Extramedullary plasmacytoma of the oral cavity metastasising to both kidneys in a dog
Abstract Background Most extramedullary plasmacytomas (EMPs) aresolitary and located in the head and neck region. They may also occur in the visceral parts of the body. Objectives Here, we report a case of oral EMP followed by neoplastic plasma cell metastasis to both kidneys in a neutered male Pome...
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-05-01
|
| Series: | Veterinary Medicine and Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/vms3.1086 |
| _version_ | 1797825853978050560 |
|---|---|
| author | Kyung Ho Park Tae‐Un Kim Hyun‐Woo Park Seoung‐Woo Lee Su‐Min Baek Daji Noh Jae‐Hyuk Yim Young‐Jin Lee Yeon‐Gyeong Kim Dong‐Ju Son Sang‐Joon Park Seong‐Kyoon Choi Kija Lee Larry Chong Park Jin‐Kyu Park |
| author_facet | Kyung Ho Park Tae‐Un Kim Hyun‐Woo Park Seoung‐Woo Lee Su‐Min Baek Daji Noh Jae‐Hyuk Yim Young‐Jin Lee Yeon‐Gyeong Kim Dong‐Ju Son Sang‐Joon Park Seong‐Kyoon Choi Kija Lee Larry Chong Park Jin‐Kyu Park |
| author_sort | Kyung Ho Park |
| collection | DOAJ |
| description | Abstract Background Most extramedullary plasmacytomas (EMPs) aresolitary and located in the head and neck region. They may also occur in the visceral parts of the body. Objectives Here, we report a case of oral EMP followed by neoplastic plasma cell metastasis to both kidneys in a neutered male Pomeranian. Methods Oral plasmacytoma recurred 11 months aftersurgical removal of an oral mass and partial maxillectomy was performed. Eighteen months after partial maxillectomy, neoplastic masses were detected in both kidneys on computed tomography. The dog died 12 months after detection of bilateral kidney neoplasms. The resected neoplastic masses were routinely processed for histopathological observation and immunohistochemistry against pan‐cytokeratin, desmin, CD3, and MUM‐1. Results The recurred mass mainly consisted of well‐differentiated plasma cells and contained a small portion of aggressive cells with malignant features. Monoclonal gammopathy was not observed on serumelectrophoresis performed to exclude multiple myeloma. The mass was composed of plasma cells with high nuclear pleomorphism and abundant mitotic figures. The neoplasm stained positive for MUM‐1 with a more aggressive morphology than in oral EMP. Conclusion Based on serum biomarker and pathological observations, a diagnosis of recurrence and metastasis of oral‐to‐renal EMP was established. To the best of our knowledge, metastasis of oral EMP into the bilateral kidneys, as described in the current case, has not been previously reported in dogs. |
| first_indexed | 2024-03-13T10:59:02Z |
| format | Article |
| id | doaj.art-003485cb8acc4e7ebb44eeefb021e220 |
| institution | Directory Open Access Journal |
| issn | 2053-1095 |
| language | English |
| last_indexed | 2024-03-13T10:59:02Z |
| publishDate | 2023-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Veterinary Medicine and Science |
| spelling | doaj.art-003485cb8acc4e7ebb44eeefb021e2202023-05-16T19:51:19ZengWileyVeterinary Medicine and Science2053-10952023-05-01931053106110.1002/vms3.1086Extramedullary plasmacytoma of the oral cavity metastasising to both kidneys in a dogKyung Ho Park0Tae‐Un Kim1Hyun‐Woo Park2Seoung‐Woo Lee3Su‐Min Baek4Daji Noh5Jae‐Hyuk Yim6Young‐Jin Lee7Yeon‐Gyeong Kim8Dong‐Ju Son9Sang‐Joon Park10Seong‐Kyoon Choi11Kija Lee12Larry Chong Park13Jin‐Kyu Park14Department of Veterinary Pathology College of Veterinary Medicine Kyungpook National University Daegu Republic of KoreaDepartment of Veterinary Pathology College of Veterinary Medicine Kyungpook National University Daegu Republic of KoreaNaason Science, Inc. CheongjuRepublic of KoreaDepartment of Veterinary Pathology College of Veterinary Medicine Kyungpook National University Daegu Republic of KoreaDepartment of Veterinary Pathology College of Veterinary Medicine Kyungpook National University Daegu Republic of Korea24 Africa Animal Medical Center Daejeon Republic of KoreaDepartment of Veterinary Pathology College of Veterinary Medicine Kyungpook National University Daegu Republic of KoreaDepartment of Veterinary Pathology College of Veterinary Medicine Kyungpook National University Daegu Republic of KoreaNaason Science, Inc. CheongjuRepublic of KoreaDepartment of Veterinary Internal Medicine College of Veterinary Medicine, Kyungpook National University Daegu Republic of KoreaLaboratory of Veterinary Histology, College of Veterinary Medicine Kyungpook National University Daegu Republic of KoreaCore Protein Resources Center (CPRC) Division of Biotechnology, DGIST Daegu Republic of KoreaDepartment of Veterinary Medical Imaging, College of Veterinary Medicine Kyungpook National University Daegu Republic of KoreaNaason Science, Inc. CheongjuRepublic of KoreaDepartment of Veterinary Pathology College of Veterinary Medicine Kyungpook National University Daegu Republic of KoreaAbstract Background Most extramedullary plasmacytomas (EMPs) aresolitary and located in the head and neck region. They may also occur in the visceral parts of the body. Objectives Here, we report a case of oral EMP followed by neoplastic plasma cell metastasis to both kidneys in a neutered male Pomeranian. Methods Oral plasmacytoma recurred 11 months aftersurgical removal of an oral mass and partial maxillectomy was performed. Eighteen months after partial maxillectomy, neoplastic masses were detected in both kidneys on computed tomography. The dog died 12 months after detection of bilateral kidney neoplasms. The resected neoplastic masses were routinely processed for histopathological observation and immunohistochemistry against pan‐cytokeratin, desmin, CD3, and MUM‐1. Results The recurred mass mainly consisted of well‐differentiated plasma cells and contained a small portion of aggressive cells with malignant features. Monoclonal gammopathy was not observed on serumelectrophoresis performed to exclude multiple myeloma. The mass was composed of plasma cells with high nuclear pleomorphism and abundant mitotic figures. The neoplasm stained positive for MUM‐1 with a more aggressive morphology than in oral EMP. Conclusion Based on serum biomarker and pathological observations, a diagnosis of recurrence and metastasis of oral‐to‐renal EMP was established. To the best of our knowledge, metastasis of oral EMP into the bilateral kidneys, as described in the current case, has not been previously reported in dogs.https://doi.org/10.1002/vms3.1086dogextramedullary plasmacytomakidneymetastasisrecurrence |
| spellingShingle | Kyung Ho Park Tae‐Un Kim Hyun‐Woo Park Seoung‐Woo Lee Su‐Min Baek Daji Noh Jae‐Hyuk Yim Young‐Jin Lee Yeon‐Gyeong Kim Dong‐Ju Son Sang‐Joon Park Seong‐Kyoon Choi Kija Lee Larry Chong Park Jin‐Kyu Park Extramedullary plasmacytoma of the oral cavity metastasising to both kidneys in a dog Veterinary Medicine and Science dog extramedullary plasmacytoma kidney metastasis recurrence |
| title | Extramedullary plasmacytoma of the oral cavity metastasising to both kidneys in a dog |
| title_full | Extramedullary plasmacytoma of the oral cavity metastasising to both kidneys in a dog |
| title_fullStr | Extramedullary plasmacytoma of the oral cavity metastasising to both kidneys in a dog |
| title_full_unstemmed | Extramedullary plasmacytoma of the oral cavity metastasising to both kidneys in a dog |
| title_short | Extramedullary plasmacytoma of the oral cavity metastasising to both kidneys in a dog |
| title_sort | extramedullary plasmacytoma of the oral cavity metastasising to both kidneys in a dog |
| topic | dog extramedullary plasmacytoma kidney metastasis recurrence |
| url | https://doi.org/10.1002/vms3.1086 |
| work_keys_str_mv | AT kyunghopark extramedullaryplasmacytomaoftheoralcavitymetastasisingtobothkidneysinadog AT taeunkim extramedullaryplasmacytomaoftheoralcavitymetastasisingtobothkidneysinadog AT hyunwoopark extramedullaryplasmacytomaoftheoralcavitymetastasisingtobothkidneysinadog AT seoungwoolee extramedullaryplasmacytomaoftheoralcavitymetastasisingtobothkidneysinadog AT suminbaek extramedullaryplasmacytomaoftheoralcavitymetastasisingtobothkidneysinadog AT dajinoh extramedullaryplasmacytomaoftheoralcavitymetastasisingtobothkidneysinadog AT jaehyukyim extramedullaryplasmacytomaoftheoralcavitymetastasisingtobothkidneysinadog AT youngjinlee extramedullaryplasmacytomaoftheoralcavitymetastasisingtobothkidneysinadog AT yeongyeongkim extramedullaryplasmacytomaoftheoralcavitymetastasisingtobothkidneysinadog AT dongjuson extramedullaryplasmacytomaoftheoralcavitymetastasisingtobothkidneysinadog AT sangjoonpark extramedullaryplasmacytomaoftheoralcavitymetastasisingtobothkidneysinadog AT seongkyoonchoi extramedullaryplasmacytomaoftheoralcavitymetastasisingtobothkidneysinadog AT kijalee extramedullaryplasmacytomaoftheoralcavitymetastasisingtobothkidneysinadog AT larrychongpark extramedullaryplasmacytomaoftheoralcavitymetastasisingtobothkidneysinadog AT jinkyupark extramedullaryplasmacytomaoftheoralcavitymetastasisingtobothkidneysinadog |