A Marine λ-Oligocarrageenan Inhibits Migratory and Invasive Ability of MDA-MB-231 Human Breast Cancer Cells through Actions on Heparanase Metabolism and MMP-14/MMP-2 Axis

A Marine λ-Oligocarrageenan Inhibits Migratory and Invasive Ability of MDA-MB-231 Human Breast Cancer Cells through Actions on Heparanase Metabolism and MMP-14/MMP-2 Axis

Sugar-based molecules such as heparins or natural heparan sulfate polysaccharides have been developed and widely studied for controlling heparanase (HPSE) enzymatic activity, a key player in extracellular matrix remodelling during cancer pathogenesis. However, non-enzymatic functions of HPSE have al...

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Bibliographic Details
Main Authors: Rémi Cousin, Hugo Groult, Chanez Manseur, Romain Ferru-Clément, Mario Gani, Rachel Havret, Claire Toucheteau, Grégoire Prunier, Béatrice Colin, Franck Morel, Jean-Marie Piot, Isabelle Lanneluc, Kévin Baranger, Thierry Maugard, Ingrid Fruitier-Arnaudin
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Marine Drugs
Subjects:
polysaccharide
oligosaccharide
heparin
λ-carrageenan
heparanase
metalloproteinase
Online Access:https://www.mdpi.com/1660-3397/19/10/546

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