Glass as a biomaterial: strategies for optimising bioactive glasses for clinical applications
Bioactive glasses were the first synthetic materials to bond to human body tissue, making them ideal for replacing and regenerating bone. Since their first development over half a century ago, many new bioactive glass compositions have been developed for medicine and dentistry. This paper looks at d...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Académie des sciences
2022-07-01
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| Series: | Comptes Rendus. Géoscience |
| Subjects: | |
| Online Access: | https://comptes-rendus.academie-sciences.fr/geoscience/articles/10.5802/crgeos.134/ |
| _version_ | 1797517909008842752 |
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| author | Brauer, Delia S. Hupa, Leena |
| author_facet | Brauer, Delia S. Hupa, Leena |
| author_sort | Brauer, Delia S. |
| collection | DOAJ |
| description | Bioactive glasses were the first synthetic materials to bond to human body tissue, making them ideal for replacing and regenerating bone. Since their first development over half a century ago, many new bioactive glass compositions have been developed for medicine and dentistry. This paper looks at different design strategies employed over the years as well as aspects of glass structure relevant to optimising bioactive glass performance. Statistical compositional series allowed for getting an overview of various compositions and their properties. Since the improvement of structural analysis techniques, particularly solid-state NMR, we can directly relate several bioactive glass properties to the atomic structure, i.e. the spatial arrangement of atoms. Such detailed understanding of the impact of composition and structure on bioactive glass properties enables us to minimise the number of compositions in preclinical and clinical tests needed to confirm positive tissue responses. |
| first_indexed | 2024-03-10T07:22:47Z |
| format | Article |
| id | doaj.art-0047bc84ed8c4ee1b9fe2d4a16117bf4 |
| institution | Directory Open Access Journal |
| issn | 1778-7025 |
| language | English |
| last_indexed | 2024-03-10T07:22:47Z |
| publishDate | 2022-07-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus. Géoscience |
| spelling | doaj.art-0047bc84ed8c4ee1b9fe2d4a16117bf42023-11-22T14:29:14ZengAcadémie des sciencesComptes Rendus. Géoscience1778-70252022-07-01354S118519710.5802/crgeos.13410.5802/crgeos.134Glass as a biomaterial: strategies for optimising bioactive glasses for clinical applicationsBrauer, Delia S.0https://orcid.org/0000-0001-5062-0695Hupa, Leena1Otto Schott Institute of Materials Research, Friedrich Schiller University, Fraunhoferstr. 6, 07743 Jena, GermanyJohan Gadolin Process Chemistry Centre, Åbo Akademi University, Henrikinkatu 2, 20500 Turku, FinlandBioactive glasses were the first synthetic materials to bond to human body tissue, making them ideal for replacing and regenerating bone. Since their first development over half a century ago, many new bioactive glass compositions have been developed for medicine and dentistry. This paper looks at different design strategies employed over the years as well as aspects of glass structure relevant to optimising bioactive glass performance. Statistical compositional series allowed for getting an overview of various compositions and their properties. Since the improvement of structural analysis techniques, particularly solid-state NMR, we can directly relate several bioactive glass properties to the atomic structure, i.e. the spatial arrangement of atoms. Such detailed understanding of the impact of composition and structure on bioactive glass properties enables us to minimise the number of compositions in preclinical and clinical tests needed to confirm positive tissue responses.https://comptes-rendus.academie-sciences.fr/geoscience/articles/10.5802/crgeos.134/Bioactive glassesGlass structureBiomaterial developmentGlassProperty optimisationRegression analysis |
| spellingShingle | Brauer, Delia S. Hupa, Leena Glass as a biomaterial: strategies for optimising bioactive glasses for clinical applications Comptes Rendus. Géoscience Bioactive glasses Glass structure Biomaterial development Glass Property optimisation Regression analysis |
| title | Glass as a biomaterial: strategies for optimising bioactive glasses for clinical applications |
| title_full | Glass as a biomaterial: strategies for optimising bioactive glasses for clinical applications |
| title_fullStr | Glass as a biomaterial: strategies for optimising bioactive glasses for clinical applications |
| title_full_unstemmed | Glass as a biomaterial: strategies for optimising bioactive glasses for clinical applications |
| title_short | Glass as a biomaterial: strategies for optimising bioactive glasses for clinical applications |
| title_sort | glass as a biomaterial strategies for optimising bioactive glasses for clinical applications |
| topic | Bioactive glasses Glass structure Biomaterial development Glass Property optimisation Regression analysis |
| url | https://comptes-rendus.academie-sciences.fr/geoscience/articles/10.5802/crgeos.134/ |
| work_keys_str_mv | AT brauerdelias glassasabiomaterialstrategiesforoptimisingbioactiveglassesforclinicalapplications AT hupaleena glassasabiomaterialstrategiesforoptimisingbioactiveglassesforclinicalapplications |