The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat.
Herpes simplex encephalitis (HSE) is a fatal infection of the central nervous system (CNS) predominantly caused by Herpes simplex virus type 1. Factors regulating the susceptibility to HSE are still largely unknown. To identify host gene(s) regulating HSE susceptibility we performed a genome-wide li...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2012-01-01
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| Series: | PLoS Pathogens |
| Online Access: | http://europepmc.org/articles/PMC3386237?pdf=render |
| _version_ | 1818908316628156416 |
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| author | Nada Abdelmagid Biborka Bereczky-Veress André Ortlieb Guerreiro-Cacais Petra Bergman Katarina M Luhr Tomas Bergström Birgit Sköldenberg Fredrik Piehl Tomas Olsson Margarita Diez |
| author_facet | Nada Abdelmagid Biborka Bereczky-Veress André Ortlieb Guerreiro-Cacais Petra Bergman Katarina M Luhr Tomas Bergström Birgit Sköldenberg Fredrik Piehl Tomas Olsson Margarita Diez |
| author_sort | Nada Abdelmagid |
| collection | DOAJ |
| description | Herpes simplex encephalitis (HSE) is a fatal infection of the central nervous system (CNS) predominantly caused by Herpes simplex virus type 1. Factors regulating the susceptibility to HSE are still largely unknown. To identify host gene(s) regulating HSE susceptibility we performed a genome-wide linkage scan in an intercross between the susceptible DA and the resistant PVG rat. We found one major quantitative trait locus (QTL), Hse1, on rat chromosome 4 (confidence interval 24.3-31 Mb; LOD score 29.5) governing disease susceptibility. Fine mapping of Hse1 using recombinants, haplotype mapping and sequencing, as well as expression analysis of all genes in the interval identified the calcitonin receptor gene (Calcr) as the main candidate, which also is supported by functional studies. Thus, using unbiased genetic approach variability in Calcr was identified as potentially critical for infection and viral spread to the CNS and subsequent HSE development. |
| first_indexed | 2024-12-19T22:09:05Z |
| format | Article |
| id | doaj.art-00349c928f224e4c83d88e5a63ee02a6 |
| institution | Directory Open Access Journal |
| issn | 1553-7366 1553-7374 |
| language | English |
| last_indexed | 2024-12-19T22:09:05Z |
| publishDate | 2012-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Pathogens |
| spelling | doaj.art-00349c928f224e4c83d88e5a63ee02a62022-12-21T20:03:57ZengPublic Library of Science (PLoS)PLoS Pathogens1553-73661553-73742012-01-0186e100275310.1371/journal.ppat.1002753The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat.Nada AbdelmagidBiborka Bereczky-VeressAndré Ortlieb Guerreiro-CacaisPetra BergmanKatarina M LuhrTomas BergströmBirgit SköldenbergFredrik PiehlTomas OlssonMargarita DiezHerpes simplex encephalitis (HSE) is a fatal infection of the central nervous system (CNS) predominantly caused by Herpes simplex virus type 1. Factors regulating the susceptibility to HSE are still largely unknown. To identify host gene(s) regulating HSE susceptibility we performed a genome-wide linkage scan in an intercross between the susceptible DA and the resistant PVG rat. We found one major quantitative trait locus (QTL), Hse1, on rat chromosome 4 (confidence interval 24.3-31 Mb; LOD score 29.5) governing disease susceptibility. Fine mapping of Hse1 using recombinants, haplotype mapping and sequencing, as well as expression analysis of all genes in the interval identified the calcitonin receptor gene (Calcr) as the main candidate, which also is supported by functional studies. Thus, using unbiased genetic approach variability in Calcr was identified as potentially critical for infection and viral spread to the CNS and subsequent HSE development.http://europepmc.org/articles/PMC3386237?pdf=render |
| spellingShingle | Nada Abdelmagid Biborka Bereczky-Veress André Ortlieb Guerreiro-Cacais Petra Bergman Katarina M Luhr Tomas Bergström Birgit Sköldenberg Fredrik Piehl Tomas Olsson Margarita Diez The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat. PLoS Pathogens |
| title | The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat. |
| title_full | The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat. |
| title_fullStr | The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat. |
| title_full_unstemmed | The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat. |
| title_short | The calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat. |
| title_sort | calcitonin receptor gene is a candidate for regulation of susceptibility to herpes simplex type 1 neuronal infection leading to encephalitis in rat |
| url | http://europepmc.org/articles/PMC3386237?pdf=render |
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