Repurposing Cancer Drugs Batimastat and Marimastat to Inhibit the Activity of a Group I Metalloprotease from the Venom of the Western Diamondback Rattlesnake, <i>Crotalus atrox</i>

Repurposing Cancer Drugs Batimastat and Marimastat to Inhibit the Activity of a Group I Metalloprotease from the Venom of the Western Diamondback Rattlesnake, <i>Crotalus atrox</i>

Snakebite envenomation causes over 140,000 deaths every year, predominantly in developing countries. As a result, it is one of the most lethal neglected tropical diseases. It is associated with incredibly complex pathophysiology due to the vast number of unique toxins/proteins present in the venoms...

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Bibliographic Details
Main Authors: Harry J. Layfield, Harry F. Williams, Divyashree Ravishankar, Amita Mehmi, Medha Sonavane, Anika Salim, Rajendran Vaiyapuri, Karthik Lakshminarayanan, Thomas M. Vallance, Andrew B. Bicknell, Steven A. Trim, Ketan Patel, Sakthivel Vaiyapuri
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Toxins
Subjects:
<i>Crotalus atrox</i>
metalloprotease
snake venom
neglected tropical disease
rattlesnake
batimastat
Online Access:https://www.mdpi.com/2072-6651/12/5/309

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