Acute kidney injury in patients with acute-on-chronic liver failure: clinical significance and management
Acute-on-chronic-liver failure (ACLF) refers to a phenomenon in which patients with chronic liver disease develop multiple organ failure due to acute exacerbation of underlying liver disease. More than 10 definitions of ACLF are extant around the world, and there is lack of consensus on whether extr...
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| Format: | Article |
| Language: | English |
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The Korean Society of Nephrology
2023-05-01
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| Series: | Kidney Research and Clinical Practice |
| Subjects: | |
| Online Access: | http://www.krcp-ksn.org/upload/pdf/j-krcp-22-264.pdf |
| _version_ | 1827824933298765824 |
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| author | Jeong-Ju Yoo Moo Yong Park Sang Gyune Kim |
| author_facet | Jeong-Ju Yoo Moo Yong Park Sang Gyune Kim |
| author_sort | Jeong-Ju Yoo |
| collection | DOAJ |
| description | Acute-on-chronic-liver failure (ACLF) refers to a phenomenon in which patients with chronic liver disease develop multiple organ failure due to acute exacerbation of underlying liver disease. More than 10 definitions of ACLF are extant around the world, and there is lack of consensus on whether extrahepatic organ failure is a main component or a consequence of ACLF. Asian and European consortiums have their own definitions of ACLF. The Asian Pacific Association for the Study of the Liver ACLF Research Consortium does not consider kidney failure as a diagnostic criterion for ACLF. Meanwhile, the European Association for the Study of the Liver Chronic Liver Failure and the North American Consortium for the Study of End-stage Liver Disease do consider kidney failure as an important factor in diagnosing and assessing the severity of ACLF. When kidney failure occurs in ACLF patients, treatment varies depending on the presence and stage of acute kidney injury (AKI). In general, the diagnosis of AKI in cirrhotic patients is based on the International Club of Ascites criteria: an increase of 0.3 mg/dL or more within 48 hours or a serum creatinine increase of 50% or more within one week. This study underscores the importance of kidney failure or AKI in patients with ACLF by reviewing its pathophysiology, prevention methods, and treatment approaches. |
| first_indexed | 2024-03-12T02:33:25Z |
| format | Article |
| id | doaj.art-004669cf371a4c8084a2b217dc7823c3 |
| institution | Directory Open Access Journal |
| issn | 2211-9132 2211-9140 |
| language | English |
| last_indexed | 2024-03-12T02:33:25Z |
| publishDate | 2023-05-01 |
| publisher | The Korean Society of Nephrology |
| record_format | Article |
| series | Kidney Research and Clinical Practice |
| spelling | doaj.art-004669cf371a4c8084a2b217dc7823c32023-09-05T01:23:54ZengThe Korean Society of NephrologyKidney Research and Clinical Practice2211-91322211-91402023-05-0142328629710.23876/j.krcp.22.2646227Acute kidney injury in patients with acute-on-chronic liver failure: clinical significance and managementJeong-Ju Yoo0Moo Yong Park1Sang Gyune Kim2 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University School of Medicine, Bucheon, Republic of Korea Division of Nephrology, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University School of Medicine, Bucheon, Republic of Korea Division of Gastroenterology and Hepatology, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, Soonchunhyang University School of Medicine, Bucheon, Republic of KoreaAcute-on-chronic-liver failure (ACLF) refers to a phenomenon in which patients with chronic liver disease develop multiple organ failure due to acute exacerbation of underlying liver disease. More than 10 definitions of ACLF are extant around the world, and there is lack of consensus on whether extrahepatic organ failure is a main component or a consequence of ACLF. Asian and European consortiums have their own definitions of ACLF. The Asian Pacific Association for the Study of the Liver ACLF Research Consortium does not consider kidney failure as a diagnostic criterion for ACLF. Meanwhile, the European Association for the Study of the Liver Chronic Liver Failure and the North American Consortium for the Study of End-stage Liver Disease do consider kidney failure as an important factor in diagnosing and assessing the severity of ACLF. When kidney failure occurs in ACLF patients, treatment varies depending on the presence and stage of acute kidney injury (AKI). In general, the diagnosis of AKI in cirrhotic patients is based on the International Club of Ascites criteria: an increase of 0.3 mg/dL or more within 48 hours or a serum creatinine increase of 50% or more within one week. This study underscores the importance of kidney failure or AKI in patients with ACLF by reviewing its pathophysiology, prevention methods, and treatment approaches.http://www.krcp-ksn.org/upload/pdf/j-krcp-22-264.pdfacute kidney injuryacute-on-chronic-liver failurerenal insufficiency |
| spellingShingle | Jeong-Ju Yoo Moo Yong Park Sang Gyune Kim Acute kidney injury in patients with acute-on-chronic liver failure: clinical significance and management Kidney Research and Clinical Practice acute kidney injury acute-on-chronic-liver failure renal insufficiency |
| title | Acute kidney injury in patients with acute-on-chronic liver failure: clinical significance and management |
| title_full | Acute kidney injury in patients with acute-on-chronic liver failure: clinical significance and management |
| title_fullStr | Acute kidney injury in patients with acute-on-chronic liver failure: clinical significance and management |
| title_full_unstemmed | Acute kidney injury in patients with acute-on-chronic liver failure: clinical significance and management |
| title_short | Acute kidney injury in patients with acute-on-chronic liver failure: clinical significance and management |
| title_sort | acute kidney injury in patients with acute on chronic liver failure clinical significance and management |
| topic | acute kidney injury acute-on-chronic-liver failure renal insufficiency |
| url | http://www.krcp-ksn.org/upload/pdf/j-krcp-22-264.pdf |
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