High cerebrospinal fluid lactate concentration at 48 h of hospital admission predicts poor outcomes in patients with tuberculous meningitis: A multicenter retrospective cohort study
ObjectiveThis study aimed to analyze the cerebrospinal fluid (CSF) parameters affecting the outcomes of patients with tuberculous meningitis (TBM).MethodsThis is a multi-center, retrospective, cohort study involving 81 patients who were diagnosed with TBM and treated in Haihe Clinical College of Tia...
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2022.989832/full |
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| author | Chenchao Liu Chenchao Liu Chenchao Liu Chenchao Liu Ruixue Huai Yijia Xiang Yijia Xiang Xu Han Xu Han Zixiang Chen Zixiang Chen Yuhan Liu Xingjun Liu Xingjun Liu Huiquan Liu Huiquan Liu Hong Zhang Hong Zhang Sihan Wang Sihan Wang Lingyu Hao Lingyu Hao Yin Bo Yin Bo Yuanbo Luo Yuanbo Luo Yiyi Wang Yiyi Wang Yi Wang Yi Wang |
| author_facet | Chenchao Liu Chenchao Liu Chenchao Liu Chenchao Liu Ruixue Huai Yijia Xiang Yijia Xiang Xu Han Xu Han Zixiang Chen Zixiang Chen Yuhan Liu Xingjun Liu Xingjun Liu Huiquan Liu Huiquan Liu Hong Zhang Hong Zhang Sihan Wang Sihan Wang Lingyu Hao Lingyu Hao Yin Bo Yin Bo Yuanbo Luo Yuanbo Luo Yiyi Wang Yiyi Wang Yi Wang Yi Wang |
| author_sort | Chenchao Liu |
| collection | DOAJ |
| description | ObjectiveThis study aimed to analyze the cerebrospinal fluid (CSF) parameters affecting the outcomes of patients with tuberculous meningitis (TBM).MethodsThis is a multi-center, retrospective, cohort study involving 81 patients who were diagnosed with TBM and treated in Haihe Clinical College of Tianjin Medical University, Tianjin Medical University General Hospital, and General Hospital of Air Force PLA from January 2016 to December 2019. Baseline data, Glasgow Coma Scale (GCS) score, and clinical presentations of all patients were collected at admission. CSF samples were collected at 48 h, 1, 2, and 3 weeks after admission. CSF lactate, adenosine deaminase, chloride, protein, glucose levels and intracranial pressure were measured. After a follow-up of 16.14 ± 3.03 months, all patients were assessed using the modified Rankin Scale (mRS) and divided into good (mRS scores of 0–2 points) and poor outcome groups (mRS scores of 3–6 points). The differences in patients' baseline data, GCS score, clinical presentations, and levels of CSF parameters detected at 48 h, 1, 2, and 3 weeks after admission between two groups were compared. Statistically significant variables were added to the binary logistic regression model to identify the factors impacting the outcomes of patients with TBM. Receiver operating characteristic (ROC) curve was used to assess the predictive ability of the model.ResultsThe CSF lactate level exhibited a decreasing trend within 3 weeks of admission in the two groups. For the within-group comparison, statistically significant differences in the lactate level was found in both groups between four different time points. A binary logistic regression model revealed that CSF lactate level at 48 h after admission, age, and GSC score on admission were independently associated with the outcomes of patients with TBM. ROC curve analysis showed that the area under the ROC curve (AUC) was 0.786 for the CSF lactate level (48 h), 0.814 for GCS score, and 0.764 for age.ConclusionHigh CSF lactate level at 48 h after admission is one of the important factors for poor outcomes in patients with TBM. |
| first_indexed | 2024-04-12T09:58:10Z |
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| id | doaj.art-0034a795be394370ba488a7f9e2072d2 |
| institution | Directory Open Access Journal |
| issn | 1664-2295 |
| language | English |
| last_indexed | 2024-04-12T09:58:10Z |
| publishDate | 2022-10-01 |
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| series | Frontiers in Neurology |
| spelling | doaj.art-0034a795be394370ba488a7f9e2072d22022-12-22T03:37:37ZengFrontiers Media S.A.Frontiers in Neurology1664-22952022-10-011310.3389/fneur.2022.989832989832High cerebrospinal fluid lactate concentration at 48 h of hospital admission predicts poor outcomes in patients with tuberculous meningitis: A multicenter retrospective cohort studyChenchao Liu0Chenchao Liu1Chenchao Liu2Chenchao Liu3Ruixue Huai4Yijia Xiang5Yijia Xiang6Xu Han7Xu Han8Zixiang Chen9Zixiang Chen10Yuhan Liu11Xingjun Liu12Xingjun Liu13Huiquan Liu14Huiquan Liu15Hong Zhang16Hong Zhang17Sihan Wang18Sihan Wang19Lingyu Hao20Lingyu Hao21Yin Bo22Yin Bo23Yuanbo Luo24Yuanbo Luo25Yiyi Wang26Yiyi Wang27Yi Wang28Yi Wang29Department of Neurology, Haihe Clinical School, Tianjin Medical University, Tianjin, ChinaTCM Key Research Laboratory for Infectious Disease Prevention for State Administration of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, ChinaKey Laboratory of Post-trauma Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education and Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin Neurological Institute, Tianjin, ChinaDepartment of Neurology, Tianjin Jinnan Hospital, Tianjin, ChinaDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, ChinaKey Laboratory of Post-trauma Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education and Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin Neurological Institute, Tianjin, ChinaDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, ChinaKey Laboratory of Post-trauma Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education and Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin Neurological Institute, Tianjin, ChinaDepartment of Neurology, Haihe Clinical School, Tianjin Medical University, Tianjin, ChinaTCM Key Research Laboratory for Infectious Disease Prevention for State Administration of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Neurosurgery, People's Liberation Army Air Force Medical Center, Beijing, ChinaDepartment of Neurology, Haihe Clinical School, Tianjin Medical University, Tianjin, ChinaTCM Key Research Laboratory for Infectious Disease Prevention for State Administration of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Neurology, Haihe Clinical School, Tianjin Medical University, Tianjin, ChinaTCM Key Research Laboratory for Infectious Disease Prevention for State Administration of Traditional Chinese Medicine, Tianjin, ChinaTCM Key Research Laboratory for Infectious Disease Prevention for State Administration of Traditional Chinese Medicine, Tianjin, ChinaRehabilitation Department, Haihe Clinical School, Tianjin Medical University, Tianjin, ChinaDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, ChinaKey Laboratory of Post-trauma Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education and Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin Neurological Institute, Tianjin, ChinaDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, ChinaKey Laboratory of Post-trauma Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education and Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin Neurological Institute, Tianjin, ChinaDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, ChinaKey Laboratory of Post-trauma Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education and Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin Neurological Institute, Tianjin, ChinaDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, ChinaKey Laboratory of Post-trauma Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education and Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin Neurological Institute, Tianjin, ChinaDepartment of Neurology, Haihe Clinical School, Tianjin Medical University, Tianjin, ChinaTCM Key Research Laboratory for Infectious Disease Prevention for State Administration of Traditional Chinese Medicine, Tianjin, ChinaDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, ChinaKey Laboratory of Post-trauma Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education and Key Laboratory of Injuries, Variations and Regeneration of Nervous System, Tianjin Neurological Institute, Tianjin, ChinaObjectiveThis study aimed to analyze the cerebrospinal fluid (CSF) parameters affecting the outcomes of patients with tuberculous meningitis (TBM).MethodsThis is a multi-center, retrospective, cohort study involving 81 patients who were diagnosed with TBM and treated in Haihe Clinical College of Tianjin Medical University, Tianjin Medical University General Hospital, and General Hospital of Air Force PLA from January 2016 to December 2019. Baseline data, Glasgow Coma Scale (GCS) score, and clinical presentations of all patients were collected at admission. CSF samples were collected at 48 h, 1, 2, and 3 weeks after admission. CSF lactate, adenosine deaminase, chloride, protein, glucose levels and intracranial pressure were measured. After a follow-up of 16.14 ± 3.03 months, all patients were assessed using the modified Rankin Scale (mRS) and divided into good (mRS scores of 0–2 points) and poor outcome groups (mRS scores of 3–6 points). The differences in patients' baseline data, GCS score, clinical presentations, and levels of CSF parameters detected at 48 h, 1, 2, and 3 weeks after admission between two groups were compared. Statistically significant variables were added to the binary logistic regression model to identify the factors impacting the outcomes of patients with TBM. Receiver operating characteristic (ROC) curve was used to assess the predictive ability of the model.ResultsThe CSF lactate level exhibited a decreasing trend within 3 weeks of admission in the two groups. For the within-group comparison, statistically significant differences in the lactate level was found in both groups between four different time points. A binary logistic regression model revealed that CSF lactate level at 48 h after admission, age, and GSC score on admission were independently associated with the outcomes of patients with TBM. ROC curve analysis showed that the area under the ROC curve (AUC) was 0.786 for the CSF lactate level (48 h), 0.814 for GCS score, and 0.764 for age.ConclusionHigh CSF lactate level at 48 h after admission is one of the important factors for poor outcomes in patients with TBM.https://www.frontiersin.org/articles/10.3389/fneur.2022.989832/fulltuberculous meningitiscerebrospinal fluid examinationlactate levelprognostic factorsretrospective study |
| spellingShingle | Chenchao Liu Chenchao Liu Chenchao Liu Chenchao Liu Ruixue Huai Yijia Xiang Yijia Xiang Xu Han Xu Han Zixiang Chen Zixiang Chen Yuhan Liu Xingjun Liu Xingjun Liu Huiquan Liu Huiquan Liu Hong Zhang Hong Zhang Sihan Wang Sihan Wang Lingyu Hao Lingyu Hao Yin Bo Yin Bo Yuanbo Luo Yuanbo Luo Yiyi Wang Yiyi Wang Yi Wang Yi Wang High cerebrospinal fluid lactate concentration at 48 h of hospital admission predicts poor outcomes in patients with tuberculous meningitis: A multicenter retrospective cohort study Frontiers in Neurology tuberculous meningitis cerebrospinal fluid examination lactate level prognostic factors retrospective study |
| title | High cerebrospinal fluid lactate concentration at 48 h of hospital admission predicts poor outcomes in patients with tuberculous meningitis: A multicenter retrospective cohort study |
| title_full | High cerebrospinal fluid lactate concentration at 48 h of hospital admission predicts poor outcomes in patients with tuberculous meningitis: A multicenter retrospective cohort study |
| title_fullStr | High cerebrospinal fluid lactate concentration at 48 h of hospital admission predicts poor outcomes in patients with tuberculous meningitis: A multicenter retrospective cohort study |
| title_full_unstemmed | High cerebrospinal fluid lactate concentration at 48 h of hospital admission predicts poor outcomes in patients with tuberculous meningitis: A multicenter retrospective cohort study |
| title_short | High cerebrospinal fluid lactate concentration at 48 h of hospital admission predicts poor outcomes in patients with tuberculous meningitis: A multicenter retrospective cohort study |
| title_sort | high cerebrospinal fluid lactate concentration at 48 h of hospital admission predicts poor outcomes in patients with tuberculous meningitis a multicenter retrospective cohort study |
| topic | tuberculous meningitis cerebrospinal fluid examination lactate level prognostic factors retrospective study |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2022.989832/full |
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