<em>KIF6</em> Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection
Background: KIF6 (kinesin family member 6), a protein coded by the <i>KIF6</i> gene, serves an important intracellular function to transport organelles along microtubules. In a pilot study, we found that a common <i>KIF6</i> Trp719Arg variant increased the propensity of thora...
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MDPI AG
2023-01-01
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| Online Access: | https://www.mdpi.com/2073-4425/14/2/252 |
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| author | Juan J. Velasco Yupeng Li Bulat A. Ziganshin Mohammad A. Zafar John A. Rizzo Deqiong Ma Hui Zang Asanish Kalyanasundaram John A. Elefteriades |
| author_facet | Juan J. Velasco Yupeng Li Bulat A. Ziganshin Mohammad A. Zafar John A. Rizzo Deqiong Ma Hui Zang Asanish Kalyanasundaram John A. Elefteriades |
| author_sort | Juan J. Velasco |
| collection | DOAJ |
| description | Background: KIF6 (kinesin family member 6), a protein coded by the <i>KIF6</i> gene, serves an important intracellular function to transport organelles along microtubules. In a pilot study, we found that a common <i>KIF6</i> Trp719Arg variant increased the propensity of thoracic aortic aneurysms (TAA) to suffer dissection (AD). The present study aims for a definite investigation of the predictive ability of <i>KIF6</i> 719Arg vis à vis AD. Confirmatory findings would enhance natural history prediction in TAA. Methods: 1108 subjects (899 aneurysm and 209 dissection patients) had <i>KIF6</i> 719Arg variant status determined. Results: The 719Arg variant in the <i>KIF6</i> gene correlated strongly with occurrence of AD. Specifically, <i>KIF6</i> 719Arg positivity (homozygous or heterozygous) was substantially more common in dissectors (69.8%) than non-dissectors (58.5%) (<i>p</i> = 0.003). Odds ratios (OR) for suffering aortic dissection ranged from 1.77 to 1.94 for Arg carriers in various dissection categories. These high OR associations were noted for both ascending and descending aneurysms and for homozygous and heterozygous Arg variant patients. The rate of aortic dissection over time was significantly higher for carriers of the Arg allele (<i>p</i> = 0.004). Additionally, Arg allele carriers were more likely to reach the combined endpoint of dissection or death (<i>p</i> = 0.03). Conclusions: We demonstrate the marked adverse impact of the 719Arg variant of the <i>KIF6</i> gene on the likelihood that a TAA patient will suffer aortic dissection. Clinical assessment of the variant status of this molecularly important gene may provide a valuable “non-size” criterion to enhance surgical decision making above and beyond the currently used metric of aortic size (diameter). |
| first_indexed | 2024-03-11T08:47:28Z |
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| institution | Directory Open Access Journal |
| issn | 2073-4425 |
| language | English |
| last_indexed | 2024-03-11T08:47:28Z |
| publishDate | 2023-01-01 |
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| spelling | doaj.art-0058b2465ec141b5b5765d638ad5471d2023-11-16T20:40:25ZengMDPI AGGenes2073-44252023-01-0114225210.3390/genes14020252<em>KIF6</em> Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic DissectionJuan J. Velasco0Yupeng Li1Bulat A. Ziganshin2Mohammad A. Zafar3John A. Rizzo4Deqiong Ma5Hui Zang6Asanish Kalyanasundaram7John A. Elefteriades8Aortic Institute, Yale University School of Medicine, New Haven, CT 06510, USADepartment of Statistics, Rowan University, Glassboro, NJ 08028, USAAortic Institute, Yale University School of Medicine, New Haven, CT 06510, USAAortic Institute, Yale University School of Medicine, New Haven, CT 06510, USADepartment of Statistics, Stony Brook University, Stony Brook, NY 11794, USADNA Diagnostics Laboratory, Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USADNA Diagnostics Laboratory, Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USAAortic Institute, Yale University School of Medicine, New Haven, CT 06510, USAAortic Institute, Yale University School of Medicine, New Haven, CT 06510, USABackground: KIF6 (kinesin family member 6), a protein coded by the <i>KIF6</i> gene, serves an important intracellular function to transport organelles along microtubules. In a pilot study, we found that a common <i>KIF6</i> Trp719Arg variant increased the propensity of thoracic aortic aneurysms (TAA) to suffer dissection (AD). The present study aims for a definite investigation of the predictive ability of <i>KIF6</i> 719Arg vis à vis AD. Confirmatory findings would enhance natural history prediction in TAA. Methods: 1108 subjects (899 aneurysm and 209 dissection patients) had <i>KIF6</i> 719Arg variant status determined. Results: The 719Arg variant in the <i>KIF6</i> gene correlated strongly with occurrence of AD. Specifically, <i>KIF6</i> 719Arg positivity (homozygous or heterozygous) was substantially more common in dissectors (69.8%) than non-dissectors (58.5%) (<i>p</i> = 0.003). Odds ratios (OR) for suffering aortic dissection ranged from 1.77 to 1.94 for Arg carriers in various dissection categories. These high OR associations were noted for both ascending and descending aneurysms and for homozygous and heterozygous Arg variant patients. The rate of aortic dissection over time was significantly higher for carriers of the Arg allele (<i>p</i> = 0.004). Additionally, Arg allele carriers were more likely to reach the combined endpoint of dissection or death (<i>p</i> = 0.03). Conclusions: We demonstrate the marked adverse impact of the 719Arg variant of the <i>KIF6</i> gene on the likelihood that a TAA patient will suffer aortic dissection. Clinical assessment of the variant status of this molecularly important gene may provide a valuable “non-size” criterion to enhance surgical decision making above and beyond the currently used metric of aortic size (diameter).https://www.mdpi.com/2073-4425/14/2/252aortic dissection<i>KIF6</i>kinesinaortic aneurysmascending aortarisk prediction |
| spellingShingle | Juan J. Velasco Yupeng Li Bulat A. Ziganshin Mohammad A. Zafar John A. Rizzo Deqiong Ma Hui Zang Asanish Kalyanasundaram John A. Elefteriades <em>KIF6</em> Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection Genes aortic dissection <i>KIF6</i> kinesin aortic aneurysm ascending aorta risk prediction |
| title | <em>KIF6</em> Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection |
| title_full | <em>KIF6</em> Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection |
| title_fullStr | <em>KIF6</em> Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection |
| title_full_unstemmed | <em>KIF6</em> Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection |
| title_short | <em>KIF6</em> Trp719Arg Genetic Variant Increases Risk for Thoracic Aortic Dissection |
| title_sort | em kif6 em trp719arg genetic variant increases risk for thoracic aortic dissection |
| topic | aortic dissection <i>KIF6</i> kinesin aortic aneurysm ascending aorta risk prediction |
| url | https://www.mdpi.com/2073-4425/14/2/252 |
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