Breaking satellite silence: human satellite II RNA expression in ovarian cancer
Multiple cancer types demonstrate abnormal expression of repetitive RNA sequences as a form of epigenetic instability. There is growing interest in understanding the role of repetitive RNAs in cancer pathogenesis and immunogenicity and in their potential role as diagnostic or therapeutic biomarkers....
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| Format: | Article |
| Language: | English |
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American Society for Clinical Investigation
2022-08-01
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| Series: | The Journal of Clinical Investigation |
| Online Access: | https://doi.org/10.1172/JCI161981 |
| _version_ | 1827768226579218432 |
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| author | Shridar Ganesan |
| author_facet | Shridar Ganesan |
| author_sort | Shridar Ganesan |
| collection | DOAJ |
| description | Multiple cancer types demonstrate abnormal expression of repetitive RNA sequences as a form of epigenetic instability. There is growing interest in understanding the role of repetitive RNAs in cancer pathogenesis and immunogenicity and in their potential role as diagnostic or therapeutic biomarkers. In this issue of the JCI, Porter and colleagues report on satellite RNA in a subset of ovarian cancers. The authors found that high expression of human satellite (HSAT) repeats — but not other families of repeats — was associated with an immunosuppressive phenotype in ovarian cancer cell lines and tumor samples. Further induction of HSAT RNA levels in vitro, surprisingly, leads to innate immune activation, suggesting a potential therapeutic strategy. This work highlights the expanding role of repetitive RNAs in tumor biology and the need to better define specific classes of repetitive elements expressed in cancer — as well as their role in tumorigenesis, tumor immunity, and the host response to cancer. |
| first_indexed | 2024-03-11T12:09:21Z |
| format | Article |
| id | doaj.art-00399ee10726469b86b6a0dfe19fb7a8 |
| institution | Directory Open Access Journal |
| issn | 1558-8238 |
| language | English |
| last_indexed | 2024-03-11T12:09:21Z |
| publishDate | 2022-08-01 |
| publisher | American Society for Clinical Investigation |
| record_format | Article |
| series | The Journal of Clinical Investigation |
| spelling | doaj.art-00399ee10726469b86b6a0dfe19fb7a82023-11-07T16:19:14ZengAmerican Society for Clinical InvestigationThe Journal of Clinical Investigation1558-82382022-08-0113216Breaking satellite silence: human satellite II RNA expression in ovarian cancerShridar GanesanMultiple cancer types demonstrate abnormal expression of repetitive RNA sequences as a form of epigenetic instability. There is growing interest in understanding the role of repetitive RNAs in cancer pathogenesis and immunogenicity and in their potential role as diagnostic or therapeutic biomarkers. In this issue of the JCI, Porter and colleagues report on satellite RNA in a subset of ovarian cancers. The authors found that high expression of human satellite (HSAT) repeats — but not other families of repeats — was associated with an immunosuppressive phenotype in ovarian cancer cell lines and tumor samples. Further induction of HSAT RNA levels in vitro, surprisingly, leads to innate immune activation, suggesting a potential therapeutic strategy. This work highlights the expanding role of repetitive RNAs in tumor biology and the need to better define specific classes of repetitive elements expressed in cancer — as well as their role in tumorigenesis, tumor immunity, and the host response to cancer.https://doi.org/10.1172/JCI161981 |
| spellingShingle | Shridar Ganesan Breaking satellite silence: human satellite II RNA expression in ovarian cancer The Journal of Clinical Investigation |
| title | Breaking satellite silence: human satellite II RNA expression in ovarian cancer |
| title_full | Breaking satellite silence: human satellite II RNA expression in ovarian cancer |
| title_fullStr | Breaking satellite silence: human satellite II RNA expression in ovarian cancer |
| title_full_unstemmed | Breaking satellite silence: human satellite II RNA expression in ovarian cancer |
| title_short | Breaking satellite silence: human satellite II RNA expression in ovarian cancer |
| title_sort | breaking satellite silence human satellite ii rna expression in ovarian cancer |
| url | https://doi.org/10.1172/JCI161981 |
| work_keys_str_mv | AT shridarganesan breakingsatellitesilencehumansatelliteiirnaexpressioninovariancancer |