Can Electrochemical Aptasensors Achieve the Commercial Success of Glucose Biosensors?
Abstract Enzymes and antibodies are widely available biorecognition elements in bioanalytical tools such as personal glucose monitoring (PGM) devices and lateral flow assays (LFA). Meanwhile, electrochemical aptamer‐based (EAB) sensors are promising affinity‐based bioanalytical tools with potential...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley-VCH
2024-04-01
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| Series: | Advanced Sensor Research |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/adsr.202300132 |
| _version_ | 1797214258189041664 |
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| author | Sina Ardalan Anna Ignaszak |
| author_facet | Sina Ardalan Anna Ignaszak |
| author_sort | Sina Ardalan |
| collection | DOAJ |
| description | Abstract Enzymes and antibodies are widely available biorecognition elements in bioanalytical tools such as personal glucose monitoring (PGM) devices and lateral flow assays (LFA). Meanwhile, electrochemical aptamer‐based (EAB) sensors are promising affinity‐based bioanalytical tools with potential advantages over such conventional bioassays. However, several critical factors affect the stability of EAB sensors, pivotal for their commercialization including 1) electrode defects due to surface treatment methods, 2) hampering effects of redox molecules, 3) electrical potential‐induced aptamer detachment, 4) thermal‐induced monolayer solubilization, 5) biochemical/enzymatic degradation, 6) biofouling, and 7) inadequate statistical design and analysis in EAB sensor fabrication. Herein, antidotes for the obstacles are proposed by applying novel surface treatment methods, adapting redox molecule, tuning electrochemical tests, tweaking backfilling agents, and anti‐bio‐fouling coatings. Nonetheless, the obstacles are a driving force to clear pathways toward bringing EAB sensors to the market for therapeutic drug and metabolite monitoring, point of care sensors, macromolecule detection, and pathogen diagnostics. |
| first_indexed | 2024-04-24T11:11:19Z |
| format | Article |
| id | doaj.art-0036b1e0a51a41f7a23747cf3638da46 |
| institution | Directory Open Access Journal |
| issn | 2751-1219 |
| language | English |
| last_indexed | 2024-04-24T11:11:19Z |
| publishDate | 2024-04-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Advanced Sensor Research |
| spelling | doaj.art-0036b1e0a51a41f7a23747cf3638da462024-04-11T13:29:08ZengWiley-VCHAdvanced Sensor Research2751-12192024-04-0134n/an/a10.1002/adsr.202300132Can Electrochemical Aptasensors Achieve the Commercial Success of Glucose Biosensors?Sina Ardalan0Anna Ignaszak1University of New Brunswick 30 Dineen Drive Fredericton NB E3B5A3 CanadaUniversity of New Brunswick 30 Dineen Drive Fredericton NB E3B5A3 CanadaAbstract Enzymes and antibodies are widely available biorecognition elements in bioanalytical tools such as personal glucose monitoring (PGM) devices and lateral flow assays (LFA). Meanwhile, electrochemical aptamer‐based (EAB) sensors are promising affinity‐based bioanalytical tools with potential advantages over such conventional bioassays. However, several critical factors affect the stability of EAB sensors, pivotal for their commercialization including 1) electrode defects due to surface treatment methods, 2) hampering effects of redox molecules, 3) electrical potential‐induced aptamer detachment, 4) thermal‐induced monolayer solubilization, 5) biochemical/enzymatic degradation, 6) biofouling, and 7) inadequate statistical design and analysis in EAB sensor fabrication. Herein, antidotes for the obstacles are proposed by applying novel surface treatment methods, adapting redox molecule, tuning electrochemical tests, tweaking backfilling agents, and anti‐bio‐fouling coatings. Nonetheless, the obstacles are a driving force to clear pathways toward bringing EAB sensors to the market for therapeutic drug and metabolite monitoring, point of care sensors, macromolecule detection, and pathogen diagnostics.https://doi.org/10.1002/adsr.202300132aptameraptasensorsbiorecognitionelectrochemical biosensorsself‐assembled monolayer |
| spellingShingle | Sina Ardalan Anna Ignaszak Can Electrochemical Aptasensors Achieve the Commercial Success of Glucose Biosensors? Advanced Sensor Research aptamer aptasensors biorecognition electrochemical biosensors self‐assembled monolayer |
| title | Can Electrochemical Aptasensors Achieve the Commercial Success of Glucose Biosensors? |
| title_full | Can Electrochemical Aptasensors Achieve the Commercial Success of Glucose Biosensors? |
| title_fullStr | Can Electrochemical Aptasensors Achieve the Commercial Success of Glucose Biosensors? |
| title_full_unstemmed | Can Electrochemical Aptasensors Achieve the Commercial Success of Glucose Biosensors? |
| title_short | Can Electrochemical Aptasensors Achieve the Commercial Success of Glucose Biosensors? |
| title_sort | can electrochemical aptasensors achieve the commercial success of glucose biosensors |
| topic | aptamer aptasensors biorecognition electrochemical biosensors self‐assembled monolayer |
| url | https://doi.org/10.1002/adsr.202300132 |
| work_keys_str_mv | AT sinaardalan canelectrochemicalaptasensorsachievethecommercialsuccessofglucosebiosensors AT annaignaszak canelectrochemicalaptasensorsachievethecommercialsuccessofglucosebiosensors |