NEP1-40-modified human serum albumin nanoparticles enhance the therapeutic effect of methylprednisolone against spinal cord injury

NEP1-40-modified human serum albumin nanoparticles enhance the therapeutic effect of methylprednisolone against spinal cord injury

Abstract Background Frequent injection of high-dose methylprednisolone (MP) is used to treat spinal cord injury (SCI), but free MP is associated with various side effects and its water solubility is low, limiting potential dosing regimes and administration routes. Albumin-based nanoparticles, which...

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Bibliographic Details
Main Authors: Yan Lin, Chunhong Li, Jian Li, Ruolan Deng, Juan Huang, Qinglian Zhang, Jiayao Lyu, Na Hao, Zhirong Zhong
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Journal of Nanobiotechnology
Subjects:
NEP1-40
Human serum albumin nanoparticles
Methylprednisolone
Spinal cord injury
Online Access:http://link.springer.com/article/10.1186/s12951-019-0449-3

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http://link.springer.com/article/10.1186/s12951-019-0449-3

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