GABA Receptor Agonists Protect From Excitotoxic Damage Induced by AMPA in Oligodendrocytes

GABA Receptor Agonists Protect From Excitotoxic Damage Induced by AMPA in Oligodendrocytes

Oligodendrocytes are the myelin forming cells of the central nervous system, and their vulnerability to excitotoxicity induced by glutamate contributes to the pathogenesis of neurological disorders including brain ischemia and neurodegenerative diseases, such as multiple sclerosis. In addition to gl...

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Bibliographic Details
Main Authors: Laura Bayón-Cordero, Blanca Isabel Ochoa-Bueno, Asier Ruiz, Marina Ozalla, Carlos Matute, María Victoria Sánchez-Gómez
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Pharmacology
Subjects:
GABA receptor
oligodendrocyte
AMPA
baclofen
muscimol
excitotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.897056/full

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