Prevalence of vitamin D deficiency in PLHIV and its relation to CD4 count and ART: A cross sectional study
Introduction: HIV (Human Immunodeficiency Virus) continues to be a major global public health issue with no cure. Vitamin D is a fat-soluble hormone that is majorly involved in the classical function of calcium and phosphorus hemostasis and bone mineralization as well as non-classical functions of i...
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| Format: | Article |
| Language: | English |
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Al Ameen Medical College
2024-01-01
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| Series: | Al Ameen Journal of Medical Sciences |
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| Online Access: | http://ajms.alameenmedical.org/ArticlePDFs/16%20AJMS%20V17.N1.2024%20p%2090-95.pdf |
| _version_ | 1797360769672675328 |
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| author | Himeshwari Verma Devpriya Lakra Vyom Agarwal |
| author_facet | Himeshwari Verma Devpriya Lakra Vyom Agarwal |
| author_sort | Himeshwari Verma |
| collection | DOAJ |
| description | Introduction: HIV (Human Immunodeficiency Virus) continues to be a major global public health issue with no cure. Vitamin D is a fat-soluble hormone that is majorly involved in the classical function of calcium and phosphorus hemostasis and bone mineralization as well as non-classical functions of immune modulation in various viral and autoimmune diseases. A combination of both traditional risk factors, HIV- specific and antiretroviral therapy (ART)-specific contributors leave HIV-infected persons (PLHIV) at a greater risk for low 25-OH-Vitamin D levels and frank vitamin D deficiency. Aims and Setting: The current study was conducted to assess and characterize the prevalence of Vitamin D deficiency in PLHIV-on-ART attending a tertiary care hospital and assess the factors that may be affecting it. Methods: 95 PLHIV registered at an ART center were selected over a period of 6 months based on Inclusion and Exclusion criteria. Flow cytometry estimation of CD4 count and ELISA based quantitative assessment of serum 25-OH Vitamin D3 were done along with detailed clinical examination. P<0.05 was considered to be statistically significant. Results: About half of the PLHIV assessed were deficient in vitamin D. Severe vitamin D deficiency was noted in one-fourth of subjects. Serum vitamin D levels were significantly less in subjects on ZLN regime compared to TLE regime. No significant difference was found between vitamin D deficiency and duration of treatment, different treatment regimens or differing CD4 counts. No significant association of serum levels of Vitamin D with duration of treatment or varying CD4 count was found. Conclusion: There is greater prevalence of subnormal levels of Vitamin D in PLHIV on ART. ZLN regime appears to have a negative impact on Vitamin D levels in comparison to TLE regimen. More research needs to be done to further evaluate the physiology of Vitamin D in PLHIV on ART. |
| first_indexed | 2024-03-08T15:44:27Z |
| format | Article |
| id | doaj.art-00411c2721b542528701bd1edc0b341c |
| institution | Directory Open Access Journal |
| issn | 0974-1143 |
| language | English |
| last_indexed | 2024-03-08T15:44:27Z |
| publishDate | 2024-01-01 |
| publisher | Al Ameen Medical College |
| record_format | Article |
| series | Al Ameen Journal of Medical Sciences |
| spelling | doaj.art-00411c2721b542528701bd1edc0b341c2024-01-09T11:51:20ZengAl Ameen Medical CollegeAl Ameen Journal of Medical Sciences0974-11432024-01-0117019095Prevalence of vitamin D deficiency in PLHIV and its relation to CD4 count and ART: A cross sectional studyHimeshwari Verma0Devpriya Lakra1Vyom Agarwal2Department of General Medicine, Pt. Jawahar Lal Nehru Memorial Medical College, & Dr. BRAM Hospital, Jail Road, Raipur-492001, Chhattisgarh, IndiaDepartment of General Medicine, Pt. Jawahar Lal Nehru Memorial Medical College, & Dr. BRAM Hospital, Jail Road, Raipur-492001, Chhattisgarh, IndiaDepartment of General Medicine, Pt. Jawahar Lal Nehru Memorial Medical College, & Dr. BRAM Hospital, Jail Road, Raipur-492001, Chhattisgarh, IndiaIntroduction: HIV (Human Immunodeficiency Virus) continues to be a major global public health issue with no cure. Vitamin D is a fat-soluble hormone that is majorly involved in the classical function of calcium and phosphorus hemostasis and bone mineralization as well as non-classical functions of immune modulation in various viral and autoimmune diseases. A combination of both traditional risk factors, HIV- specific and antiretroviral therapy (ART)-specific contributors leave HIV-infected persons (PLHIV) at a greater risk for low 25-OH-Vitamin D levels and frank vitamin D deficiency. Aims and Setting: The current study was conducted to assess and characterize the prevalence of Vitamin D deficiency in PLHIV-on-ART attending a tertiary care hospital and assess the factors that may be affecting it. Methods: 95 PLHIV registered at an ART center were selected over a period of 6 months based on Inclusion and Exclusion criteria. Flow cytometry estimation of CD4 count and ELISA based quantitative assessment of serum 25-OH Vitamin D3 were done along with detailed clinical examination. P<0.05 was considered to be statistically significant. Results: About half of the PLHIV assessed were deficient in vitamin D. Severe vitamin D deficiency was noted in one-fourth of subjects. Serum vitamin D levels were significantly less in subjects on ZLN regime compared to TLE regime. No significant difference was found between vitamin D deficiency and duration of treatment, different treatment regimens or differing CD4 counts. No significant association of serum levels of Vitamin D with duration of treatment or varying CD4 count was found. Conclusion: There is greater prevalence of subnormal levels of Vitamin D in PLHIV on ART. ZLN regime appears to have a negative impact on Vitamin D levels in comparison to TLE regimen. More research needs to be done to further evaluate the physiology of Vitamin D in PLHIV on ART.http://ajms.alameenmedical.org/ArticlePDFs/16%20AJMS%20V17.N1.2024%20p%2090-95.pdfhivinternal medicineinfectious disease medicinemedicinenutritional sciencesplhivplhavitamin d |
| spellingShingle | Himeshwari Verma Devpriya Lakra Vyom Agarwal Prevalence of vitamin D deficiency in PLHIV and its relation to CD4 count and ART: A cross sectional study Al Ameen Journal of Medical Sciences hiv internal medicine infectious disease medicine medicine nutritional sciences plhiv plha vitamin d |
| title | Prevalence of vitamin D deficiency in PLHIV and its relation to CD4 count and ART: A cross sectional study |
| title_full | Prevalence of vitamin D deficiency in PLHIV and its relation to CD4 count and ART: A cross sectional study |
| title_fullStr | Prevalence of vitamin D deficiency in PLHIV and its relation to CD4 count and ART: A cross sectional study |
| title_full_unstemmed | Prevalence of vitamin D deficiency in PLHIV and its relation to CD4 count and ART: A cross sectional study |
| title_short | Prevalence of vitamin D deficiency in PLHIV and its relation to CD4 count and ART: A cross sectional study |
| title_sort | prevalence of vitamin d deficiency in plhiv and its relation to cd4 count and art a cross sectional study |
| topic | hiv internal medicine infectious disease medicine medicine nutritional sciences plhiv plha vitamin d |
| url | http://ajms.alameenmedical.org/ArticlePDFs/16%20AJMS%20V17.N1.2024%20p%2090-95.pdf |
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