Different TP53 mutants in p53 overexpressed epithelial ovarian carcinoma can be associated both with altered and unaltered glycolytic and apoptotic profiles

Different TP53 mutants in p53 overexpressed epithelial ovarian carcinoma can be associated both with altered and unaltered glycolytic and apoptotic profiles

Abstract Background p53 is a tumor suppressor and key regulator of glycolysis in cancer cells, however highly mutated in tumors. In ovarian cancer, studies concerning p53 mutations focus on the DNA binding domain since the majority of hotspot mutations affects this region. Yet, mutations in other re...

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Bibliographic Details
Main Authors: Stephanie Antoun, David Atallah, Roula Tahtouh, Nada Alaaeddine, Malak Moubarak, Abir Khaddage, Eliane Nasr Ayoub, George Chahine, George Hilal
Format: Article
Language:English
Published: BMC 2018-01-01
Series:Cancer Cell International
Subjects:
Apoptosis
Glucose metabolism
Mutation
p53 overexpression
Ovarian cancer
Online Access:http://link.springer.com/article/10.1186/s12935-018-0514-2

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