Contribution of concomitant myocarditis to the development of various clinical types of arrhythmogenic right ventricular cardiomyopathy
Aim. To assess the contribution of genetic and inflammatory factors to the development of arrhythmogenic right ventricular cardiomyopathy (ARVC).Material and methods. The study involved 54 patients with ARVC (age, 38,7±14,1 years; men, 42,6%; mean follow-up period, 21 [6; 60] months). All patients u...
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| Format: | Article |
| Language: | Russian |
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«SILICEA-POLIGRAF» LLC
2021-09-01
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| Series: | Кардиоваскулярная терапия и профилактика |
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| Online Access: | https://cardiovascular.elpub.ru/jour/article/view/2781 |
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| author | Yu. A. Lutokhina O. V. Blagova A. V. Nedostup S. A. Alexandrova E. V. Evseeva A. G Shestak E. V. Zaklyazminskaya |
| author_facet | Yu. A. Lutokhina O. V. Blagova A. V. Nedostup S. A. Alexandrova E. V. Evseeva A. G Shestak E. V. Zaklyazminskaya |
| author_sort | Yu. A. Lutokhina |
| collection | DOAJ |
| description | Aim. To assess the contribution of genetic and inflammatory factors to the development of arrhythmogenic right ventricular cardiomyopathy (ARVC).Material and methods. The study involved 54 patients with ARVC (age, 38,7±14,1 years; men, 42,6%; mean follow-up period, 21 [6; 60] months). All patients underwent electrocardiography (ECG), 24-hour ECG monitoring, echocardiography, determination of anticardiac antibodies and DNA of cardiotropic viruses in the blood, molecular genetic ARVC testing, as well as cardiac magnetic resonance imaging (n=49), high-resolution ECG (n=18), right ventricular endomyocardial biopsy (n=2), and autopsy (n=2).Results. Following four clinical types of ARVC were identified: I. Latent arrhythmic form: characterized by frequent premature ventricular contractions and/or nonsustained ventricular tachycardia (VT). II. Manifested arrhythmic form (n=11) — SVT/ventricular fibrillation (VF). III. ARVC with progressive heart failure (HF, n=8). IV. Combination of ARVC with left ventricular noncompaction (LVNC, n=8). Superimposed myocarditis was identified in 74%, 36%, 87,5% and 85,7% of patients in forms I-IV, respectively. Mutations were detected in 11%, 46%, 50%, and 38% of patients in forms I-IV, respectively. Clinical forms were stable: there was no transition from one clinical form to another during follow-up period.Conclusion. The contribution of genetic and inflammatory mechanisms to the clinical picture is different: in the latent arrhythmic form, the leading role belongs to inflammation; in the manifested arrhythmic form, the contribution of pathogenic mutations prevails, and in ARVC with progressive HF and in combination with LVNC, the contribution of genetic and inflammatory factors is equally important. |
| first_indexed | 2024-04-10T03:33:37Z |
| format | Article |
| id | doaj.art-00331668a1854c5cbbc5befad908a933 |
| institution | Directory Open Access Journal |
| issn | 1728-8800 2619-0125 |
| language | Russian |
| last_indexed | 2024-04-10T03:33:37Z |
| publishDate | 2021-09-01 |
| publisher | «SILICEA-POLIGRAF» LLC |
| record_format | Article |
| series | Кардиоваскулярная терапия и профилактика |
| spelling | doaj.art-00331668a1854c5cbbc5befad908a9332023-03-13T07:23:30Zrus«SILICEA-POLIGRAF» LLCКардиоваскулярная терапия и профилактика1728-88002619-01252021-09-0120510.15829/1728-8800-2021-27812284Contribution of concomitant myocarditis to the development of various clinical types of arrhythmogenic right ventricular cardiomyopathyYu. A. Lutokhina0O. V. Blagova1A. V. Nedostup2S. A. Alexandrova3E. V. Evseeva4A. G Shestak5E. V. Zaklyazminskaya6Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет)Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет)Первый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет)Национальный медицинский исследовательский центр сердечно-сосудистой хирургии им. А.Н. Бакулева Минздрава РоссииПервый МГМУ им. И.М. Сеченова Минздрава России (Сеченовский Университет)Российский научный центр хирургии им. акад. Б.В. ПетровскогоРоссийский научный центр хирургии им. акад. Б.В. ПетровскогоAim. To assess the contribution of genetic and inflammatory factors to the development of arrhythmogenic right ventricular cardiomyopathy (ARVC).Material and methods. The study involved 54 patients with ARVC (age, 38,7±14,1 years; men, 42,6%; mean follow-up period, 21 [6; 60] months). All patients underwent electrocardiography (ECG), 24-hour ECG monitoring, echocardiography, determination of anticardiac antibodies and DNA of cardiotropic viruses in the blood, molecular genetic ARVC testing, as well as cardiac magnetic resonance imaging (n=49), high-resolution ECG (n=18), right ventricular endomyocardial biopsy (n=2), and autopsy (n=2).Results. Following four clinical types of ARVC were identified: I. Latent arrhythmic form: characterized by frequent premature ventricular contractions and/or nonsustained ventricular tachycardia (VT). II. Manifested arrhythmic form (n=11) — SVT/ventricular fibrillation (VF). III. ARVC with progressive heart failure (HF, n=8). IV. Combination of ARVC with left ventricular noncompaction (LVNC, n=8). Superimposed myocarditis was identified in 74%, 36%, 87,5% and 85,7% of patients in forms I-IV, respectively. Mutations were detected in 11%, 46%, 50%, and 38% of patients in forms I-IV, respectively. Clinical forms were stable: there was no transition from one clinical form to another during follow-up period.Conclusion. The contribution of genetic and inflammatory mechanisms to the clinical picture is different: in the latent arrhythmic form, the leading role belongs to inflammation; in the manifested arrhythmic form, the contribution of pathogenic mutations prevails, and in ARVC with progressive HF and in combination with LVNC, the contribution of genetic and inflammatory factors is equally important.https://cardiovascular.elpub.ru/jour/article/view/2781аритмогенная дисплазия/кардиомиопатия правого желудочкажелудочковая экстрасистолияжелудочковая тахикардиямиокардитхроническая сердечная недостаточностьнекомпактный миокард |
| spellingShingle | Yu. A. Lutokhina O. V. Blagova A. V. Nedostup S. A. Alexandrova E. V. Evseeva A. G Shestak E. V. Zaklyazminskaya Contribution of concomitant myocarditis to the development of various clinical types of arrhythmogenic right ventricular cardiomyopathy Кардиоваскулярная терапия и профилактика аритмогенная дисплазия/кардиомиопатия правого желудочка желудочковая экстрасистолия желудочковая тахикардия миокардит хроническая сердечная недостаточность некомпактный миокард |
| title | Contribution of concomitant myocarditis to the development of various clinical types of arrhythmogenic right ventricular cardiomyopathy |
| title_full | Contribution of concomitant myocarditis to the development of various clinical types of arrhythmogenic right ventricular cardiomyopathy |
| title_fullStr | Contribution of concomitant myocarditis to the development of various clinical types of arrhythmogenic right ventricular cardiomyopathy |
| title_full_unstemmed | Contribution of concomitant myocarditis to the development of various clinical types of arrhythmogenic right ventricular cardiomyopathy |
| title_short | Contribution of concomitant myocarditis to the development of various clinical types of arrhythmogenic right ventricular cardiomyopathy |
| title_sort | contribution of concomitant myocarditis to the development of various clinical types of arrhythmogenic right ventricular cardiomyopathy |
| topic | аритмогенная дисплазия/кардиомиопатия правого желудочка желудочковая экстрасистолия желудочковая тахикардия миокардит хроническая сердечная недостаточность некомпактный миокард |
| url | https://cardiovascular.elpub.ru/jour/article/view/2781 |
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