Perinatal characteristics and longer-term outcomes in Brazilian children with confirmed or suspected congenital Zika infection: ZIKAction Paediatric Registry
Background: Despite growing scientific knowledge of Zika virus (ZIKV) infection, questions remain regarding ZIKV infection in pregnancy and congenital ZIKV syndrome (CZS). Methods: The ZIKAction Paediatric Registry is an international registry of children with documented ZIKV exposure in utero and/o...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Dialogues in Health |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772653323000084 |
| _version_ | 1797796229479923712 |
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| author | Isadora Cristina de Siqueira Breno Lima de Almeida Maria Lucia Costa Lage Leticia Serra Alessandra Carvalho Maricélia Maia de Lima Maria de Fatima Neri Góes Marília De Santa Inês Neri Crispim Mirela Monteiro da Costa Pereira Bernardo Gratival Gouvea Costa Heather Bailey Thomas Byrne Carlo Giaquinto Georgina Fernandes Elisa Ruiz-Burga Claire Thorne |
| author_facet | Isadora Cristina de Siqueira Breno Lima de Almeida Maria Lucia Costa Lage Leticia Serra Alessandra Carvalho Maricélia Maia de Lima Maria de Fatima Neri Góes Marília De Santa Inês Neri Crispim Mirela Monteiro da Costa Pereira Bernardo Gratival Gouvea Costa Heather Bailey Thomas Byrne Carlo Giaquinto Georgina Fernandes Elisa Ruiz-Burga Claire Thorne |
| author_sort | Isadora Cristina de Siqueira |
| collection | DOAJ |
| description | Background: Despite growing scientific knowledge of Zika virus (ZIKV) infection, questions remain regarding ZIKV infection in pregnancy and congenital ZIKV syndrome (CZS). Methods: The ZIKAction Paediatric Registry is an international registry of children with documented ZIKV exposure in utero and/or with confirmed or suspected CZS. Its aim is to characterize these children (i.e., clinical, radiological, neurodevelopmental features) and describe outcomes, longer-term sequelae and management through retrospective case note review. This analysis described the maternal and perinatal characteristics of children in the Registry’s Bahia arm, assessed their neuroimaging, ophthalmic, hearing and electroencephalography abnormalities by microcephaly classification and reported on hospitalisations. Children born in 2015-2018 and enrolled 2020-2021 in three public health facilities in Salvador were included. Results: Of 129 (57% female) children, 15 (11·6%) had laboratory-confirmed congenital ZIKV infection and 114 (88·4%) suspected CZS. At delivery, 15 (11·6%) were normocephalic, 30 (23·3%) moderately microcephalic, and 84 (65·1%) severely microcephalic. Median birth head circumference z-score was -3·51 [IQR, -4·69,-2·73]. During follow-up, all children had abnormal neuroimaging, 80·3% (94/117) abnormal electroencephalogram, 62·2% (77/120) ophthalmic abnormalities, and 27·4% (34/124) hearing impairment. Microcephaly classification was significantly associated with gestational age, and ophthalmological and electroencephalography abnormalities. Of 125 children with hospitalisation data, 52 (41·6%) had been hospitalised by most recent follow-up, at median age of 15·8 [4·0, 34·4] months; infections were the leading cause. Conclusion: Congenital ZIKV infection is an emerging disease with a varied and incompletely understood spectrum. Continued long-term follow-up is essential to understand longer-term prognosis and to inform future health and educational needs. |
| first_indexed | 2024-03-13T03:30:57Z |
| format | Article |
| id | doaj.art-004eb2150dd84db494e5f2a121c05da3 |
| institution | Directory Open Access Journal |
| issn | 2772-6533 |
| language | English |
| last_indexed | 2024-03-13T03:30:57Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Dialogues in Health |
| spelling | doaj.art-004eb2150dd84db494e5f2a121c05da32023-06-24T05:20:10ZengElsevierDialogues in Health2772-65332023-12-012100104Perinatal characteristics and longer-term outcomes in Brazilian children with confirmed or suspected congenital Zika infection: ZIKAction Paediatric RegistryIsadora Cristina de Siqueira0Breno Lima de Almeida1Maria Lucia Costa Lage2Leticia Serra3Alessandra Carvalho4Maricélia Maia de Lima5Maria de Fatima Neri Góes6Marília De Santa Inês Neri Crispim7Mirela Monteiro da Costa Pereira8Bernardo Gratival Gouvea Costa9Heather Bailey10Thomas Byrne11Carlo Giaquinto12Georgina Fernandes13Elisa Ruiz-Burga14Claire Thorne15Instituto Gonçalo Moniz-Fiocruz, Rua Waldemar Falcão, 121, Candeal, Salvador, BA, BrazilInstituto Gonçalo Moniz-Fiocruz, Rua Waldemar Falcão, 121, Candeal, Salvador, BA, BrazilInstituto Gonçalo Moniz-Fiocruz, Rua Waldemar Falcão, 121, Candeal, Salvador, BA, BrazilCentro de Prevenção e Reabilitação da Pessoa com Deficiência – Cepred, Av. Antônio Carlos Magalhães, S/N, Parque Bela Vista, 40279-700 Salvador, BA, BrazilRede SARAH de Hospitais de Reabilitação, Av. Tancredo Neves, 2782 - Caminho das Árvores, 41820-900 Salvador, BA, BrazilUniversidade Estadual de Feira de Santana, Avenida Transnordestina, s/n - Novo Horizonte, 44036-900 Feira de Santana, BA, BrazilInstituto Cegos da Bahia, R. São José de Baixo - Barbalho, 40300-770 Salvador, BA, BrazilInstituto Cegos da Bahia, R. São José de Baixo - Barbalho, 40300-770 Salvador, BA, BrazilInstituto Gonçalo Moniz-Fiocruz, Rua Waldemar Falcão, 121, Candeal, Salvador, BA, BrazilInstituto Gonçalo Moniz-Fiocruz, Rua Waldemar Falcão, 121, Candeal, Salvador, BA, BrazilUCL Institute for Global Health, University College London, Mortimer Market Centre, Capper street, London WC1 6JB, UKUCL Great Ormond Street Institute of Child Health, GOSH NIHR BRC, 30 Guilford Street, London WC1N 1EH, UKDivision of Paediatric Infectious Diseases, Department for Woman and Child Health, University of Padova, Via Giustiniani 3, 35128 Padova, ItalyUCL Great Ormond Street Institute of Child Health, GOSH NIHR BRC, 30 Guilford Street, London WC1N 1EH, UKUCL Institute for Global Health, University College London, Mortimer Market Centre, Capper street, London WC1 6JB, UK; UCL Great Ormond Street Institute of Child Health, GOSH NIHR BRC, 30 Guilford Street, London WC1N 1EH, UKUCL Great Ormond Street Institute of Child Health, GOSH NIHR BRC, 30 Guilford Street, London WC1N 1EH, UK; Corresponding author.Background: Despite growing scientific knowledge of Zika virus (ZIKV) infection, questions remain regarding ZIKV infection in pregnancy and congenital ZIKV syndrome (CZS). Methods: The ZIKAction Paediatric Registry is an international registry of children with documented ZIKV exposure in utero and/or with confirmed or suspected CZS. Its aim is to characterize these children (i.e., clinical, radiological, neurodevelopmental features) and describe outcomes, longer-term sequelae and management through retrospective case note review. This analysis described the maternal and perinatal characteristics of children in the Registry’s Bahia arm, assessed their neuroimaging, ophthalmic, hearing and electroencephalography abnormalities by microcephaly classification and reported on hospitalisations. Children born in 2015-2018 and enrolled 2020-2021 in three public health facilities in Salvador were included. Results: Of 129 (57% female) children, 15 (11·6%) had laboratory-confirmed congenital ZIKV infection and 114 (88·4%) suspected CZS. At delivery, 15 (11·6%) were normocephalic, 30 (23·3%) moderately microcephalic, and 84 (65·1%) severely microcephalic. Median birth head circumference z-score was -3·51 [IQR, -4·69,-2·73]. During follow-up, all children had abnormal neuroimaging, 80·3% (94/117) abnormal electroencephalogram, 62·2% (77/120) ophthalmic abnormalities, and 27·4% (34/124) hearing impairment. Microcephaly classification was significantly associated with gestational age, and ophthalmological and electroencephalography abnormalities. Of 125 children with hospitalisation data, 52 (41·6%) had been hospitalised by most recent follow-up, at median age of 15·8 [4·0, 34·4] months; infections were the leading cause. Conclusion: Congenital ZIKV infection is an emerging disease with a varied and incompletely understood spectrum. Continued long-term follow-up is essential to understand longer-term prognosis and to inform future health and educational needs.http://www.sciencedirect.com/science/article/pii/S2772653323000084Congenital Zika SyndromeMicrocephalyNeurodevelopmentZika Virus |
| spellingShingle | Isadora Cristina de Siqueira Breno Lima de Almeida Maria Lucia Costa Lage Leticia Serra Alessandra Carvalho Maricélia Maia de Lima Maria de Fatima Neri Góes Marília De Santa Inês Neri Crispim Mirela Monteiro da Costa Pereira Bernardo Gratival Gouvea Costa Heather Bailey Thomas Byrne Carlo Giaquinto Georgina Fernandes Elisa Ruiz-Burga Claire Thorne Perinatal characteristics and longer-term outcomes in Brazilian children with confirmed or suspected congenital Zika infection: ZIKAction Paediatric Registry Dialogues in Health Congenital Zika Syndrome Microcephaly Neurodevelopment Zika Virus |
| title | Perinatal characteristics and longer-term outcomes in Brazilian children with confirmed or suspected congenital Zika infection: ZIKAction Paediatric Registry |
| title_full | Perinatal characteristics and longer-term outcomes in Brazilian children with confirmed or suspected congenital Zika infection: ZIKAction Paediatric Registry |
| title_fullStr | Perinatal characteristics and longer-term outcomes in Brazilian children with confirmed or suspected congenital Zika infection: ZIKAction Paediatric Registry |
| title_full_unstemmed | Perinatal characteristics and longer-term outcomes in Brazilian children with confirmed or suspected congenital Zika infection: ZIKAction Paediatric Registry |
| title_short | Perinatal characteristics and longer-term outcomes in Brazilian children with confirmed or suspected congenital Zika infection: ZIKAction Paediatric Registry |
| title_sort | perinatal characteristics and longer term outcomes in brazilian children with confirmed or suspected congenital zika infection zikaction paediatric registry |
| topic | Congenital Zika Syndrome Microcephaly Neurodevelopment Zika Virus |
| url | http://www.sciencedirect.com/science/article/pii/S2772653323000084 |
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