Extracellular matrix metalloproteinase inducer in brain ischemia and intracerebral hemorrhage
Increasing evidence from preclinical and clinical studies link neuroinflammation to secondary brain injury after stroke, which includes brain ischemia and intracerebral hemorrhage (ICH). Extracellular matrix metalloproteinase inducer (EMMPRIN), a cell surface transmembrane protein, is a key factor i...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-08-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2022.986469/full |
| _version_ | 1797999784148074496 |
|---|---|
| author | Yang Liu Yang Liu Yanling Mu Yanling Mu Zhe Li Zhe Li Voon Wee Yong Mengzhou Xue Mengzhou Xue |
| author_facet | Yang Liu Yang Liu Yanling Mu Yanling Mu Zhe Li Zhe Li Voon Wee Yong Mengzhou Xue Mengzhou Xue |
| author_sort | Yang Liu |
| collection | DOAJ |
| description | Increasing evidence from preclinical and clinical studies link neuroinflammation to secondary brain injury after stroke, which includes brain ischemia and intracerebral hemorrhage (ICH). Extracellular matrix metalloproteinase inducer (EMMPRIN), a cell surface transmembrane protein, is a key factor in neuroinflammation. It is widely elevated in several cell types after stroke. The increased EMMPRIN appears to regulate the expression of matrix metalloproteinases (MMPs) and exacerbate the pathology of stroke-induced blood-brain barrier dysfunction, microvascular thrombosis and neuroinflammation. In light of the neurological effects of EMMPRIN, we present in this review the complex network of roles that EMMPRIN has in brain ischemia and ICH. We first introduce the structural features and biological roles of EMMPRIN, followed by a description of the increased expression of EMMPRIN in brain ischemia and ICH. Next, we discuss the pathophysiological roles of EMMPRIN in brain ischemia and ICH. In addition, we summarize several important treatments for stroke that target the EMMPRIN signaling pathway. Finally, we suggest that EMMPRIN may have prospects as a biomarker of stroke injury. Overall, this review collates experimental and clinical evidence of the role of EMMPRIN in stroke and provides insights into its pathological mechanisms. |
| first_indexed | 2024-04-11T11:10:16Z |
| format | Article |
| id | doaj.art-0036ff3ad86e4a5baf0ea168184fcf3e |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T11:10:16Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-0036ff3ad86e4a5baf0ea168184fcf3e2022-12-22T04:27:33ZengFrontiers Media S.A.Frontiers in Immunology1664-32242022-08-011310.3389/fimmu.2022.986469986469Extracellular matrix metalloproteinase inducer in brain ischemia and intracerebral hemorrhageYang Liu0Yang Liu1Yanling Mu2Yanling Mu3Zhe Li4Zhe Li5Voon Wee Yong6Mengzhou Xue7Mengzhou Xue8Department of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan International Joint Laboratory of Intracerebral Hemorrhage and Brain Injury, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan International Joint Laboratory of Intracerebral Hemorrhage and Brain Injury, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaDepartment of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan International Joint Laboratory of Intracerebral Hemorrhage and Brain Injury, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHotchkiss Brain Institute and Department of Clinical Neurosciences, University of Calgary, Calgary, AB, CanadaDepartment of Cerebrovascular Diseases, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaHenan International Joint Laboratory of Intracerebral Hemorrhage and Brain Injury, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, ChinaIncreasing evidence from preclinical and clinical studies link neuroinflammation to secondary brain injury after stroke, which includes brain ischemia and intracerebral hemorrhage (ICH). Extracellular matrix metalloproteinase inducer (EMMPRIN), a cell surface transmembrane protein, is a key factor in neuroinflammation. It is widely elevated in several cell types after stroke. The increased EMMPRIN appears to regulate the expression of matrix metalloproteinases (MMPs) and exacerbate the pathology of stroke-induced blood-brain barrier dysfunction, microvascular thrombosis and neuroinflammation. In light of the neurological effects of EMMPRIN, we present in this review the complex network of roles that EMMPRIN has in brain ischemia and ICH. We first introduce the structural features and biological roles of EMMPRIN, followed by a description of the increased expression of EMMPRIN in brain ischemia and ICH. Next, we discuss the pathophysiological roles of EMMPRIN in brain ischemia and ICH. In addition, we summarize several important treatments for stroke that target the EMMPRIN signaling pathway. Finally, we suggest that EMMPRIN may have prospects as a biomarker of stroke injury. Overall, this review collates experimental and clinical evidence of the role of EMMPRIN in stroke and provides insights into its pathological mechanisms.https://www.frontiersin.org/articles/10.3389/fimmu.2022.986469/fullExtracellular matrix metalloproteinase inducer (EMMPRIN)brain ischemiaintracerebral hemorrhagematrix metalloproteinasesneuroinflammation |
| spellingShingle | Yang Liu Yang Liu Yanling Mu Yanling Mu Zhe Li Zhe Li Voon Wee Yong Mengzhou Xue Mengzhou Xue Extracellular matrix metalloproteinase inducer in brain ischemia and intracerebral hemorrhage Frontiers in Immunology Extracellular matrix metalloproteinase inducer (EMMPRIN) brain ischemia intracerebral hemorrhage matrix metalloproteinases neuroinflammation |
| title | Extracellular matrix metalloproteinase inducer in brain ischemia and intracerebral hemorrhage |
| title_full | Extracellular matrix metalloproteinase inducer in brain ischemia and intracerebral hemorrhage |
| title_fullStr | Extracellular matrix metalloproteinase inducer in brain ischemia and intracerebral hemorrhage |
| title_full_unstemmed | Extracellular matrix metalloproteinase inducer in brain ischemia and intracerebral hemorrhage |
| title_short | Extracellular matrix metalloproteinase inducer in brain ischemia and intracerebral hemorrhage |
| title_sort | extracellular matrix metalloproteinase inducer in brain ischemia and intracerebral hemorrhage |
| topic | Extracellular matrix metalloproteinase inducer (EMMPRIN) brain ischemia intracerebral hemorrhage matrix metalloproteinases neuroinflammation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2022.986469/full |
| work_keys_str_mv | AT yangliu extracellularmatrixmetalloproteinaseinducerinbrainischemiaandintracerebralhemorrhage AT yangliu extracellularmatrixmetalloproteinaseinducerinbrainischemiaandintracerebralhemorrhage AT yanlingmu extracellularmatrixmetalloproteinaseinducerinbrainischemiaandintracerebralhemorrhage AT yanlingmu extracellularmatrixmetalloproteinaseinducerinbrainischemiaandintracerebralhemorrhage AT zheli extracellularmatrixmetalloproteinaseinducerinbrainischemiaandintracerebralhemorrhage AT zheli extracellularmatrixmetalloproteinaseinducerinbrainischemiaandintracerebralhemorrhage AT voonweeyong extracellularmatrixmetalloproteinaseinducerinbrainischemiaandintracerebralhemorrhage AT mengzhouxue extracellularmatrixmetalloproteinaseinducerinbrainischemiaandintracerebralhemorrhage AT mengzhouxue extracellularmatrixmetalloproteinaseinducerinbrainischemiaandintracerebralhemorrhage |