The Acute Effect of Hydroxychloroquine Sulfate on Hunger, the Plasma Concentration of Orexigenic Peptides and Hedonic Food Intake: A Pilot Study
The direct infusion of bitter solutions in the gastrointestinal tract can reduce the secretion of orexigenic hormones and influence appetite and food intake. We aimed to explore whether oral ingestion of the bitter tastant hydroxychloroquine sulfate can exert similar effects. Ten lean adult women we...
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MDPI AG
2023-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/15/19/4264 |
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| author | Emily Ruilova Sosoranga Wout Verbeure Hannelore Geysen Theo Thijs Christophe Matthys Inge Depoortere Jan Tack |
| author_facet | Emily Ruilova Sosoranga Wout Verbeure Hannelore Geysen Theo Thijs Christophe Matthys Inge Depoortere Jan Tack |
| author_sort | Emily Ruilova Sosoranga |
| collection | DOAJ |
| description | The direct infusion of bitter solutions in the gastrointestinal tract can reduce the secretion of orexigenic hormones and influence appetite and food intake. We aimed to explore whether oral ingestion of the bitter tastant hydroxychloroquine sulfate can exert similar effects. Ten lean adult women were included in this double-blind, randomized, two-visit, crossover study. After an overnight fast, each volunteer received film-coated tablets containing 400 mg of hydroxychloroquine sulfate (Plaquenil<sup>®</sup>) or placebo. Plasma-ghrelin, -motilin, -insulin and blood-glucose concentrations were determined every 10 min before and 30 min after feeding; appetite was scored every 10 min. Hunger scores were investigated with a special interest 50–60 min after the ingestion of hydroxychloroquine sulfate, right before a rewarding chocolate milkshake was offered to drink ad libitum. Compared with the placebo, hydroxychloroquine sulfate tended to reduce hunger at the time of interest (<i>p</i> = 0.10). No effect was found upon subsequent milkshake intake. Motilin plasma concentrations were unaltered, but acyl-ghrelin plasma concentrations decreased after the ingestion of hydroxychloroquine sulfate (t = 40–50; <i>p</i> < 0.05). These data suggest that the oral intake of hydroxychloroquine sulfate tablets reduces subjective hunger via a ghrelin-dependent mechanism but does not affect motilin release, hedonic food intake or insulin levels in healthy women. |
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| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T21:37:21Z |
| publishDate | 2023-10-01 |
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| series | Nutrients |
| spelling | doaj.art-00579ecb8a4747d382facc1e6bbb5f1c2023-11-19T14:52:29ZengMDPI AGNutrients2072-66432023-10-011519426410.3390/nu15194264The Acute Effect of Hydroxychloroquine Sulfate on Hunger, the Plasma Concentration of Orexigenic Peptides and Hedonic Food Intake: A Pilot StudyEmily Ruilova Sosoranga0Wout Verbeure1Hannelore Geysen2Theo Thijs3Christophe Matthys4Inge Depoortere5Jan Tack6Translational Research Center for Gastrointestinal Disorders, KU Leuven, 3000 Leuven, BelgiumTranslational Research Center for Gastrointestinal Disorders, KU Leuven, 3000 Leuven, BelgiumTranslational Research Center for Gastrointestinal Disorders, KU Leuven, 3000 Leuven, BelgiumTranslational Research Center for Gastrointestinal Disorders, KU Leuven, 3000 Leuven, BelgiumClinical and Experimental Endocrinology, KU Leuven, 3000 Leuven, BelgiumTranslational Research Center for Gastrointestinal Disorders, KU Leuven, 3000 Leuven, BelgiumTranslational Research Center for Gastrointestinal Disorders, KU Leuven, 3000 Leuven, BelgiumThe direct infusion of bitter solutions in the gastrointestinal tract can reduce the secretion of orexigenic hormones and influence appetite and food intake. We aimed to explore whether oral ingestion of the bitter tastant hydroxychloroquine sulfate can exert similar effects. Ten lean adult women were included in this double-blind, randomized, two-visit, crossover study. After an overnight fast, each volunteer received film-coated tablets containing 400 mg of hydroxychloroquine sulfate (Plaquenil<sup>®</sup>) or placebo. Plasma-ghrelin, -motilin, -insulin and blood-glucose concentrations were determined every 10 min before and 30 min after feeding; appetite was scored every 10 min. Hunger scores were investigated with a special interest 50–60 min after the ingestion of hydroxychloroquine sulfate, right before a rewarding chocolate milkshake was offered to drink ad libitum. Compared with the placebo, hydroxychloroquine sulfate tended to reduce hunger at the time of interest (<i>p</i> = 0.10). No effect was found upon subsequent milkshake intake. Motilin plasma concentrations were unaltered, but acyl-ghrelin plasma concentrations decreased after the ingestion of hydroxychloroquine sulfate (t = 40–50; <i>p</i> < 0.05). These data suggest that the oral intake of hydroxychloroquine sulfate tablets reduces subjective hunger via a ghrelin-dependent mechanism but does not affect motilin release, hedonic food intake or insulin levels in healthy women.https://www.mdpi.com/2072-6643/15/19/4264bitterappetiteghrelinmotilinfastingPlaquenil<sup>®</sup> |
| spellingShingle | Emily Ruilova Sosoranga Wout Verbeure Hannelore Geysen Theo Thijs Christophe Matthys Inge Depoortere Jan Tack The Acute Effect of Hydroxychloroquine Sulfate on Hunger, the Plasma Concentration of Orexigenic Peptides and Hedonic Food Intake: A Pilot Study Nutrients bitter appetite ghrelin motilin fasting Plaquenil<sup>®</sup> |
| title | The Acute Effect of Hydroxychloroquine Sulfate on Hunger, the Plasma Concentration of Orexigenic Peptides and Hedonic Food Intake: A Pilot Study |
| title_full | The Acute Effect of Hydroxychloroquine Sulfate on Hunger, the Plasma Concentration of Orexigenic Peptides and Hedonic Food Intake: A Pilot Study |
| title_fullStr | The Acute Effect of Hydroxychloroquine Sulfate on Hunger, the Plasma Concentration of Orexigenic Peptides and Hedonic Food Intake: A Pilot Study |
| title_full_unstemmed | The Acute Effect of Hydroxychloroquine Sulfate on Hunger, the Plasma Concentration of Orexigenic Peptides and Hedonic Food Intake: A Pilot Study |
| title_short | The Acute Effect of Hydroxychloroquine Sulfate on Hunger, the Plasma Concentration of Orexigenic Peptides and Hedonic Food Intake: A Pilot Study |
| title_sort | acute effect of hydroxychloroquine sulfate on hunger the plasma concentration of orexigenic peptides and hedonic food intake a pilot study |
| topic | bitter appetite ghrelin motilin fasting Plaquenil<sup>®</sup> |
| url | https://www.mdpi.com/2072-6643/15/19/4264 |
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