Effects of Curcumin in a Mouse Model of Very High Fat Diet-Induced Obesity
Worldwide rates of Western-diet-induced obesity epidemics are growing dramatically. Being linked with numerous comorbidities and complications, including cardiovascular disease, type 2 diabetes, cancer, chronic inflammation, and osteoarthritis (OA), obesity represents one of the most threatening cha...
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MDPI AG
2020-09-01
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| Series: | Biomolecules |
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| Online Access: | https://www.mdpi.com/2218-273X/10/10/1368 |
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| author | Iurii Koboziev Shane Scoggin Xiaoxia Gong Parvin Mirzaei Masoud Zabet-Moghaddam Mohammad Yosofvand Hanna Moussa Yava Jones-Hall Naima Moustaid-Moussa |
| author_facet | Iurii Koboziev Shane Scoggin Xiaoxia Gong Parvin Mirzaei Masoud Zabet-Moghaddam Mohammad Yosofvand Hanna Moussa Yava Jones-Hall Naima Moustaid-Moussa |
| author_sort | Iurii Koboziev |
| collection | DOAJ |
| description | Worldwide rates of Western-diet-induced obesity epidemics are growing dramatically. Being linked with numerous comorbidities and complications, including cardiovascular disease, type 2 diabetes, cancer, chronic inflammation, and osteoarthritis (OA), obesity represents one of the most threatening challenges for modern healthcare. Mouse models are an invaluable tool for investigating the effects of diets and their bioactive components against high fat diet (HFD)-induced obesity and its comorbidities. During recent years, very high fat diets (VHFDs), providing 58–60% kcal fat, have become a popular alternative to more traditional HFDs, providing 40–45% total kcal fat, due to the faster induction of obesity and stronger metabolic responses. This project aims to investigate if the 60% fat VHFD is suitable to evaluate the protective effects of curcumin in diet-induced obesity and osteoarthritis. B6 male mice, prone to diet-induced metabolic dysfunction, were supplemented with VHFD without or with curcumin for 13 weeks. Under these experimental conditions, feeding mice a VHFD for 13 weeks did not result in expected robust manifestations of the targeted pathophysiologic conditions. Supplementing the diet with curcumin, in turn, protected the animals against obesity without significant changes in white adipocyte size, glucose clearance, and knee cartilage integrity. Additional research is needed to optimize diet composition, curcumin dosage, and duration of dietary interventions to establish the VHFD-induced obesity for evaluating the effects of curcumin on metabolic dysfunctions related to obesity and osteoarthritis. |
| first_indexed | 2024-03-10T16:02:19Z |
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| issn | 2218-273X |
| language | English |
| last_indexed | 2024-03-10T16:02:19Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
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| series | Biomolecules |
| spelling | doaj.art-0041fc27ea474fbeab665f55c7e615c32023-11-20T15:07:55ZengMDPI AGBiomolecules2218-273X2020-09-011010136810.3390/biom10101368Effects of Curcumin in a Mouse Model of Very High Fat Diet-Induced ObesityIurii Koboziev0Shane Scoggin1Xiaoxia Gong2Parvin Mirzaei3Masoud Zabet-Moghaddam4Mohammad Yosofvand5Hanna Moussa6Yava Jones-Hall7Naima Moustaid-Moussa8Department of Nutritional Sciences, Texas Tech University, College of Human Sciences, Lubbock, TX 79409-1270, USADepartment of Nutritional Sciences, Texas Tech University, College of Human Sciences, Lubbock, TX 79409-1270, USACenter for Biotechnology and Genomics, Texas Tech University, Canton & Main Experimental Sciences Building, Lubbock, TX 79409-3132, USACenter for Biotechnology and Genomics, Texas Tech University, Canton & Main Experimental Sciences Building, Lubbock, TX 79409-3132, USAObesity Research Institute, Texas Tech University, College of Human Sciences, Lubbock, TX 79409-1270, USADepartment of Mechanical Engineering, Texas Tech University, 100 Engineering Center Box 43103, Lubbock, TX 79409-3103, USAObesity Research Institute, Texas Tech University, College of Human Sciences, Lubbock, TX 79409-1270, USADepartment of Comparative Pathobiology, Purdue University, 725 Harrison St, West Lafayette, IN 47907, USADepartment of Nutritional Sciences, Texas Tech University, College of Human Sciences, Lubbock, TX 79409-1270, USAWorldwide rates of Western-diet-induced obesity epidemics are growing dramatically. Being linked with numerous comorbidities and complications, including cardiovascular disease, type 2 diabetes, cancer, chronic inflammation, and osteoarthritis (OA), obesity represents one of the most threatening challenges for modern healthcare. Mouse models are an invaluable tool for investigating the effects of diets and their bioactive components against high fat diet (HFD)-induced obesity and its comorbidities. During recent years, very high fat diets (VHFDs), providing 58–60% kcal fat, have become a popular alternative to more traditional HFDs, providing 40–45% total kcal fat, due to the faster induction of obesity and stronger metabolic responses. This project aims to investigate if the 60% fat VHFD is suitable to evaluate the protective effects of curcumin in diet-induced obesity and osteoarthritis. B6 male mice, prone to diet-induced metabolic dysfunction, were supplemented with VHFD without or with curcumin for 13 weeks. Under these experimental conditions, feeding mice a VHFD for 13 weeks did not result in expected robust manifestations of the targeted pathophysiologic conditions. Supplementing the diet with curcumin, in turn, protected the animals against obesity without significant changes in white adipocyte size, glucose clearance, and knee cartilage integrity. Additional research is needed to optimize diet composition, curcumin dosage, and duration of dietary interventions to establish the VHFD-induced obesity for evaluating the effects of curcumin on metabolic dysfunctions related to obesity and osteoarthritis.https://www.mdpi.com/2218-273X/10/10/1368mouse modelsvery high fat dietobesityosteoarthritischronic inflammationcurcumin |
| spellingShingle | Iurii Koboziev Shane Scoggin Xiaoxia Gong Parvin Mirzaei Masoud Zabet-Moghaddam Mohammad Yosofvand Hanna Moussa Yava Jones-Hall Naima Moustaid-Moussa Effects of Curcumin in a Mouse Model of Very High Fat Diet-Induced Obesity Biomolecules mouse models very high fat diet obesity osteoarthritis chronic inflammation curcumin |
| title | Effects of Curcumin in a Mouse Model of Very High Fat Diet-Induced Obesity |
| title_full | Effects of Curcumin in a Mouse Model of Very High Fat Diet-Induced Obesity |
| title_fullStr | Effects of Curcumin in a Mouse Model of Very High Fat Diet-Induced Obesity |
| title_full_unstemmed | Effects of Curcumin in a Mouse Model of Very High Fat Diet-Induced Obesity |
| title_short | Effects of Curcumin in a Mouse Model of Very High Fat Diet-Induced Obesity |
| title_sort | effects of curcumin in a mouse model of very high fat diet induced obesity |
| topic | mouse models very high fat diet obesity osteoarthritis chronic inflammation curcumin |
| url | https://www.mdpi.com/2218-273X/10/10/1368 |
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