An Updated Review of SARS-CoV-2 Vaccines and the Importance of Effective Vaccination Programs in Pandemic Times
Since the worldwide COVID-19 pandemic was declared a year ago, the search for vaccines has become the top priority in order to restore normalcy after 2.5 million deaths worldwide, overloaded sanitary systems, and a huge economic burden. Vaccine development has represented a step towards the desired...
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-04-01
|
| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/9/5/433 |
| _version_ | 1797536086745939968 |
|---|---|
| author | Cielo García-Montero Oscar Fraile-Martínez Coral Bravo Diego Torres-Carranza Lara Sanchez-Trujillo Ana M. Gómez-Lahoz Luis G. Guijarro Natalio García-Honduvilla Angel Asúnsolo Julia Bujan Jorge Monserrat Encarnación Serrano Melchor Álvarez-Mon Juan A De León-Luis Miguel A. Álvarez-Mon Miguel A. Ortega |
| author_facet | Cielo García-Montero Oscar Fraile-Martínez Coral Bravo Diego Torres-Carranza Lara Sanchez-Trujillo Ana M. Gómez-Lahoz Luis G. Guijarro Natalio García-Honduvilla Angel Asúnsolo Julia Bujan Jorge Monserrat Encarnación Serrano Melchor Álvarez-Mon Juan A De León-Luis Miguel A. Álvarez-Mon Miguel A. Ortega |
| author_sort | Cielo García-Montero |
| collection | DOAJ |
| description | Since the worldwide COVID-19 pandemic was declared a year ago, the search for vaccines has become the top priority in order to restore normalcy after 2.5 million deaths worldwide, overloaded sanitary systems, and a huge economic burden. Vaccine development has represented a step towards the desired herd immunity in a short period of time, owing to a high level of investment, the focus of researchers, and the urge for the authorization of the faster administration of vaccines. Nevertheless, this objective may only be achieved by pursuing effective strategies and policies in various countries worldwide. In the present review, some aspects involved in accomplishing a successful vaccination program are addressed, in addition to the importance of vaccination in a pandemic in the face of unwillingness, conspiracy theories, or a lack of information among the public. Moreover, we provide some updated points related to the landscape of the clinical development of vaccine candidates, specifically, the top five vaccines that are already being assessed in Phase IV clinical trials (BNT162b2, mRNA-1273, AZD1222, Ad26.COV2.S, and CoronaVac). |
| first_indexed | 2024-03-10T11:54:38Z |
| format | Article |
| id | doaj.art-003b55a109ca4d75b3e1785d4cde004e |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-10T11:54:38Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-003b55a109ca4d75b3e1785d4cde004e2023-11-21T17:22:49ZengMDPI AGVaccines2076-393X2021-04-019543310.3390/vaccines9050433An Updated Review of SARS-CoV-2 Vaccines and the Importance of Effective Vaccination Programs in Pandemic TimesCielo García-Montero0Oscar Fraile-Martínez1Coral Bravo2Diego Torres-Carranza3Lara Sanchez-Trujillo4Ana M. Gómez-Lahoz5Luis G. Guijarro6Natalio García-Honduvilla7Angel Asúnsolo8Julia Bujan9Jorge Monserrat10Encarnación Serrano11Melchor Álvarez-Mon12Juan A De León-Luis13Miguel A. Álvarez-Mon14Miguel A. Ortega15Department of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, SpainFirst of May Health Centre, Health Area I, Rivas Vaciamadrid, 28521 Madrid, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainUnit of Biochemistry and Molecular Biology (CIBEREHD), Department of System Biology, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainRamón y Cajal Institute of Sanitary Research (IRYCIS), 28034 Madrid, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainLos fresnos of Health Centre, Health Area III, Torrejon de Ardoz, 28850 Madrid, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Obstetrics and Gynecology, University Hospital Gregorio Marañón, 28009 Madrid, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcalá de Henares, SpainSince the worldwide COVID-19 pandemic was declared a year ago, the search for vaccines has become the top priority in order to restore normalcy after 2.5 million deaths worldwide, overloaded sanitary systems, and a huge economic burden. Vaccine development has represented a step towards the desired herd immunity in a short period of time, owing to a high level of investment, the focus of researchers, and the urge for the authorization of the faster administration of vaccines. Nevertheless, this objective may only be achieved by pursuing effective strategies and policies in various countries worldwide. In the present review, some aspects involved in accomplishing a successful vaccination program are addressed, in addition to the importance of vaccination in a pandemic in the face of unwillingness, conspiracy theories, or a lack of information among the public. Moreover, we provide some updated points related to the landscape of the clinical development of vaccine candidates, specifically, the top five vaccines that are already being assessed in Phase IV clinical trials (BNT162b2, mRNA-1273, AZD1222, Ad26.COV2.S, and CoronaVac).https://www.mdpi.com/2076-393X/9/5/433SARS-CoV-2coronavirusCOVID-19vaccination programsvaccine acceptancevaccine hesitancy |
| spellingShingle | Cielo García-Montero Oscar Fraile-Martínez Coral Bravo Diego Torres-Carranza Lara Sanchez-Trujillo Ana M. Gómez-Lahoz Luis G. Guijarro Natalio García-Honduvilla Angel Asúnsolo Julia Bujan Jorge Monserrat Encarnación Serrano Melchor Álvarez-Mon Juan A De León-Luis Miguel A. Álvarez-Mon Miguel A. Ortega An Updated Review of SARS-CoV-2 Vaccines and the Importance of Effective Vaccination Programs in Pandemic Times Vaccines SARS-CoV-2 coronavirus COVID-19 vaccination programs vaccine acceptance vaccine hesitancy |
| title | An Updated Review of SARS-CoV-2 Vaccines and the Importance of Effective Vaccination Programs in Pandemic Times |
| title_full | An Updated Review of SARS-CoV-2 Vaccines and the Importance of Effective Vaccination Programs in Pandemic Times |
| title_fullStr | An Updated Review of SARS-CoV-2 Vaccines and the Importance of Effective Vaccination Programs in Pandemic Times |
| title_full_unstemmed | An Updated Review of SARS-CoV-2 Vaccines and the Importance of Effective Vaccination Programs in Pandemic Times |
| title_short | An Updated Review of SARS-CoV-2 Vaccines and the Importance of Effective Vaccination Programs in Pandemic Times |
| title_sort | updated review of sars cov 2 vaccines and the importance of effective vaccination programs in pandemic times |
| topic | SARS-CoV-2 coronavirus COVID-19 vaccination programs vaccine acceptance vaccine hesitancy |
| url | https://www.mdpi.com/2076-393X/9/5/433 |
| work_keys_str_mv | AT cielogarciamontero anupdatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT oscarfrailemartinez anupdatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT coralbravo anupdatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT diegotorrescarranza anupdatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT larasancheztrujillo anupdatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT anamgomezlahoz anupdatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT luisgguijarro anupdatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT nataliogarciahonduvilla anupdatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT angelasunsolo anupdatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT juliabujan anupdatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT jorgemonserrat anupdatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT encarnacionserrano anupdatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT melchoralvarezmon anupdatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT juanadeleonluis anupdatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT miguelaalvarezmon anupdatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT miguelaortega anupdatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT cielogarciamontero updatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT oscarfrailemartinez updatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT coralbravo updatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT diegotorrescarranza updatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT larasancheztrujillo updatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT anamgomezlahoz updatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT luisgguijarro updatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT nataliogarciahonduvilla updatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT angelasunsolo updatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT juliabujan updatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT jorgemonserrat updatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT encarnacionserrano updatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT melchoralvarezmon updatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT juanadeleonluis updatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT miguelaalvarezmon updatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes AT miguelaortega updatedreviewofsarscov2vaccinesandtheimportanceofeffectivevaccinationprogramsinpandemictimes |