Ten year real world experience with ultrafiltration for the management of acute decompensated heart failure
Background: Randomized controlled trials (RCT) of ultrafiltration (UF) have demonstrated conflicting results regarding its efficacy and safety. Objective: We reviewed 10 years of data for adjustable UF during heart failure hospitalizations in a real world cohort. Methods: We performed a retrospectiv...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-12-01
|
| Series: | American Heart Journal Plus |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666602222001471 |
| _version_ | 1811202142384422912 |
|---|---|
| author | Donald C. Haas Maureen Hummel Patricia Barrella Waqas Ullah Misung Yi Robert A. Watson, III |
| author_facet | Donald C. Haas Maureen Hummel Patricia Barrella Waqas Ullah Misung Yi Robert A. Watson, III |
| author_sort | Donald C. Haas |
| collection | DOAJ |
| description | Background: Randomized controlled trials (RCT) of ultrafiltration (UF) have demonstrated conflicting results regarding its efficacy and safety. Objective: We reviewed 10 years of data for adjustable UF during heart failure hospitalizations in a real world cohort. Methods: We performed a retrospective, single center analysis of 335 consecutive patients treated with adjustable rate UF using the CHF Solutions Aquadex Flex Flo System from 2009 to 2019. Results: Compared to previous RCTs investigating UF, our cohort was older, with worse renal impairment and more antecedent HF hospitalizations in the year preceding therapy. Mean fluid removal with UF was 14.6 l. Mean weight loss with UF was 15.6 lbs (range 0.2–57 lbs) and was sustained at 1–2 week follow-up. Mean creatinine change upon stopping UF, at discharge and follow-up (mean 30 days) was +0.11 mg/dl, +0.07 mg/dl and +0.11 mg/dl, respectively. HF rehospitalizations at 30 days, 90 days and 1 year were 12.4 %, 14.9 % and 27.3 % respectively. On average patients had 1.74 fewer hospitalizations for HF in the year following UF when compared to 12 months preceding UF. Major bleeding defined as requiring discontinuation of anticoagulation occurred in 3.6 % of patients. Conclusions: Compared with previous UF trials, our study demonstrates that UF compares favorably for HF rehospitalizations, renal function response, and weight/volume loss. Importantly, our real world experience allowed for the adjustment of UF rate during therapy and we believe this is a major contributor to our favorable outcomes. In clinical practice, UF can be a safe and effective strategy for decongestion. |
| first_indexed | 2024-04-12T02:34:56Z |
| format | Article |
| id | doaj.art-00495ad33d734066958bda223ad2d2a3 |
| institution | Directory Open Access Journal |
| issn | 2666-6022 |
| language | English |
| last_indexed | 2024-04-12T02:34:56Z |
| publishDate | 2022-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | American Heart Journal Plus |
| spelling | doaj.art-00495ad33d734066958bda223ad2d2a32022-12-22T03:51:36ZengElsevierAmerican Heart Journal Plus2666-60222022-12-0124100230Ten year real world experience with ultrafiltration for the management of acute decompensated heart failureDonald C. Haas0Maureen Hummel1Patricia Barrella2Waqas Ullah3Misung Yi4Robert A. Watson, III5Department of Cardiology, Jefferson Abington Hospital, Thomas Jefferson University Hospital, United States of America; Corresponding authors at: Comprehensive Heart Failure Program, Jefferson Health Abington, 1200 Old York Rd, 5 Toll, Abington, PA 19001, United States of America.Department of Cardiology, Jefferson Abington Hospital, Thomas Jefferson University Hospital, United States of AmericaDepartment of Cardiology, Jefferson Abington Hospital, Thomas Jefferson University Hospital, United States of America; Corresponding authors at: Comprehensive Heart Failure Program, Jefferson Health Abington, 1200 Old York Rd, 5 Toll, Abington, PA 19001, United States of America.Department of Cardiology, Thomas Jefferson Hospital, United States of AmericaThomas Jefferson Hospital, United States of AmericaDepartment of Cardiology, Jefferson Abington Hospital, Thomas Jefferson University Hospital, United States of AmericaBackground: Randomized controlled trials (RCT) of ultrafiltration (UF) have demonstrated conflicting results regarding its efficacy and safety. Objective: We reviewed 10 years of data for adjustable UF during heart failure hospitalizations in a real world cohort. Methods: We performed a retrospective, single center analysis of 335 consecutive patients treated with adjustable rate UF using the CHF Solutions Aquadex Flex Flo System from 2009 to 2019. Results: Compared to previous RCTs investigating UF, our cohort was older, with worse renal impairment and more antecedent HF hospitalizations in the year preceding therapy. Mean fluid removal with UF was 14.6 l. Mean weight loss with UF was 15.6 lbs (range 0.2–57 lbs) and was sustained at 1–2 week follow-up. Mean creatinine change upon stopping UF, at discharge and follow-up (mean 30 days) was +0.11 mg/dl, +0.07 mg/dl and +0.11 mg/dl, respectively. HF rehospitalizations at 30 days, 90 days and 1 year were 12.4 %, 14.9 % and 27.3 % respectively. On average patients had 1.74 fewer hospitalizations for HF in the year following UF when compared to 12 months preceding UF. Major bleeding defined as requiring discontinuation of anticoagulation occurred in 3.6 % of patients. Conclusions: Compared with previous UF trials, our study demonstrates that UF compares favorably for HF rehospitalizations, renal function response, and weight/volume loss. Importantly, our real world experience allowed for the adjustment of UF rate during therapy and we believe this is a major contributor to our favorable outcomes. In clinical practice, UF can be a safe and effective strategy for decongestion.http://www.sciencedirect.com/science/article/pii/S2666602222001471Heart failureUltrafiltrationAquapheresisDecongestion |
| spellingShingle | Donald C. Haas Maureen Hummel Patricia Barrella Waqas Ullah Misung Yi Robert A. Watson, III Ten year real world experience with ultrafiltration for the management of acute decompensated heart failure American Heart Journal Plus Heart failure Ultrafiltration Aquapheresis Decongestion |
| title | Ten year real world experience with ultrafiltration for the management of acute decompensated heart failure |
| title_full | Ten year real world experience with ultrafiltration for the management of acute decompensated heart failure |
| title_fullStr | Ten year real world experience with ultrafiltration for the management of acute decompensated heart failure |
| title_full_unstemmed | Ten year real world experience with ultrafiltration for the management of acute decompensated heart failure |
| title_short | Ten year real world experience with ultrafiltration for the management of acute decompensated heart failure |
| title_sort | ten year real world experience with ultrafiltration for the management of acute decompensated heart failure |
| topic | Heart failure Ultrafiltration Aquapheresis Decongestion |
| url | http://www.sciencedirect.com/science/article/pii/S2666602222001471 |
| work_keys_str_mv | AT donaldchaas tenyearrealworldexperiencewithultrafiltrationforthemanagementofacutedecompensatedheartfailure AT maureenhummel tenyearrealworldexperiencewithultrafiltrationforthemanagementofacutedecompensatedheartfailure AT patriciabarrella tenyearrealworldexperiencewithultrafiltrationforthemanagementofacutedecompensatedheartfailure AT waqasullah tenyearrealworldexperiencewithultrafiltrationforthemanagementofacutedecompensatedheartfailure AT misungyi tenyearrealworldexperiencewithultrafiltrationforthemanagementofacutedecompensatedheartfailure AT robertawatsoniii tenyearrealworldexperiencewithultrafiltrationforthemanagementofacutedecompensatedheartfailure |