Serotypes With Low Invasive Potential Are Associated With an Impaired Antibody Response in Invasive Pneumococcal Disease
Pneumococcal polysaccharide vaccines may elicit a hyporesponse under certain conditions. There is limited knowledge, however, on the type of specific antibody response in individuals with invasive pneumococcal disease (IPD). The aim of this study was to investigate the functional antibody response i...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-11-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fmicb.2018.02746/full |
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| author | Nils Littorin Fabian Uddén Jonas Ahl Jonas Ahl Fredrik Resman Fredrik Resman Hans-Christian Slotved Simon Athlin Kristian Riesbeck |
| author_facet | Nils Littorin Fabian Uddén Jonas Ahl Jonas Ahl Fredrik Resman Fredrik Resman Hans-Christian Slotved Simon Athlin Kristian Riesbeck |
| author_sort | Nils Littorin |
| collection | DOAJ |
| description | Pneumococcal polysaccharide vaccines may elicit a hyporesponse under certain conditions. There is limited knowledge, however, on the type of specific antibody response in individuals with invasive pneumococcal disease (IPD). The aim of this study was to investigate the functional antibody response in patients with IPD caused by different serotypes. Pre-immune and convalescent sera from 40 patients (age 14–91 years) with IPD caused by serotypes with low (serotype 3, 19F, and 23F) and high (1, 4, 7F, and 14) invasive potential were investigated. For each patient, the homologous serotype-specific antibody concentration was determined. The functionality of induced antibodies post-IPD was evaluated in an opsonophagocytic assay (OPA). Undetectable or decreased pneumococcal killing in OPA following IPD, i.e., a nonfunctional antibody response, was observed in 24 of 40 patients (60%). Patients with nonfunctional antibody responses had lower serotype specific IgG antibody ratios post-IPD than patients with increased OPA titres. A nonfunctional antibody response was associated with low invasive serotypes (3, 19F, and 23F, p = 0.015). In conclusion, a nonfunctional antibody response may follow IPD, and was in our cohort associated to serotypes with low invasive potential. These findings need to be confirmed in a larger material. |
| first_indexed | 2024-12-18T21:41:30Z |
| format | Article |
| id | doaj.art-0055ab9ccaa746e99eb975961879efff |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-18T21:41:30Z |
| publishDate | 2018-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-0055ab9ccaa746e99eb975961879efff2022-12-21T20:50:47ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2018-11-01910.3389/fmicb.2018.02746420017Serotypes With Low Invasive Potential Are Associated With an Impaired Antibody Response in Invasive Pneumococcal DiseaseNils Littorin0Fabian Uddén1Jonas Ahl2Jonas Ahl3Fredrik Resman4Fredrik Resman5Hans-Christian Slotved6Simon Athlin7Kristian Riesbeck8Clinical Microbiology, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, SwedenClinical Microbiology, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, SwedenClinical Microbiology, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, SwedenInfectious Diseases, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, SwedenClinical Microbiology, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, SwedenInfectious Diseases, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, SwedenDepartment of Bacteria, Parasites and Fungi, Statens Serum Institut, Copenhagen, DenmarkDepartment of Infectious Diseases, Faculty of Medicine and Health, Örebro University, Örebro, SwedenClinical Microbiology, Department of Translational Medicine, Faculty of Medicine, Lund University, Malmö, SwedenPneumococcal polysaccharide vaccines may elicit a hyporesponse under certain conditions. There is limited knowledge, however, on the type of specific antibody response in individuals with invasive pneumococcal disease (IPD). The aim of this study was to investigate the functional antibody response in patients with IPD caused by different serotypes. Pre-immune and convalescent sera from 40 patients (age 14–91 years) with IPD caused by serotypes with low (serotype 3, 19F, and 23F) and high (1, 4, 7F, and 14) invasive potential were investigated. For each patient, the homologous serotype-specific antibody concentration was determined. The functionality of induced antibodies post-IPD was evaluated in an opsonophagocytic assay (OPA). Undetectable or decreased pneumococcal killing in OPA following IPD, i.e., a nonfunctional antibody response, was observed in 24 of 40 patients (60%). Patients with nonfunctional antibody responses had lower serotype specific IgG antibody ratios post-IPD than patients with increased OPA titres. A nonfunctional antibody response was associated with low invasive serotypes (3, 19F, and 23F, p = 0.015). In conclusion, a nonfunctional antibody response may follow IPD, and was in our cohort associated to serotypes with low invasive potential. These findings need to be confirmed in a larger material.https://www.frontiersin.org/article/10.3389/fmicb.2018.02746/fullantibodyopsonizationsepsisserotypeStreptococcus pneumoniae |
| spellingShingle | Nils Littorin Fabian Uddén Jonas Ahl Jonas Ahl Fredrik Resman Fredrik Resman Hans-Christian Slotved Simon Athlin Kristian Riesbeck Serotypes With Low Invasive Potential Are Associated With an Impaired Antibody Response in Invasive Pneumococcal Disease Frontiers in Microbiology antibody opsonization sepsis serotype Streptococcus pneumoniae |
| title | Serotypes With Low Invasive Potential Are Associated With an Impaired Antibody Response in Invasive Pneumococcal Disease |
| title_full | Serotypes With Low Invasive Potential Are Associated With an Impaired Antibody Response in Invasive Pneumococcal Disease |
| title_fullStr | Serotypes With Low Invasive Potential Are Associated With an Impaired Antibody Response in Invasive Pneumococcal Disease |
| title_full_unstemmed | Serotypes With Low Invasive Potential Are Associated With an Impaired Antibody Response in Invasive Pneumococcal Disease |
| title_short | Serotypes With Low Invasive Potential Are Associated With an Impaired Antibody Response in Invasive Pneumococcal Disease |
| title_sort | serotypes with low invasive potential are associated with an impaired antibody response in invasive pneumococcal disease |
| topic | antibody opsonization sepsis serotype Streptococcus pneumoniae |
| url | https://www.frontiersin.org/article/10.3389/fmicb.2018.02746/full |
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