Experimental Models to Study Skin Wound Healing with a Focus on Angiogenesis

A large number of models are now available for the investigation of skin wound healing. These can be used to study the processes that take place in a phase-specific manner under both physiological and pathological conditions. Most models focus on wound closure, which is a crucial parameter for wound...

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Main Authors: Eberhard Grambow, Heiko Sorg, Christian G. G. Sorg, Daniel Strüder
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Medical Sciences
Subjects:
Online Access:https://www.mdpi.com/2076-3271/9/3/55
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author Eberhard Grambow
Heiko Sorg
Christian G. G. Sorg
Daniel Strüder
author_facet Eberhard Grambow
Heiko Sorg
Christian G. G. Sorg
Daniel Strüder
author_sort Eberhard Grambow
collection DOAJ
description A large number of models are now available for the investigation of skin wound healing. These can be used to study the processes that take place in a phase-specific manner under both physiological and pathological conditions. Most models focus on wound closure, which is a crucial parameter for wound healing. However, vascular supply plays an equally important role and corresponding models for selective or parallel investigation of microcirculation regeneration and angiogenesis are also described. In this review article, we therefore focus on the different levels of investigation of skin wound healing (in vivo to in virtuo) and the investigation of angiogenesis and its parameters.
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spelling doaj.art-003e674b8a0c488ca57f00243fa2ae0b2023-11-22T14:09:44ZengMDPI AGMedical Sciences2076-32712021-08-01935510.3390/medsci9030055Experimental Models to Study Skin Wound Healing with a Focus on AngiogenesisEberhard Grambow0Heiko Sorg1Christian G. G. Sorg2Daniel Strüder3Department of General, Visceral, Thoracic, Vascular and Transplantation Surgery, Rostock University Medical Center, 18057 Rostock, GermanyDepartment of Health, University of Witten/Herdecke, Alfred-Herrhausen-Str. 50, 58455 Witten, GermanyChair of Management and Innovation in Health Care, Department of Management and Entrepreneurship, Faculty of Management, Economics and Society, Witten/Herdecke University, Alfred-Herrhausen-Straße 50, 58455 Witten, GermanyDepartment of Oto-Rhino-Laryngology, Head and Neck Surgery “Otto Körner”, Rostock University Medical Center, 18057 Rostock, GermanyA large number of models are now available for the investigation of skin wound healing. These can be used to study the processes that take place in a phase-specific manner under both physiological and pathological conditions. Most models focus on wound closure, which is a crucial parameter for wound healing. However, vascular supply plays an equally important role and corresponding models for selective or parallel investigation of microcirculation regeneration and angiogenesis are also described. In this review article, we therefore focus on the different levels of investigation of skin wound healing (in vivo to in virtuo) and the investigation of angiogenesis and its parameters.https://www.mdpi.com/2076-3271/9/3/55dorsal skin fold chamberchorion-allantois modelrabbitmouseearin virtuo
spellingShingle Eberhard Grambow
Heiko Sorg
Christian G. G. Sorg
Daniel Strüder
Experimental Models to Study Skin Wound Healing with a Focus on Angiogenesis
Medical Sciences
dorsal skin fold chamber
chorion-allantois model
rabbit
mouse
ear
in virtuo
title Experimental Models to Study Skin Wound Healing with a Focus on Angiogenesis
title_full Experimental Models to Study Skin Wound Healing with a Focus on Angiogenesis
title_fullStr Experimental Models to Study Skin Wound Healing with a Focus on Angiogenesis
title_full_unstemmed Experimental Models to Study Skin Wound Healing with a Focus on Angiogenesis
title_short Experimental Models to Study Skin Wound Healing with a Focus on Angiogenesis
title_sort experimental models to study skin wound healing with a focus on angiogenesis
topic dorsal skin fold chamber
chorion-allantois model
rabbit
mouse
ear
in virtuo
url https://www.mdpi.com/2076-3271/9/3/55
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