipose tissue (AT) function. 133Xenon wash-out technique is considered the gold-standard for human ATBF measurements. However, decreasing 133Xenon clinical use and costly production and preservation, make alternative (non-invasive) met...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | Adipocyte |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/21623945.2021.1888471 |
| _version_ | 1818966872640454656 |
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| author | Ioannis G. Lempesis Gijs H. Goossens Konstantinos N. Manolopoulos |
| author_facet | Ioannis G. Lempesis Gijs H. Goossens Konstantinos N. Manolopoulos |
| author_sort | Ioannis G. Lempesis |
| collection | DOAJ |
| description | Adipose tissue blood flow (ATBF) is an important determinant of adipose tissue (AT) function. 133Xenon wash-out technique is considered the gold-standard for human ATBF measurements. However, decreasing 133Xenon clinical use and costly production and preservation, make alternative (non-invasive) methods necessary. Here, we explored percutaneous Doppler ultrasound as a proxy method to quantify intravascular subcutaneous abdominal and femoral ATBF in humans (n= 17). Both fasting ATBF and the postprandial increase in ATBF were significantly higher in abdominal compared to femoral AT. Although anatomical variations in vein location and depot thickness may impact feasibility, we demonstrate that Doppler ultrasound detects the expected depot-differences and postprandial increase in ATBF in healthy individuals. This method warrants further investigation in other populations and metabolic conditions. |
| first_indexed | 2024-12-20T13:39:48Z |
| format | Article |
| id | doaj.art-002d9f7b7a36478d9feadc4fff464350 |
| institution | Directory Open Access Journal |
| issn | 2162-3945 2162-397X |
| language | English |
| last_indexed | 2024-12-20T13:39:48Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Adipocyte |
| spelling | doaj.art-002d9f7b7a36478d9feadc4fff4643502022-12-21T19:38:50ZengTaylor & Francis GroupAdipocyte2162-39452162-397X2021-01-0110111912310.1080/21623945.2021.18884711888471Measurement of human abdominal and femoral intravascular adipose tissue blood flow using percutaneous Doppler ultrasoundIoannis G. Lempesis0Gijs H. Goossens1Konstantinos N. Manolopoulos2Institute of Metabolism and Systems Research (IMSR), College of Medical and Dental Sciences, University of BirminghamMaastricht University Medical Centre+Institute of Metabolism and Systems Research (IMSR), College of Medical and Dental Sciences, University of BirminghamAdipose tissue blood flow (ATBF) is an important determinant of adipose tissue (AT) function. 133Xenon wash-out technique is considered the gold-standard for human ATBF measurements. However, decreasing 133Xenon clinical use and costly production and preservation, make alternative (non-invasive) methods necessary. Here, we explored percutaneous Doppler ultrasound as a proxy method to quantify intravascular subcutaneous abdominal and femoral ATBF in humans (n= 17). Both fasting ATBF and the postprandial increase in ATBF were significantly higher in abdominal compared to femoral AT. Although anatomical variations in vein location and depot thickness may impact feasibility, we demonstrate that Doppler ultrasound detects the expected depot-differences and postprandial increase in ATBF in healthy individuals. This method warrants further investigation in other populations and metabolic conditions.http://dx.doi.org/10.1080/21623945.2021.1888471adipose tissuefat depotsblood flowdoppler ultrasoundhuman physiology |
| spellingShingle | Ioannis G. Lempesis Gijs H. Goossens Konstantinos N. Manolopoulos Measurement of human abdominal and femoral intravascular adipose tissue blood flow using percutaneous Doppler ultrasound Adipocyte adipose tissue fat depots blood flow doppler ultrasound human physiology |
| title | Measurement of human abdominal and femoral intravascular adipose tissue blood flow using percutaneous Doppler ultrasound |
| title_full | Measurement of human abdominal and femoral intravascular adipose tissue blood flow using percutaneous Doppler ultrasound |
| title_fullStr | Measurement of human abdominal and femoral intravascular adipose tissue blood flow using percutaneous Doppler ultrasound |
| title_full_unstemmed | Measurement of human abdominal and femoral intravascular adipose tissue blood flow using percutaneous Doppler ultrasound |
| title_short | Measurement of human abdominal and femoral intravascular adipose tissue blood flow using percutaneous Doppler ultrasound |
| title_sort | measurement of human abdominal and femoral intravascular adipose tissue blood flow using percutaneous doppler ultrasound |
| topic | adipose tissue fat depots blood flow doppler ultrasound human physiology |
| url | http://dx.doi.org/10.1080/21623945.2021.1888471 |
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