Effects of Sucrose Palmitate on the Physico-Chemical and Mucoadhesive Properties of Buccal Films
In our current research, sucrose palmitate (SP) was applied as a possible permeation enhancer for buccal use. This route of administration is a novelty as there is no literature on the use of SP in buccal mucoadhesive films. Films containing SP were prepared at different temperatures, with different...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-11-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/22/5248 |
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| author | András Kelemen Bálint Katona Szilvia Módra Zoltán Aigner István Sebe Klára Pintye-Hódi Romána Zelkó Géza Regdon Katalin Kristó |
| author_facet | András Kelemen Bálint Katona Szilvia Módra Zoltán Aigner István Sebe Klára Pintye-Hódi Romána Zelkó Géza Regdon Katalin Kristó |
| author_sort | András Kelemen |
| collection | DOAJ |
| description | In our current research, sucrose palmitate (SP) was applied as a possible permeation enhancer for buccal use. This route of administration is a novelty as there is no literature on the use of SP in buccal mucoadhesive films. Films containing SP were prepared at different temperatures, with different concentrations of SP and different lengths of hydroxypropyl methylcellulose (HPMC) chains. The mechanical, structural, and in vitro mucoadhesive properties of films containing SP were investigated. Tensile strength and mucoadhesive force were measured with a device and software developed in our Institute. Positron annihilation lifetime spectroscopy (PALS) and X-ray powder diffractometry (XRPD) were applied for the structure analysis of the films. Mucoadhesive work was calculated in two ways: from the measured contact angle and compared with direct mucoadhesive work, which measured mucoadhesive force, which is direct mucoadhesion work. These results correlate linearly with a correlation coefficient of 0.98. It is also novel because it is a new method for the determination of mucoadhesive work. |
| first_indexed | 2024-03-10T14:56:30Z |
| format | Article |
| id | doaj.art-00575f8e741b470f9594fa4f5278f2b1 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T14:56:30Z |
| publishDate | 2020-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-00575f8e741b470f9594fa4f5278f2b12023-11-20T20:31:58ZengMDPI AGMolecules1420-30492020-11-012522524810.3390/molecules25225248Effects of Sucrose Palmitate on the Physico-Chemical and Mucoadhesive Properties of Buccal FilmsAndrás Kelemen0Bálint Katona1Szilvia Módra2Zoltán Aigner3István Sebe4Klára Pintye-Hódi5Romána Zelkó6Géza Regdon7Katalin Kristó8Department of Applied Informatics, University of Szeged, Boldogasszony sgt. 6., H-6725 Szeged, HungaryInstitute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u. 6., H-6720 Szeged, HungaryInstitute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u. 6., H-6720 Szeged, HungaryInstitute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u. 6., H-6720 Szeged, HungaryUniversity Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes E. u. 7-9., H-1092 Budapest, HungaryInstitute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u. 6., H-6720 Szeged, HungaryUniversity Pharmacy Department of Pharmacy Administration, Semmelweis University, Hőgyes E. u. 7-9., H-1092 Budapest, HungaryInstitute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u. 6., H-6720 Szeged, HungaryInstitute of Pharmaceutical Technology and Regulatory Affairs, University of Szeged, Eötvös u. 6., H-6720 Szeged, HungaryIn our current research, sucrose palmitate (SP) was applied as a possible permeation enhancer for buccal use. This route of administration is a novelty as there is no literature on the use of SP in buccal mucoadhesive films. Films containing SP were prepared at different temperatures, with different concentrations of SP and different lengths of hydroxypropyl methylcellulose (HPMC) chains. The mechanical, structural, and in vitro mucoadhesive properties of films containing SP were investigated. Tensile strength and mucoadhesive force were measured with a device and software developed in our Institute. Positron annihilation lifetime spectroscopy (PALS) and X-ray powder diffractometry (XRPD) were applied for the structure analysis of the films. Mucoadhesive work was calculated in two ways: from the measured contact angle and compared with direct mucoadhesive work, which measured mucoadhesive force, which is direct mucoadhesion work. These results correlate linearly with a correlation coefficient of 0.98. It is also novel because it is a new method for the determination of mucoadhesive work.https://www.mdpi.com/1420-3049/25/22/5248mucoadhesionbuccal filmmucoadhesive worksucrose-palmitate |
| spellingShingle | András Kelemen Bálint Katona Szilvia Módra Zoltán Aigner István Sebe Klára Pintye-Hódi Romána Zelkó Géza Regdon Katalin Kristó Effects of Sucrose Palmitate on the Physico-Chemical and Mucoadhesive Properties of Buccal Films Molecules mucoadhesion buccal film mucoadhesive work sucrose-palmitate |
| title | Effects of Sucrose Palmitate on the Physico-Chemical and Mucoadhesive Properties of Buccal Films |
| title_full | Effects of Sucrose Palmitate on the Physico-Chemical and Mucoadhesive Properties of Buccal Films |
| title_fullStr | Effects of Sucrose Palmitate on the Physico-Chemical and Mucoadhesive Properties of Buccal Films |
| title_full_unstemmed | Effects of Sucrose Palmitate on the Physico-Chemical and Mucoadhesive Properties of Buccal Films |
| title_short | Effects of Sucrose Palmitate on the Physico-Chemical and Mucoadhesive Properties of Buccal Films |
| title_sort | effects of sucrose palmitate on the physico chemical and mucoadhesive properties of buccal films |
| topic | mucoadhesion buccal film mucoadhesive work sucrose-palmitate |
| url | https://www.mdpi.com/1420-3049/25/22/5248 |
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