Differential effects of aquaporin-4 channel inhibition on BOLD fMRI and diffusion fMRI responses in mouse visual cortex.
The contribution of astrocytes to the BOLD fMRI and DfMRI responses in visual cortex of mice following visual stimulation was investigated using TGN-020, an aquaporin 4 (AQP4) channel blocker, acting as an astrocyte function perturbator. Under TGN-020 injection the amplitude of the BOLD fMRI respons...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2020-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0228759 |
| _version_ | 1829498343479312384 |
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| author | Yuji Komaki Clement Debacker Boucif Djemai Luisa Ciobanu Tomokazu Tsurugizawa Denis Le Bihan |
| author_facet | Yuji Komaki Clement Debacker Boucif Djemai Luisa Ciobanu Tomokazu Tsurugizawa Denis Le Bihan |
| author_sort | Yuji Komaki |
| collection | DOAJ |
| description | The contribution of astrocytes to the BOLD fMRI and DfMRI responses in visual cortex of mice following visual stimulation was investigated using TGN-020, an aquaporin 4 (AQP4) channel blocker, acting as an astrocyte function perturbator. Under TGN-020 injection the amplitude of the BOLD fMRI response became significantly higher. In contrast no significant changes in the DfMRI responses and the electrophysiological responses were observed. Those results further confirm the implications of astrocytes in the neurovascular coupling mechanism underlying BOLD fMRI, but not in the DfMRI responses which remained unsensitive to astrocyte function perturbation. |
| first_indexed | 2024-12-16T08:10:42Z |
| format | Article |
| id | doaj.art-004a702459d94505ac86292911835a46 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-16T08:10:42Z |
| publishDate | 2020-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-004a702459d94505ac86292911835a462022-12-21T22:38:20ZengPublic Library of Science (PLoS)PLoS ONE1932-62032020-01-01155e022875910.1371/journal.pone.0228759Differential effects of aquaporin-4 channel inhibition on BOLD fMRI and diffusion fMRI responses in mouse visual cortex.Yuji KomakiClement DebackerBoucif DjemaiLuisa CiobanuTomokazu TsurugizawaDenis Le BihanThe contribution of astrocytes to the BOLD fMRI and DfMRI responses in visual cortex of mice following visual stimulation was investigated using TGN-020, an aquaporin 4 (AQP4) channel blocker, acting as an astrocyte function perturbator. Under TGN-020 injection the amplitude of the BOLD fMRI response became significantly higher. In contrast no significant changes in the DfMRI responses and the electrophysiological responses were observed. Those results further confirm the implications of astrocytes in the neurovascular coupling mechanism underlying BOLD fMRI, but not in the DfMRI responses which remained unsensitive to astrocyte function perturbation.https://doi.org/10.1371/journal.pone.0228759 |
| spellingShingle | Yuji Komaki Clement Debacker Boucif Djemai Luisa Ciobanu Tomokazu Tsurugizawa Denis Le Bihan Differential effects of aquaporin-4 channel inhibition on BOLD fMRI and diffusion fMRI responses in mouse visual cortex. PLoS ONE |
| title | Differential effects of aquaporin-4 channel inhibition on BOLD fMRI and diffusion fMRI responses in mouse visual cortex. |
| title_full | Differential effects of aquaporin-4 channel inhibition on BOLD fMRI and diffusion fMRI responses in mouse visual cortex. |
| title_fullStr | Differential effects of aquaporin-4 channel inhibition on BOLD fMRI and diffusion fMRI responses in mouse visual cortex. |
| title_full_unstemmed | Differential effects of aquaporin-4 channel inhibition on BOLD fMRI and diffusion fMRI responses in mouse visual cortex. |
| title_short | Differential effects of aquaporin-4 channel inhibition on BOLD fMRI and diffusion fMRI responses in mouse visual cortex. |
| title_sort | differential effects of aquaporin 4 channel inhibition on bold fmri and diffusion fmri responses in mouse visual cortex |
| url | https://doi.org/10.1371/journal.pone.0228759 |
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