Intergenerational implications of alcohol intake: metabolic disorders in alcohol-naïve rat offspring
Alcohol drinking may be associated with an increased risk of various metabolic diseases. Rat lines selectively bred for alcohol preference and alcohol avoidance constitute an interesting model to study inherited factors related to alcohol drinking and metabolic disorders. The aim of the present stud...
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PeerJ Inc.
2020-09-01
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| author | Pawel Mierzejewski Alicja Zakrzewska Julita Kuczyńska Edyta Wyszogrodzka Monika Dominiak |
| author_facet | Pawel Mierzejewski Alicja Zakrzewska Julita Kuczyńska Edyta Wyszogrodzka Monika Dominiak |
| author_sort | Pawel Mierzejewski |
| collection | DOAJ |
| description | Alcohol drinking may be associated with an increased risk of various metabolic diseases. Rat lines selectively bred for alcohol preference and alcohol avoidance constitute an interesting model to study inherited factors related to alcohol drinking and metabolic disorders. The aim of the present study was to compare the levels of selected laboratory biomarkers of metabolic disorders in blood samples from naïve offspring of Warsaw alcohol high-preferring (WHP), Warsaw alcohol low-preferring (WLP), and wild Wistar rats. Blood samples were collected from 3-month old (300–350 g) alcohol-naïve, male offspring of WHP (n = 8) and WLP rats (n = 8), as well as alcohol-naïve, male, wild Wistar rats. Markers of metabolic, hepatic, and pancreatic disorders were analysed (levels of homocysteine, glucose, total cholesterol, triglycerides and γ-glutamyl transferase (GGT), aspartate (AST), alanine aminotransferase (ALT), and amylase serum activities). Alcohol-naïve offspring of WHP, WLP, and wild Wistar rats differed significantly in the levels of triglycerides, total cholesterol, homocysteine, as well as in the activity of GGT, ALT, AST, and amylase enzymes. Most markers in the alcohol-naïve offspring of WHP rats were altered even thought they were never exposed to alcohol pre- or postnatally. This may suggest that parental alcohol abuse can have a detrimental influence on offspring vulnerability to metabolic disorders. |
| first_indexed | 2024-03-09T07:53:12Z |
| format | Article |
| id | doaj.art-00359529b5c0494f94368f1722da9ae4 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T07:53:12Z |
| publishDate | 2020-09-01 |
| publisher | PeerJ Inc. |
| record_format | Article |
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| spelling | doaj.art-00359529b5c0494f94368f1722da9ae42023-12-03T01:21:40ZengPeerJ Inc.PeerJ2167-83592020-09-018e988610.7717/peerj.9886Intergenerational implications of alcohol intake: metabolic disorders in alcohol-naïve rat offspringPawel Mierzejewski0Alicja Zakrzewska1Julita Kuczyńska2Edyta Wyszogrodzka3Monika Dominiak4Department of Pharmacology, Institute of Psychiatry and Neurology, Warsaw, PolandDepartment of Pharmacology, Institute of Psychiatry and Neurology, Warsaw, PolandDepartment of Pharmacology, Institute of Psychiatry and Neurology, Warsaw, PolandDepartment of Pharmacology, Institute of Psychiatry and Neurology, Warsaw, PolandDepartment of Pharmacology, Institute of Psychiatry and Neurology, Warsaw, PolandAlcohol drinking may be associated with an increased risk of various metabolic diseases. Rat lines selectively bred for alcohol preference and alcohol avoidance constitute an interesting model to study inherited factors related to alcohol drinking and metabolic disorders. The aim of the present study was to compare the levels of selected laboratory biomarkers of metabolic disorders in blood samples from naïve offspring of Warsaw alcohol high-preferring (WHP), Warsaw alcohol low-preferring (WLP), and wild Wistar rats. Blood samples were collected from 3-month old (300–350 g) alcohol-naïve, male offspring of WHP (n = 8) and WLP rats (n = 8), as well as alcohol-naïve, male, wild Wistar rats. Markers of metabolic, hepatic, and pancreatic disorders were analysed (levels of homocysteine, glucose, total cholesterol, triglycerides and γ-glutamyl transferase (GGT), aspartate (AST), alanine aminotransferase (ALT), and amylase serum activities). Alcohol-naïve offspring of WHP, WLP, and wild Wistar rats differed significantly in the levels of triglycerides, total cholesterol, homocysteine, as well as in the activity of GGT, ALT, AST, and amylase enzymes. Most markers in the alcohol-naïve offspring of WHP rats were altered even thought they were never exposed to alcohol pre- or postnatally. This may suggest that parental alcohol abuse can have a detrimental influence on offspring vulnerability to metabolic disorders.https://peerj.com/articles/9886.pdfAlcoholMetabolic disordersHomocysteineEpigeneticsAlcohol-preferring rats |
| spellingShingle | Pawel Mierzejewski Alicja Zakrzewska Julita Kuczyńska Edyta Wyszogrodzka Monika Dominiak Intergenerational implications of alcohol intake: metabolic disorders in alcohol-naïve rat offspring PeerJ Alcohol Metabolic disorders Homocysteine Epigenetics Alcohol-preferring rats |
| title | Intergenerational implications of alcohol intake: metabolic disorders in alcohol-naïve rat offspring |
| title_full | Intergenerational implications of alcohol intake: metabolic disorders in alcohol-naïve rat offspring |
| title_fullStr | Intergenerational implications of alcohol intake: metabolic disorders in alcohol-naïve rat offspring |
| title_full_unstemmed | Intergenerational implications of alcohol intake: metabolic disorders in alcohol-naïve rat offspring |
| title_short | Intergenerational implications of alcohol intake: metabolic disorders in alcohol-naïve rat offspring |
| title_sort | intergenerational implications of alcohol intake metabolic disorders in alcohol naive rat offspring |
| topic | Alcohol Metabolic disorders Homocysteine Epigenetics Alcohol-preferring rats |
| url | https://peerj.com/articles/9886.pdf |
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